SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		4 / 8 ASP A 373
ILE A 253
GLU A 249
GLY A 342
 None
 0.91A 1meiA-5ywwA:
undetectable		 1meiA-5ywwA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		3 / 3 GLU A 134
THR A 135
LEU A 161
 None
 0.61A 1v8bC-5ywwA:
undetectable		 1v8bC-5ywwA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		5 / 12 ILE A 252
ILE A 253
ALA A 254
LEU A 240
PHE A 264
 None
 1.20A 1xzxX-5ywwA:
undetectable		 1xzxX-5ywwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		3 / 3 GLY A 151
GLU A 134
ASN A 155
 None
 0.54A 1zq9A-5ywwA:
3.2		 1zq9A-5ywwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		4 / 4 LEU A 231
ILE A 376
ILE A 253
ALA A 265
 None
 0.84A 2i30A-5ywwA:
undetectable		 2i30A-5ywwA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		5 / 10 ILE A 378
VAL A 346
PHE A 264
THR A 374
ILE A 376
 None
 1.31A 3um5B-5ywwA:
undetectable		 3um5B-5ywwA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		5 / 12 VAL A  73
LEU A  35
VAL A  56
LEU A  59
VAL A  15
 None
 1.18A 3w68A-5ywwA:
undetectable		 3w68A-5ywwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		4 / 6 GLY A 217
TRP A 218
GLU A  50
ARG A 172
 None
 1.16A 4bqfA-5ywwA:
undetectable		 4bqfA-5ywwA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		5 / 12 SER A 168
VAL A 171
ARG A 172
ILE A 209
SER A 197
 None
 1.36A 4c49B-5ywwA:
undetectable		 4c49B-5ywwA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		5 / 12 SER A 168
VAL A 171
ARG A 172
ILE A 209
SER A 197
 None
 1.37A 4c49C-5ywwA:
undetectable		 4c49C-5ywwA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		5 / 12 SER A 168
VAL A 171
ARG A 172
ILE A 209
SER A 197
 None
 1.30A 4c49D-5ywwA:
undetectable		 4c49D-5ywwA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5yww NUCLEOTIDE BINDING
PROTEIN PINC
(Sulfolobus
islandicus) 		5 / 11 VAL A 279
ASP A 317
TYR A 272
GLY A 345
GLY A 342
 None
 1.01A 4xp4A-5ywwA:
undetectable		 4xp4A-5ywwA:
10.31