SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 TRP B 324
PHE B 284
SER B 299
VAL B 297
 None
 1.35A 3dqtA-5yx2B:
1.7
3dqtB-5yx2B:
undetectable		 3dqtA-5yx2B:
16.06
3dqtB-5yx2B:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		3 / 3 VAL B 307
VAL B 321
TRP B 335
 None
 0.90A 3l8lA-5yx2B:
undetectable
3l8lB-5yx2B:
undetectable		 3l8lA-5yx2B:
undetectable
3l8lB-5yx2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 SER B 299
VAL B 297
TRP B 324
PHE B 284
 None
 1.33A 3n5tA-5yx2B:
undetectable
3n5tB-5yx2B:
undetectable		 3n5tA-5yx2B:
16.06
3n5tB-5yx2B:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 TRP B 324
PHE B 284
SER B 299
VAL B 297
 None
 1.31A 3n61A-5yx2B:
undetectable
3n61B-5yx2B:
1.4		 3n61A-5yx2B:
11.03
3n61B-5yx2B:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 ALA B 320
GLU B 340
LEU B 343
LEU B 288
 None
 1.06A 4iomA-5yx2B:
undetectable		 4iomA-5yx2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 TRP B 324
PHE B 284
SER B 299
VAL B 297
 None
 1.33A 4k5jA-5yx2B:
undetectable
4k5jB-5yx2B:
undetectable		 4k5jA-5yx2B:
16.06
4k5jB-5yx2B:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 6 PHE B 368
MET B 283
ILE B 199
VAL B 321
 None
 1.30A 4mk4B-5yx2B:
undetectable		 4mk4B-5yx2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		5 / 12 LEU B 371
ASN B 326
ILE B 327
ALA B 244
ILE B 199
 None
 0.84A 4nkxC-5yx2B:
undetectable		 4nkxC-5yx2B:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		5 / 12 LEU B 371
ASN B 326
ILE B 327
ALA B 244
ILE B 199
 None
 0.82A 4nkxD-5yx2B:
undetectable		 4nkxD-5yx2B:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 TRP B 324
PHE B 284
SER B 299
VAL B 297
 None
 1.33A 5adlA-5yx2B:
undetectable
5adlB-5yx2B:
undetectable		 5adlA-5yx2B:
16.06
5adlB-5yx2B:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 TRP B 324
PHE B 284
SER B 299
VAL B 297
 None
 1.33A 5fj3A-5yx2B:
undetectable
5fj3B-5yx2B:
1.5		 5fj3A-5yx2B:
16.06
5fj3B-5yx2B:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 TRP B 324
PHE B 284
SER B 299
VAL B 297
 None
 1.33A 5vv7A-5yx2B:
1.4
5vv7B-5yx2B:
1.5		 5vv7A-5yx2B:
16.06
5vv7B-5yx2B:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 SER B 299
VAL B 297
TRP B 324
PHE B 284
 None
 1.34A 6av6A-5yx2B:
undetectable
6av6B-5yx2B:
undetectable		 6av6A-5yx2B:
21.59
6av6B-5yx2B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 TRP B 324
PHE B 284
SER B 299
VAL B 297
 None
 1.36A 6av6C-5yx2B:
undetectable
6av6D-5yx2B:
undetectable		 6av6C-5yx2B:
21.59
6av6D-5yx2B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens) 		4 / 7 SER B 299
VAL B 297
TRP B 324
PHE B 284
 None
 1.34A 6av7A-5yx2B:
undetectable
6av7B-5yx2B:
undetectable		 6av7A-5yx2B:
21.59
6av7B-5yx2B:
21.59