SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yx9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		5 / 12 ILE A 536
ALA A 539
ILE A 498
ASN A 460
LEU A 457
 None
 1.23A 1dlsA-5yx9A:
undetectable		 1dlsA-5yx9A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		3 / 3 GLU A 303
ALA A 305
SER A 322
 None
 0.67A 1errB-5yx9A:
undetectable		 1errB-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		4 / 7 VAL A 114
LEU A 151
LEU A 153
ALA A 179
 None
 0.82A 1j8uA-5yx9A:
undetectable		 1j8uA-5yx9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		5 / 12 LEU A 103
ALA A 136
LEU A 137
ARG A 160
TYR A 209
 None
 1.28A 1mx8A-5yx9A:
undetectable		 1mx8A-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		4 / 5 ILE A 345
ARG A 365
LEU A 332
PRO A 293
 None
 1.39A 1s8fA-5yx9A:
undetectable
1s8fB-5yx9A:
undetectable		 1s8fA-5yx9A:
undetectable
1s8fB-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		5 / 9 LEU A 332
LEU A 333
ILE A 345
PHE A 377
LEU A 298
 None
 1.20A 2f78A-5yx9A:
undetectable		 2f78A-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		5 / 9 LEU A 332
LEU A 333
ILE A 345
PHE A 377
LEU A 298
 None
 1.23A 2f78B-5yx9A:
undetectable		 2f78B-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		5 / 10 LEU A 454
GLY A 455
LEU A 456
LEU A 457
ILE A 498
 None
 0.92A 2f8dA-5yx9A:
undetectable		 2f8dA-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		5 / 10 LEU A 454
GLY A 455
LEU A 456
LEU A 457
ILE A 498
 None
 0.95A 2f8dB-5yx9A:
undetectable		 2f8dB-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		6 / 12 LEU A 298
ILE A 370
ALA A 369
VAL A 378
VAL A 329
LEU A 862
 None
 1.34A 2g78A-5yx9A:
undetectable		 2g78A-5yx9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		5 / 12 LEU A 192
PHE A 186
ALA A 243
GLY A 162
THR A 237
 None
 1.06A 3c6gA-5yx9A:
undetectable		 3c6gA-5yx9A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		4 / 8 GLU A 144
ASN A 143
HIS A 145
ILE A 887
 None
 1.17A 3kp6A-5yx9A:
2.8
3kp6B-5yx9A:
3.4		 3kp6A-5yx9A:
17.45
3kp6B-5yx9A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		4 / 5 ILE A 682
MET A 652
ASN A 654
PHE A 679
 None
 1.36A 3octA-5yx9A:
2.0		 3octA-5yx9A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		4 / 5 TYR A 656
THR A 669
PHE A 653
LEU A 678
 None
 0.94A 3qelC-5yx9A:
undetectable		 3qelC-5yx9A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		3 / 3 LYS A 874
SER A 282
GLN A 230
 None
 1.36A 3si7A-5yx9A:
undetectable		 3si7A-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_B_ACRB1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6
(Homo
sapiens) 		5 / 9 THR A 714
TYR A 711
GLY A 651
TYR A 656
PHE A 668
 None
 1.39A 5lrbB-5yx9A:
0.0		 5lrbB-5yx9A:
6.45