SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		4 / 5 GLY A  78
ILE A  76
VAL A  91
SER A  75
 None
 1.24A 1rs7A-5yxaA:
undetectable		 1rs7A-5yxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		4 / 8 SER A 155
VAL A 100
LEU A 102
PRO A  96
 None
 1.03A 2ddwA-5yxaA:
undetectable		 2ddwA-5yxaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		3 / 3 THR A  60
PRO A  56
THR A  58
 None
 0.87A 316dC-5yxaA:
undetectable		 316dC-5yxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		4 / 8 ILE A  42
PRO A  79
PHE A  29
LEU A  45
 None
 0.90A 4qopC-5yxaA:
undetectable		 4qopC-5yxaA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		4 / 7 GLY A 157
TYR A 160
SER A 129
HIS A 153
 None
 1.19A 4ws0A-5yxaA:
undetectable		 4ws0A-5yxaA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		5 / 11 SER A 151
HIS A 153
TYR A 160
TRP A 140
PRO A 138
 None
 1.14A 5albH-5yxaA:
undetectable		 5albH-5yxaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		4 / 5 SER A  33
ARG A  74
GLY A  77
GLU A  54
 None
 1.04A 5cdqA-5yxaA:
undetectable
5cdqB-5yxaA:
undetectable
5cdqC-5yxaA:
undetectable		 5cdqA-5yxaA:
10.45
5cdqB-5yxaA:
14.51
5cdqC-5yxaA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		4 / 5 SER A  33
ARG A  74
GLY A  77
GLU A  54
 None
 1.03A 5cdqR-5yxaA:
undetectable
5cdqS-5yxaA:
undetectable
5cdqT-5yxaA:
undetectable		 5cdqR-5yxaA:
10.45
5cdqS-5yxaA:
14.51
5cdqT-5yxaA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5yxa NON-STRUCTURAL
PROTEIN 1
(Yellow
fever
virus) 		5 / 12 ILE A  42
LEU A  48
THR A  47
LEU A  45
PHE A  29
 None
 1.10A 5xxiA-5yxaA:
undetectable		 5xxiA-5yxaA:
12.53