SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 249
TYR A 321
GLY A 353
PRO A 354
MET A 329
 SME  A 244 ( 3.8A)
None
None
None
None
 1.30A 1fdsA-5yxgA:
undetectable		 1fdsA-5yxgA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.19A 1hrkA-5yxgA:
undetectable		 1hrkA-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 GLY A 336
GLU A 355
GLY A 353
VAL A 335
ASN A 287
 SME  A 244 ( 4.9A)
None
None
SME  A 244 ( 4.5A)
None
 1.22A 1n2xA-5yxgA:
undetectable		 1n2xA-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.20A 2po5A-5yxgA:
undetectable		 2po5A-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 11 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.26A 2po5B-5yxgA:
undetectable		 2po5B-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.19A 2po7A-5yxgA:
undetectable		 2po7A-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.17A 2po7B-5yxgA:
undetectable		 2po7B-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 11 LEU A 436
LEU A 431
ILE A 409
THR A 378
VAL A 397
 None
 1.21A 2qd3A-5yxgA:
undetectable		 2qd3A-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.23A 2qd4B-5yxgA:
undetectable		 2qd4B-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		3 / 3 LEU A 297
ASN A 236
ARG A 306
 None
 0.94A 2qhfA-5yxgA:
undetectable		 2qhfA-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		4 / 8 GLN A 333
TRP A 468
THR A 432
GLN A 405
 None
 1.41A 2vxaF-5yxgA:
1.7
2vxaG-5yxgA:
1.6
2vxaI-5yxgA:
1.6		 2vxaF-5yxgA:
24.72
2vxaG-5yxgA:
24.72
2vxaI-5yxgA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 10 ILE A 264
PHE A 292
SER A 277
ALA A 253
LEU A 254
 None
 1.22A 3lw5B-5yxgA:
undetectable		 3lw5B-5yxgA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 10 ILE A 409
ALA A 392
ILE A 475
LEU A 443
THR A 419
 None
 1.25A 3prsA-5yxgA:
undetectable		 3prsA-5yxgA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.31A 3w1wB-5yxgA:
undetectable		 3w1wB-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 274
ALA A 253
THR A 322
LEU A 265
 SME  A 275 ( 3.7A)
None
None
None
 0.96A 4ejgA-5yxgA:
undetectable		 4ejgA-5yxgA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		4 / 8 ILE A 433
ARG A 474
LEU A 381
PHE A 461
 None
 0.76A 4v04A-5yxgA:
undetectable		 4v04A-5yxgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 THR A 211
GLN A 213
THR A 318
VAL A 317
VAL A 259
 None
 1.33A 6bzoC-5yxgA:
undetectable		 6bzoC-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 PHE A 216
VAL A 317
VAL A 240
THR A 322
LEU A 210
 None
 1.13A 6djzC-5yxgA:
undetectable		 6djzC-5yxgA:
undetectable