SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 MET A 269
ASN A 307
GLN A 204
 None
 1.01A 1xoqB-5yy0A:
undetectable		 1xoqB-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 THR A 351
PRO A 354
TYR A 100
 None
 0.94A 2dxrA-5yy0A:
undetectable		 2dxrA-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 ARG A 355
GLY A 356
SER A 261
 None
 0.64A 2xctB-5yy0A:
undetectable		 2xctB-5yy0A:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		4 / 5 HIS A  72
PHE A  45
LEU A 358
PRO A 377
 None
 1.35A 4o8zA-5yy0A:
undetectable		 4o8zA-5yy0A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		5 / 9 ALA A  76
THR A  75
VAL A 364
GLY A 347
ALA A  80
 None
 1.07A 4qvnK-5yy0A:
undetectable
4qvnL-5yy0A:
undetectable		 4qvnK-5yy0A:
14.56
4qvnL-5yy0A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		5 / 9 ALA A  76
THR A  75
VAL A 364
GLY A 347
ALA A  80
 None
 1.07A 4qvnY-5yy0A:
undetectable
4qvnZ-5yy0A:
undetectable		 4qvnY-5yy0A:
14.56
4qvnZ-5yy0A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		4 / 5 PRO A 377
HIS A 111
LEU A 276
PHE A 304
 None
 1.40A 5igjA-5yy0A:
undetectable		 5igjA-5yy0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 LYS A 249
HIS A 262
HIS A 260
 None
 1.26A 5oexA-5yy0A:
undetectable		 5oexA-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 LYS A 249
HIS A 262
HIS A 260
 None
 1.20A 5oexB-5yy0A:
undetectable		 5oexB-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 LYS A 249
HIS A 262
HIS A 260
 None
 1.19A 5oexC-5yy0A:
undetectable		 5oexC-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		5 / 10 LEU A 189
ILE A 101
LEU A 283
ALA A 287
LEU A 312
 None
 1.24A 5y7pB-5yy0A:
undetectable		 5y7pB-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		5 / 10 LEU A 189
ILE A 101
LEU A 283
ALA A 287
LEU A 312
 None
 1.25A 5y7pD-5yy0A:
undetectable		 5y7pD-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		5 / 10 LEU A 189
ILE A 101
LEU A 283
ALA A 287
LEU A 312
 None
 1.25A 5y7pG-5yy0A:
undetectable		 5y7pG-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 PHE A 317
ARG A 275
ALA A  71
 None
 0.83A 6ecfB-5yy0A:
undetectable		 6ecfB-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT
(Thermococcus
kodakarensis) 		4 / 8 ASP A 416
HIS A  72
ASP A 103
GLU A 106
 None
 1.28A 6mn4C-5yy0A:
undetectable		 6mn4C-5yy0A:
undetectable