SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5yy3 -
(-) 		4 / 8 CYH A 466
LEU A 479
ALA A 569
LEU A 481
 None
 0.92A 1hwiB-5yy3A:
undetectable		 1hwiB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5yy3 -
(-) 		5 / 9 CYH A 466
LEU A 479
ALA A 569
LEU A 481
LEU A 414
 None
 0.98A 1hwiA-5yy3A:
undetectable		 1hwiA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5yy3 -
(-) 		4 / 8 CYH A 466
LEU A 479
ALA A 569
LEU A 481
 None
 0.90A 1hwiC-5yy3A:
undetectable		 1hwiC-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5yy3 -
(-) 		5 / 10 CYH A 221
LEU A 220
LEU A 490
ILE A 485
ILE A 633
 None
 1.40A 1i18A-5yy3A:
undetectable
1i18B-5yy3A:
undetectable		 1i18A-5yy3A:
undetectable
1i18B-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5yy3 -
(-) 		5 / 12 HIS A 346
ASP A 322
HIS A 180
LEU A 350
GLY A 351
 None
 1.15A 1xwfA-5yy3A:
undetectable		 1xwfA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5yy3 -
(-) 		5 / 12 HIS A 346
ASP A 322
HIS A 180
LEU A 350
GLY A 351
 None
 1.14A 1xwfB-5yy3A:
undetectable		 1xwfB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5yy3 -
(-) 		5 / 12 HIS A 346
ASP A 322
HIS A 180
LEU A 350
GLY A 351
 None
 1.16A 1xwfC-5yy3A:
undetectable		 1xwfC-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5yy3 -
(-) 		5 / 12 HIS A 346
ASP A 322
HIS A 180
LEU A 350
GLY A 351
 None
 1.15A 1xwfD-5yy3A:
undetectable		 1xwfD-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5yy3 -
(-) 		4 / 4 SER A 258
ASP A 380
ARG A 167
ASP A 168
 None
 1.42A 2bm9C-5yy3A:
undetectable		 2bm9C-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5yy3 -
(-) 		4 / 8 ILE A 288
TRP A 386
GLY A 318
GLY A 319
 None
 0.89A 2qx4A-5yy3A:
undetectable
2qx4B-5yy3A:
undetectable		 2qx4A-5yy3A:
undetectable
2qx4B-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 5yy3 -
(-) 		4 / 6 TYR A 586
HIS A 208
TRP A 179
HIS A 180
 None
 1.05A 2r6vA-5yy3A:
undetectable		 2r6vA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5yy3 -
(-) 		5 / 9 PHE A 383
ALA A 377
ALA A 354
GLY A 351
ILE A 372
 None
 1.29A 2v7bA-5yy3A:
undetectable		 2v7bA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5yy3 -
(-) 		5 / 9 PHE A 383
ALA A 377
ALA A 354
GLY A 351
ILE A 372
 None
 1.26A 2v7bB-5yy3A:
undetectable		 2v7bB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5yy3 -
(-) 		4 / 7 PHE A 137
GLY A 376
ASP A 174
ARG A 526
 None
 1.18A 3aruA-5yy3A:
2.8		 3aruA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5yy3 -
(-) 		5 / 12 LEU A 396
ALA A 398
LEU A 205
LEU A 314
HIS A 389
 None
 1.11A 3erdA-5yy3A:
undetectable		 3erdA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 5yy3 -
(-) 		4 / 5 ASP A 171
GLU A 533
GLY A 532
TYR A 170
 None
 1.36A 3w9tB-5yy3A:
undetectable		 3w9tB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 5yy3 -
(-) 		4 / 5 ASP A 171
GLU A 533
GLY A 532
TYR A 170
 None
 1.40A 3w9tD-5yy3A:
undetectable		 3w9tD-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 5yy3 -
(-) 		4 / 5 ASP A 171
GLU A 533
GLY A 532
TYR A 170
 None
 1.42A 3w9tE-5yy3A:
undetectable		 3w9tE-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 5yy3 -
(-) 		4 / 5 ASP A 171
GLU A 533
GLY A 532
TYR A 170
 None
 1.40A 3w9tG-5yy3A:
undetectable		 3w9tG-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 5yy3 -
(-) 		4 / 7 TYR A 586
HIS A 208
TRP A 179
HIS A 180
 None
 1.06A 3zodA-5yy3A:
undetectable		 3zodA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 5yy3 -
(-) 		5 / 7 HIS A 176
HIS A 180
HIS A 346
ASN A 347
ALA A 377
 None
 0.88A 4p6sA-5yy3A:
7.7		 4p6sA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 5yy3 -
(-) 		4 / 7 HIS A 176
HIS A 180
HIS A 346
ASN A 347
 None
 0.84A 4p6sB-5yy3A:
7.8		 4p6sB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5yy3 -
(-) 		3 / 3 ASP A  58
HIS A  59
LYS A  60
 None
 0.98A 4qzuD-5yy3A:
undetectable		 4qzuD-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5yy3 -
(-) 		4 / 7 ASN A 133
PRO A 129
PHE A  51
PHE A 375
 None
 1.48A 4v32B-5yy3A:
undetectable		 4v32B-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5yy3 -
(-) 		5 / 12 GLY A 394
LEU A 205
TYR A 233
GLY A 318
LEU A 396
 None
 1.18A 5hg0A-5yy3A:
undetectable		 5hg0A-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5yy3 -
(-) 		5 / 7 CYH A 152
ILE A 151
HIS A 158
LEU A 157
ALA A 161
 None
 1.37A 5hrqE-5yy3A:
undetectable
5hrqF-5yy3A:
undetectable
5hrqJ-5yy3A:
undetectable		 5hrqE-5yy3A:
undetectable
5hrqF-5yy3A:
undetectable
5hrqJ-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 5yy3 -
(-) 		5 / 7 HIS A 176
HIS A 180
HIS A 346
ASN A 347
ALA A 377
 None
 0.86A 5i3aA-5yy3A:
7.6		 5i3aA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 5yy3 -
(-) 		5 / 7 HIS A 176
HIS A 180
HIS A 346
ASN A 347
ALA A 377
 None
 0.86A 5i3aB-5yy3A:
7.7		 5i3aB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 5yy3 -
(-) 		5 / 7 HIS A 176
HIS A 180
HIS A 346
ASN A 347
ALA A 377
 None
 0.89A 5i3bA-5yy3A:
7.6		 5i3bA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5yy3 -
(-) 		5 / 12 GLY A 319
ASN A 347
GLN A 324
LEU A 390
HIS A 208
 None
 1.16A 5kocB-5yy3A:
undetectable		 5kocB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5yy3 -
(-) 		3 / 3 HIS A 545
HIS A 585
HIS A 584
 None
 0.87A 5oexA-5yy3A:
undetectable		 5oexA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5yy3 -
(-) 		5 / 12 LEU A 417
LEU A 483
TRP A 459
ALA A 503
LEU A 479
 None
 1.17A 5og9B-5yy3A:
undetectable		 5og9B-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 5yy3 -
(-) 		4 / 7 GLN A 324
ASP A 322
HIS A 208
TYR A 178
 None
 1.04A 5ov9B-5yy3A:
undetectable		 5ov9B-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5yy3 -
(-) 		4 / 6 ARG A 214
ALA A 525
TYR A 457
SER A 522
 None
 1.13A 5phhA-5yy3A:
undetectable		 5phhA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5yy3 -
(-) 		4 / 6 ARG A 517
PHE A 484
ILE A 626
THR A 627
 None
 0.91A 5vceA-5yy3A:
undetectable		 5vceA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5yy3 -
(-) 		5 / 12 PHE A 563
ILE A 633
GLY A 432
PHE A 631
ASP A 489
 None
 1.14A 5x66A-5yy3A:
undetectable
5x66B-5yy3A:
undetectable		 5x66A-5yy3A:
undetectable
5x66B-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5yy3 -
(-) 		5 / 12 TYR A 183
GLY A 319
LEU A 337
ASN A 329
ASP A 322
 None
 1.07A 5yn6A-5yy3A:
undetectable		 5yn6A-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5yy3 -
(-) 		5 / 12 TYR A 183
GLY A 319
LEU A 337
ASN A 329
ASP A 322
 None
 1.06A 5yniA-5yy3A:
undetectable		 5yniA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5yy3 -
(-) 		5 / 12 TYR A 183
GLY A 319
LEU A 337
ASN A 329
ASP A 322
 None
 1.05A 5ynmA-5yy3A:
undetectable		 5ynmA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5yy3 -
(-) 		4 / 5 ILE A 626
PHE A 566
ARG A 590
THR A 480
 None
 1.27A 5z84N-5yy3A:
undetectable
5z84W-5yy3A:
undetectable		 5z84N-5yy3A:
undetectable
5z84W-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5yy3 -
(-) 		4 / 5 GLY A 591
ASN A 597
ARG A 590
ARG A 598
 None
 1.38A 6dwdB-5yy3A:
undetectable
6dwdD-5yy3A:
undetectable		 6dwdB-5yy3A:
undetectable
6dwdD-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5yy3 -
(-) 		4 / 8 TRP A 179
HIS A 208
ARG A 214
GLU A 499
 None
 1.26A 6mn4C-5yy3A:
undetectable		 6mn4C-5yy3A:
undetectable