SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5yy5

(;
) 		5 / 12 GLY D 104
GLY D 103
GLY D 102
LEU C  45
SER D   7
 None
 1.20A 1xdsA-5yy5D:
undetectable		 1xdsA-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5yy5

(;
) 		5 / 12 GLY D 104
GLY D 103
GLY D 102
LEU C  45
SER D   7
 None
 1.16A 1xdsB-5yy5D:
undetectable		 1xdsB-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5yy5

(;
) 		4 / 7 TYR C  91
TYR D  37
PRO D  45
TYR D  88
 None
 0.60A 2oldA-5yy5C:
13.2
2oldB-5yy5C:
13.3		 2oldA-5yy5C:
undetectable
2oldB-5yy5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5yy5

(;
) 		4 / 7 TYR D  37
PRO D  45
TYR D  88
TYR C  91
 None
 0.54A 2oldA-5yy5D:
19.3
2oldB-5yy5D:
19.4		 2oldA-5yy5D:
undetectable
2oldB-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5yy5 -
(-) 		4 / 6 ILE C  78
PHE C  27
ALA C  24
ASN C  94
 None
 1.08A 3pgyA-5yy5C:
undetectable
3pgyB-5yy5C:
undetectable		 3pgyA-5yy5C:
undetectable
3pgyB-5yy5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5yy5 -
(-) 		6 / 12 VAL C   2
ALA C  24
MET C  34
ARG C  71
ASN C  73
TYR C  97
 None
 0.92A 3qxvA-5yy5C:
19.4		 3qxvA-5yy5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5yy5 -
(-) 		5 / 12 VAL C   2
ALA C  24
MET C  34
ARG C  71
TYR C  97
 None
 0.89A 3qxvB-5yy5C:
19.3		 3qxvB-5yy5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5yy5 -
(-) 		5 / 11 VAL C   2
ALA C  24
MET C  34
ARG C  71
ASN C  73
 None
 0.69A 3qxvC-5yy5C:
19.6		 3qxvC-5yy5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5yy5

(;
) 		5 / 12 ILE D  49
GLN D   6
TYR D  87
GLN C  39
LEU C  45
 None
 1.44A 4qztA-5yy5D:
undetectable		 4qztA-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 5yy5 -
(-) 		4 / 7 TYR D  33
TYR D  37
TYR D  50
PRO D  56
 None
 0.65A 5aclA-5yy5D:
19.2		 5aclA-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 5yy5 -
(-) 		4 / 7 TYR D  35
TYR D  37
GLN D  54
ASP D  53
 None
 1.42A 5ov9B-5yy5D:
undetectable		 5ov9B-5yy5D:
undetectable