SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yy8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		4 / 5 SER A  45
ARG A  44
LEU A 306
ASN A 307
 None
 1.17A 1y0xX-5yy8A:
undetectable		 1y0xX-5yy8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 240
LEU A 227
ILE A 186
LEU A 184
 None
 0.94A 2byoA-5yy8A:
undetectable		 2byoA-5yy8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		4 / 7 ILE A  57
LEU A  56
VAL A 297
GLY A 286
 None
 0.81A 2wd9A-5yy8A:
undetectable		 2wd9A-5yy8A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		3 / 3 VAL A 233
ASN A 277
TRP A 319
 None
 1.06A 2y00B-5yy8A:
undetectable		 2y00B-5yy8A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		3 / 3 GLU A 221
GLU A 195
ASN A 148
 None
 0.89A 3lp9B-5yy8A:
5.9
3lp9D-5yy8A:
4.8		 3lp9B-5yy8A:
17.86
3lp9D-5yy8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 237
GLY A 286
ASN A 141
CYH A 211
PHE A 253
 None
 1.42A 3r24A-5yy8A:
undetectable		 3r24A-5yy8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 156
ASN A 167
ASP A 169
ILE A 153
VAL A 144
 None
 1.19A 4dx5B-5yy8A:
undetectable		 4dx5B-5yy8A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		5 / 9 ASP A 115
PRO A  90
GLY A 108
SER A 113
GLY A 111
 None
 1.34A 4mmbA-5yy8A:
undetectable		 4mmbA-5yy8A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 151
ASP A 114
LEU A 116
PRO A 131
ILE A 130
 None
 1.49A 5dlvB-5yy8A:
undetectable		 5dlvB-5yy8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  47
ALA A  58
LEU A  56
ILE A 287
ALA A 285
 None
 1.25A 5eypB-5yy8A:
undetectable		 5eypB-5yy8A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 294
ALA A 288
THR A  49
ALA A 285
GLY A 237
 None
 1.11A 5veuA-5yy8A:
undetectable		 5veuA-5yy8A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 ARG A 236
GLY A 255
MET A 231
GLY A 251
SER A 283
 None
 1.19A 5vooE-5yy8A:
undetectable		 5vooE-5yy8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 TRP A 178
ARG A 136
THR A 137
ILE A 153
 None
 1.08A 6a4iA-5yy8A:
undetectable		 6a4iA-5yy8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 GLY A  61
LEU A  47
ALA A  58
GLU A  72
 None
 0.80A 6mdqA-5yy8A:
undetectable		 6mdqA-5yy8A:
19.28