SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5yyl -
(-) 		4 / 7 TYR A 115
THR A  79
ASN A  64
TYR A  42
 None
 1.26A 1afsA-5yylA:
undetectable		 1afsA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5yyl -
(-) 		4 / 7 TYR A 115
THR A  79
ASN A  64
TYR A  42
 None
 1.26A 1afsB-5yylA:
undetectable		 1afsB-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5yyl -
(-) 		4 / 5 SER A 186
GLU A 211
TYR A 233
SER A 228
 None
 1.43A 1vidA-5yylA:
undetectable		 1vidA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5yyl -
(-) 		5 / 12 LEU A 317
GLY A 255
TYR A 266
ASP A  68
ALA A 308
 None
 1.08A 2bm9A-5yylA:
undetectable		 2bm9A-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5yyl -
(-) 		5 / 11 GLY A 297
ILE A 301
SER A 274
PRO A 269
SER A 268
 None
 1.32A 3bjwH-5yylA:
undetectable		 3bjwH-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 5yyl -
(-) 		5 / 12 SER A 429
PHE A 318
VAL A 344
LEU A  31
HIS A 431
 None
 1.42A 3lxeA-5yylA:
undetectable		 3lxeA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 5yyl -
(-) 		5 / 12 SER A 429
PHE A 318
VAL A 344
LEU A  31
HIS A 431
 None
 1.43A 3lxeB-5yylA:
undetectable		 3lxeB-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5yyl -
(-) 		4 / 8 ASP A 207
SER A 140
SER A 125
ASP A 251
 None
 1.16A 4kttA-5yylA:
undetectable		 4kttA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5yyl -
(-) 		4 / 8 ASP A 207
SER A 140
SER A 125
ASP A 251
 None
 1.16A 4kttC-5yylA:
undetectable		 4kttC-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5yyl -
(-) 		5 / 11 VAL A  86
ILE A 121
TYR A 115
LEU A 127
SER A 123
 None
 1.19A 4m83A-5yylA:
undetectable		 4m83A-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5yyl -
(-) 		4 / 8 ASP A 207
SER A 140
SER A 125
ASP A 251
 None
 1.18A 4ndnA-5yylA:
undetectable		 4ndnA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5yyl -
(-) 		5 / 12 TYR A 276
LEU A 213
GLY A 212
SER A 306
ASP A 232
 None
 1.29A 6bxlA-5yylA:
undetectable		 6bxlA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5yyl -
(-) 		5 / 10 SER A  67
LEU A 154
LEU A 127
ASP A  70
ILE A 205
 None
 1.50A 6dm2B-5yylA:
undetectable
6dm2C-5yylA:
undetectable		 6dm2B-5yylA:
undetectable
6dm2C-5yylA:
undetectable