SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 12 ALA A2101
TYR A2102
ASP A2118
GLN A2114
GLU A2105
 None
 1.15A 1dy4A-5yz0A:
undetectable		 1dy4A-5yz0A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 8 MET A2540
THR A2539
ALA A2535
LEU A2531
VAL A2463
 None
 1.41A 1sn5C-5yz0A:
undetectable		 1sn5C-5yz0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 4 LEU A2314
SER A2313
TYR A2322
LEU A2262
 None
 1.20A 1xz1A-5yz0A:
undetectable		 1xz1A-5yz0A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 4 LEU A2314
SER A2313
TYR A2322
LEU A2262
 None
 1.21A 1xz3A-5yz0A:
undetectable		 1xz3A-5yz0A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		3 / 3 LYS A2311
ASP A2484
ASN A2381
 None
 0.93A 2bm9A-5yz0A:
undetectable		 2bm9A-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		3 / 3 LYS A2329
ASP A2475
ASN A2496
 None
 1.08A 2bm9A-5yz0A:
undetectable		 2bm9A-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		3 / 3 LYS A2100
ASP A2560
ASP A2331
 None
 1.12A 2br4A-5yz0A:
undetectable		 2br4A-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 6 LEU A2471
ARG A2544
MET A2543
LEU A2550
 None
 1.05A 2dysN-5yz0A:
undetectable
2dysW-5yz0A:
undetectable		 2dysN-5yz0A:
undetectable
2dysW-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 GLU A1776
PRO A1914
ARG A1913
GLY A1805
 None
 1.14A 2hs1B-5yz0A:
undetectable		 2hs1B-5yz0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 11 GLY A2316
ILE A2260
ALA A2215
THR A2180
ILE A2376
 None
 1.12A 2nnhA-5yz0A:
undetectable		 2nnhA-5yz0A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 LEU A2262
PHE A2321
ILE A2293
PHE A2296
 None
 0.94A 2opxA-5yz0A:
undetectable		 2opxA-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		3 / 3 LEU A1901
ASN A1946
ARG A1905
 None
 0.93A 2qhfA-5yz0A:
undetectable		 2qhfA-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 PHE A2532
PRO A2512
ALA A2627
LEU A2623
 None
 1.09A 2vcvA-5yz0A:
2.6		 2vcvA-5yz0A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 12 ASP A2330
LEU A2332
ASN A2480
ASP A2494
ASP A2335
 None
 1.44A 2x2iA-5yz0A:
undetectable		 2x2iA-5yz0A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 12 ASP A2330
LEU A2332
ASN A2480
ASP A2494
ASP A2335
 None
 1.47A 2x2iB-5yz0A:
undetectable		 2x2iB-5yz0A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		3 / 3 MET A1656
MET A2526
PHE A2440
 None
 1.28A 3gn8A-5yz0A:
undetectable		 3gn8A-5yz0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 12 THR A2364
LEU A2338
ILE A2470
MET A2543
LEU A2349
 None
 1.31A 3gwxA-5yz0A:
undetectable		 3gwxA-5yz0A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 8 ASP A2475
GLY A2478
TYR A2643
GLU A2509
ARG A2407
 None
 1.47A 3s3mA-5yz0A:
undetectable		 3s3mA-5yz0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 ASP A2372
ASP A2331
PRO A2369
ARG A2337
 None
 1.21A 3s3oA-5yz0A:
undetectable		 3s3oA-5yz0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 ASP A2475
TYR A2643
GLU A2509
ARG A2407
 None
 1.13A 3s3oA-5yz0A:
undetectable		 3s3oA-5yz0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 ASN A1946
ALA A1943
ARG A1904
ALA A1934
 None
 1.13A 3twpA-5yz0A:
undetectable		 3twpA-5yz0A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 ASP A2330
ASP A2335
ASP A2475
ASP A2494
 None
 1.18A 4feuB-5yz0A:
4.9		 4feuB-5yz0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 8 ASP A2330
ASP A2335
ASP A2475
ASP A2494
 None
 1.21A 4feuF-5yz0A:
5.1		 4feuF-5yz0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 ASP A2330
ASP A2335
ASP A2475
ASP A2494
 None
 1.21A 4fewB-5yz0A:
3.6		 4fewB-5yz0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		3 / 3 LEU A1910
MET A1856
ASP A1815
 None
 0.77A 4j7xB-5yz0A:
undetectable		 4j7xB-5yz0A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 6 ILE A1552
ILE A1532
PHE A1632
LEU A1588
 None
 0.83A 4m51A-5yz0A:
undetectable		 4m51A-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 4 ASP A2335
GLY A2375
PRO A2369
GLN A2263
 None
 1.27A 4oltA-5yz0A:
0.5		 4oltA-5yz0A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 5 LEU A2145
GLU A2340
LEU A2093
HIS A2151
 None
 1.15A 4xi3B-5yz0A:
undetectable		 4xi3B-5yz0A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 6 SER A1711
ARG A2533
GLY A2530
GLU A2529
 None
 1.00A 5btaA-5yz0A:
undetectable
5btaB-5yz0A:
undetectable
5btaC-5yz0A:
undetectable		 5btaA-5yz0A:
11.76
5btaB-5yz0A:
16.06
5btaC-5yz0A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 6 SER A1711
ARG A2533
GLY A2530
GLU A2529
 None
 0.97A 5btcA-5yz0A:
undetectable
5btcC-5yz0A:
undetectable
5btcD-5yz0A:
undetectable		 5btcA-5yz0A:
11.76
5btcC-5yz0A:
11.76
5btcD-5yz0A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 6 SER A1711
ARG A2533
GLY A2530
GLU A2529
 None
 1.00A 5btcA-5yz0A:
undetectable
5btcB-5yz0A:
undetectable
5btcC-5yz0A:
undetectable		 5btcA-5yz0A:
11.76
5btcB-5yz0A:
16.06
5btcC-5yz0A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 5 ARG A2008
GLY A2007
THR A1989
GLU A1986
 None
 1.11A 5btiA-5yz0A:
undetectable
5btiB-5yz0A:
undetectable		 5btiA-5yz0A:
11.76
5btiB-5yz0A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 5 ARG A2008
GLY A2007
THR A1989
GLU A1986
 None
 1.07A 5btiC-5yz0A:
undetectable
5btiD-5yz0A:
undetectable		 5btiC-5yz0A:
11.76
5btiD-5yz0A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 12 ALA A2043
GLY A2079
THR A2276
SER A2075
TYR A2078
 None
 1.36A 5hfjA-5yz0A:
undetectable		 5hfjA-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 12 ALA A2043
GLY A2079
THR A2276
SER A2075
TYR A2078
 None
 1.40A 5hfjC-5yz0A:
undetectable		 5hfjC-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		5 / 12 ALA A2043
GLY A2079
THR A2276
SER A2075
TYR A2078
 None
 1.28A 5hfjG-5yz0A:
undetectable		 5hfjG-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 5 ASP A1586
THR A1589
GLN A1590
ARG A1593
 None
 1.18A 5k9dA-5yz0A:
undetectable		 5k9dA-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		3 / 3 LEU A1907
LEU A1910
TRP A1779
 None
 0.86A 5nwuA-5yz0A:
undetectable		 5nwuA-5yz0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 8 ASN A1668
THR A2528
ILE A1662
GLY A2524
 None
 1.00A 5nzxA-5yz0A:
undetectable		 5nzxA-5yz0A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_A_K1SA304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 5 GLU A1776
TRP A1779
VAL A1802
LEU A1809
 None
 1.44A 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
0.4		 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 5 TRP A1779
VAL A1775
LEU A1809
GLU A1776
 None
 1.49A 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
0.4		 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 5 TRP A1779
VAL A1802
LEU A1809
GLU A1776
 None
 1.43A 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
0.4		 5qjqA-5yz0A:
undetectable
5qjqB-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 5 PHE A2138
PHE A2142
LEU A2145
LEU A2169
 None
 1.28A 5veuH-5yz0A:
undetectable		 5veuH-5yz0A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 6 GLY A2098
TYR A2097
ARG A2148
VAL A2156
 None
 0.74A 5x80A-5yz0A:
undetectable
5x80B-5yz0A:
undetectable		 5x80A-5yz0A:
20.00
5x80B-5yz0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 7 ARG A2148
VAL A2156
GLY A2098
TYR A2097
 None
 0.68A 5x80C-5yz0A:
undetectable
5x80D-5yz0A:
undetectable		 5x80C-5yz0A:
20.00
5x80D-5yz0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens) 		4 / 8 LEU A2471
ARG A2544
MET A2543
LEU A2550
 None
 0.87A 5zcoA-5yz0A:
4.0
5zcoJ-5yz0A:
undetectable		 5zcoA-5yz0A:
undetectable
5zcoJ-5yz0A:
undetectable