SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TPX_C_ACTC207_0 (E3 UBIQUITIN-PROTEIN LIGASE MDM2)	5z02	E3 UBIQUITIN-PROTEIN LIGASE MDM2 (Homo sapiens)	4 / 4	LYS A 10 PRO A 11 LEU A 12 ASN A 85	None	1.03A	3tpxC-5z02A: 16.5	3tpxC-5z02A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GS4_A_ESTA603_2 (ESTROGEN RECEPTOR)	5z02	E3 UBIQUITIN-PROTEIN LIGASE MDM2 (Homo sapiens)	4 / 6	LEU A 86 LEU A 17 LEU A 14 LEU A 64	None	0.96A	5gs4A-5z02A: undetectable	5gs4A-5z02A: 15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_B_TA1B501_2 (TUBULIN BETA CHAIN)	5z02	E3 UBIQUITIN-PROTEIN LIGASE MDM2 (Homo sapiens)	4 / 5	LEU A 33 THR A 80 PRO A 9 ARG A 8	NUT A 101 (-4.1A) None None None	1.40A	6ew0B-5z02A: undetectable	6ew0B-5z02A: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_D_TA1D501_2 (TUBULIN BETA CHAIN)	5z02	E3 UBIQUITIN-PROTEIN LIGASE MDM2 (Homo sapiens)	4 / 5	LEU A 33 THR A 80 PRO A 9 ARG A 8	NUT A 101 (-4.1A) None None None	1.40A	6ew0D-5z02A: undetectable	6ew0D-5z02A: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_H_TA1H501_2 (TUBULIN BETA CHAIN)	5z02	E3 UBIQUITIN-PROTEIN LIGASE MDM2 (Homo sapiens)	4 / 5	LEU A 33 THR A 80 PRO A 9 ARG A 8	NUT A 101 (-4.1A) None None None	1.40A	6ew0H-5z02A: undetectable	6ew0H-5z02A: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_I_TA1I501_2 (TUBULIN BETA CHAIN)	5z02	E3 UBIQUITIN-PROTEIN LIGASE MDM2 (Homo sapiens)	4 / 5	LEU A 33 THR A 80 PRO A 9 ARG A 8	NUT A 101 (-4.1A) None None None	1.40A	6ew0I-5z02A: undetectable	6ew0I-5z02A: 16.87

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3TPX_C_ACTC207_0","E3 UBIQUITIN-PROTEIN LIGASE MDM2","5z02","E3 UBIQUITIN-PROTEIN LIGASE MDM2","Homo sapiens",4,"LYS A  10;PRO A  11;LEU A  12;ASN A  85","None","1.03A","3tpxC-5z02A:16.5","3tpxC-5z02A:undetectable"],["5GS4_A_ESTA603_2","ESTROGEN RECEPTOR","5z02","E3 UBIQUITIN-PROTEIN LIGASE MDM2","Homo sapiens",4,"LEU A  86;LEU A  17;LEU A  14;LEU A  64","None","0.96A","5gs4A-5z02A:undetectable","5gs4A-5z02A:15.68"],["6EW0_B_TA1B501_2","TUBULIN BETA CHAIN","5z02","E3 UBIQUITIN-PROTEIN LIGASE MDM2","Homo sapiens",4,"LEU A  33;THR A  80;PRO A   9;ARG A   8","NUT A 101 (-4.1A);None;None;None","1.40A","6ew0B-5z02A:undetectable","6ew0B-5z02A:16.87"],["6EW0_D_TA1D501_2","TUBULIN BETA CHAIN","5z02","E3 UBIQUITIN-PROTEIN LIGASE MDM2","Homo sapiens",4,"LEU A  33;THR A  80;PRO A   9;ARG A   8","NUT A 101 (-4.1A);None;None;None","1.40A","6ew0D-5z02A:undetectable","6ew0D-5z02A:16.87"],["6EW0_H_TA1H501_2","TUBULIN BETA CHAIN","5z02","E3 UBIQUITIN-PROTEIN LIGASE MDM2","Homo sapiens",4,"LEU A  33;THR A  80;PRO A   9;ARG A   8","NUT A 101 (-4.1A);None;None;None","1.40A","6ew0H-5z02A:undetectable","6ew0H-5z02A:16.87"],["6EW0_I_TA1I501_2","TUBULIN BETA CHAIN","5z02","E3 UBIQUITIN-PROTEIN LIGASE MDM2","Homo sapiens",4,"LEU A  33;THR A  80;PRO A   9;ARG A   8","NUT A 101 (-4.1A);None;None;None","1.40A","6ew0I-5z02A:undetectable","6ew0I-5z02A:16.87"]]