SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		4 / 8 SER A 182
SER A  10
ALA A  79
ILE A 111
 None
 1.11A 1gm7A-5z03A:
undetectable
1gm7B-5z03A:
undetectable		 1gm7A-5z03A:
undetectable
1gm7B-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		4 / 6 ILE A 228
ARG A 255
LEU A 258
LEU A 230
 None
 0.95A 2rlfA-5z03A:
undetectable
2rlfD-5z03A:
undetectable		 2rlfA-5z03A:
20.00
2rlfD-5z03A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 12 LEU A  54
LEU A  57
ASN A  58
LEU A  60
LEU A  83
 None
 1.22A 3d90A-5z03A:
undetectable		 3d90A-5z03A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 12 ASN A 176
GLY A 175
LEU A 213
MET A 179
ILE A 181
 None
 1.37A 3h52A-5z03A:
undetectable		 3h52A-5z03A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 12 PHE A 268
GLY A 231
ALA A 106
GLY A 104
ASN A 176
 None
 1.20A 3jzjA-5z03A:
undetectable		 3jzjA-5z03A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 9 LEU A  71
PRO A 127
THR A 276
HIS A  31
LEU A 150
 None
 1.29A 3q1eB-5z03A:
undetectable
3q1eD-5z03A:
undetectable		 3q1eB-5z03A:
20.54
3q1eD-5z03A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		3 / 3 PHE A 146
GLN A 272
PHE A   4
 None
 0.84A 3rv5A-5z03A:
undetectable		 3rv5A-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 9 PHE A 108
THR A  68
VAL A  70
LEU A  57
ILE A   7
 None
 1.20A 3tbgD-5z03A:
undetectable		 3tbgD-5z03A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 12 LEU A 172
ILE A 260
ILE A 228
VAL A 198
LEU A 199
 None
 1.04A 3w67B-5z03A:
undetectable		 3w67B-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		4 / 5 TRP A 147
GLY A  30
ALA A  29
PHE A 133
 None
 1.39A 3wqwA-5z03A:
undetectable		 3wqwA-5z03A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 12 LEU A  91
LEU A 115
LEU A 116
ALA A 117
LEU A  83
 None
 1.09A 4ltwA-5z03A:
undetectable		 4ltwA-5z03A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 10 LEU A  57
ASP A  56
LEU A  63
LEU A 100
ILE A 102
 None
 0.95A 4odoA-5z03A:
undetectable		 4odoA-5z03A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 10 LEU A  57
ASP A  56
LEU A  63
LEU A 100
ILE A 102
 None
 0.97A 4odoB-5z03A:
undetectable		 4odoB-5z03A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 10 LEU A  57
ASP A  56
LEU A  63
LEU A 100
ILE A 102
 None
 0.95A 4odoC-5z03A:
undetectable		 4odoC-5z03A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 11 LEU A  57
ASP A  56
LEU A  63
LEU A 100
ILE A 102
 None
 1.03A 4odrA-5z03A:
undetectable
4odrB-5z03A:
undetectable		 4odrA-5z03A:
21.43
4odrB-5z03A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		4 / 8 PHE A 141
GLY A 269
ASN A 132
ILE A 202
 None
 0.85A 4qoiA-5z03A:
undetectable
4qoiB-5z03A:
undetectable		 4qoiA-5z03A:
15.56
4qoiB-5z03A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 9 ILE A  39
ASN A  35
LEU A   3
LEU A  71
ILE A  69
 None
 1.22A 4r38C-5z03A:
undetectable		 4r38C-5z03A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		4 / 7 MET A 212
HIS A 270
GLY A 175
ASN A 176
 None
 1.26A 5a5zC-5z03A:
undetectable		 5a5zC-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 12 ILE A 221
GLY A 220
LEU A 199
LEU A 230
LEU A 213
 None
 1.11A 5nfjB-5z03A:
2.5		 5nfjB-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 12 ILE A 221
GLY A 220
LEU A 199
LEU A 230
LEU A 213
 None
 1.13A 5nfjC-5z03A:
2.4		 5nfjC-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		4 / 8 THR A 276
HIS A 105
ASN A 132
PHE A 133
 None
 1.06A 5v4vA-5z03A:
undetectable		 5v4vA-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		4 / 8 THR A 276
HIS A 105
ASN A 132
PHE A 133
 None
 1.06A 5v4vB-5z03A:
undetectable		 5v4vB-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 10 PRO A 223
ALA A 227
GLY A 170
THR A 171
ILE A 196
 None
 1.32A 5vyhA-5z03A:
undetectable		 5vyhA-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE
(Escherichia
coli) 		5 / 12 ILE A 196
LEU A 222
GLY A 174
ILE A 157
LEU A 266
 None
 1.15A 6dwnC-5z03A:
undetectable		 6dwnC-5z03A:
21.59