SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 9 PHE A 358
LEU A  70
ILE A  75
ASP A 141
ILE A 354
 None
 1.36A 1gebA-5z0cA:
undetectable		 1gebA-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 GLY A 279
VAL A 190
GLY A 194
GLY A 195
ILE A 253
 None
None
BME  A 405 ( 4.2A)
BME  A 405 (-3.3A)
None
 0.83A 1hxbA-5z0cA:
undetectable		 1hxbA-5z0cA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 9 ILE A 329
ILE A 354
ASP A 353
GLY A  49
THR A 357
 GOL  A 403 (-4.4A)
None
None
None
None
 1.39A 2dtjA-5z0cA:
undetectable
2dtjB-5z0cA:
undetectable		 2dtjA-5z0cA:
undetectable
2dtjB-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 LEU A 196
SER A  53
CYH A  51
HIS A 260
LEU A 265
 BME  A 405 (-3.9A)
ZN  A 402 ( 3.9A)
ZN  A 402 (-2.3A)
None
None
 1.07A 2hc4A-5z0cA:
undetectable		 2hc4A-5z0cA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 VAL A 278
SER A  53
CYH A  51
HIS A 260
LEU A 265
 None
ZN  A 402 ( 3.9A)
ZN  A 402 (-2.3A)
None
None
 1.26A 2hc4A-5z0cA:
undetectable		 2hc4A-5z0cA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 LEU A 196
SER A  53
CYH A  51
HIS A 260
LEU A 265
 BME  A 405 (-3.9A)
ZN  A 402 ( 3.9A)
ZN  A 402 (-2.3A)
None
None
 1.14A 2zlcA-5z0cA:
undetectable		 2zlcA-5z0cA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 VAL A 278
SER A  53
CYH A  51
HIS A 260
LEU A 265
 None
ZN  A 402 ( 3.9A)
ZN  A 402 (-2.3A)
None
None
 1.28A 2zlcA-5z0cA:
undetectable		 2zlcA-5z0cA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 MET A 338
ALA A 337
TYR A 139
ASN A 335
ILE A  50
 None
 1.27A 3a65A-5z0cA:
undetectable		 3a65A-5z0cA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 LEU A 196
ILE A 252
ILE A 170
SER A 174
ALA A 168
 BME  A 405 (-3.9A)
None
None
None
None
 1.20A 3axtA-5z0cA:
6.2		 3axtA-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		4 / 6 LEU A 159
SER A 161
ILE A 153
PHE A 316
 None
 0.73A 3ko0B-5z0cA:
undetectable		 3ko0B-5z0cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		4 / 6 LEU A 159
SER A 161
ILE A 153
PHE A 316
 None
 0.70A 3ko0S-5z0cA:
undetectable		 3ko0S-5z0cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 GLY A 247
LYS A 270
VAL A 190
ASP A 250
LEU A 176
 None
 0.92A 3m6vB-5z0cA:
6.3		 3m6vB-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		4 / 7 VAL A 278
VAL A 276
LEU A 275
MET A 249
 None
 0.76A 4e1gB-5z0cA:
undetectable		 4e1gB-5z0cA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		4 / 6 GLY A 306
GLY A 305
GLU A 115
ILE A 100
 None
 0.89A 4fglD-5z0cA:
4.4		 4fglD-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		4 / 7 ALA A 324
SER A 161
VAL A 351
ARG A 349
 None
None
None
BME  A 405 (-3.0A)
 1.13A 4ijiH-5z0cA:
undetectable		 4ijiH-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 10 PHE A 358
LEU A  70
GLY A 137
ASP A 141
ILE A 354
 None
 1.16A 4jx1B-5z0cA:
undetectable		 4jx1B-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 LEU A 165
HIS A 148
ILE A 100
ARG A 177
TYR A 173
 None
 1.21A 5dlvA-5z0cA:
undetectable		 5dlvA-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 11 TYR A 348
ASP A 223
VAL A 190
PHE A 233
ILE A 225
 None
 1.22A 5hwcA-5z0cA:
undetectable		 5hwcA-5z0cA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 GLY A  77
ILE A 314
ASP A 155
LEU A 157
ALA A 162
 None
 0.95A 5l0zA-5z0cA:
2.7		 5l0zA-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5z0c NEROL DEHYDROGENASE
(Persicaria
minor) 		5 / 12 GLY A 251
GLY A 180
LEU A 265
ASP A 250
MET A 249
 None
GOL  A 404 ( 4.2A)
None
None
None
 1.33A 5yn6A-5z0cA:
undetectable		 5yn6A-5z0cA:
undetectable