SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		3 / 3 TRP A 159
VAL A 260
TRP A 341
 None
None
MAL  A 501 (-2.7A)
 1.22A 1c4dA-5z0rA:
undetectable
1c4dB-5z0rA:
undetectable		 1c4dA-5z0rA:
undetectable
1c4dB-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		4 / 6 GLU A 215
ILE A  12
TYR A  18
GLY A  20
 None
 1.16A 1maaB-5z0rA:
undetectable
1maaD-5z0rA:
undetectable		 1maaB-5z0rA:
11.63
1maaD-5z0rA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 402
ILE A 413
TRP A 416
 None
 1.04A 1nodB-5z0rA:
undetectable		 1nodB-5z0rA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 305
SER A 307
TYR A 308
LEU A 291
 None
 1.14A 1xz1A-5z0rA:
undetectable		 1xz1A-5z0rA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 305
SER A 307
TYR A 308
LEU A 291
 None
 1.15A 1xz3A-5z0rA:
undetectable		 1xz3A-5z0rA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 336
LYS A 180
VAL A 182
 None
 0.91A 2jfaB-5z0rA:
undetectable		 2jfaB-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 402
ILE A 413
TRP A 416
 None
 1.01A 2nodB-5z0rA:
undetectable		 2nodB-5z0rA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		4 / 7 VAL A  98
ALA A 106
PHE A  93
PRO A  92
 None
 1.01A 2q6oA-5z0rA:
undetectable		 2q6oA-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		4 / 6 PHE A 259
ALA A 163
LEU A 248
PRO A 160
 None
 0.99A 3bgdA-5z0rA:
undetectable		 3bgdA-5z0rA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.56A 3bjwC-5z0rA:
undetectable		 3bjwC-5z0rA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		4 / 8 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.60A 3bjwA-5z0rA:
undetectable		 3bjwA-5z0rA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 402
ILE A 413
TRP A 416
 None
 1.12A 3e68A-5z0rA:
undetectable		 3e68A-5z0rA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 402
ILE A 413
TRP A 416
 None
 1.15A 3e6tB-5z0rA:
undetectable		 3e6tB-5z0rA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 VAL A 344
GLY A 188
ALA A 189
LEU A 193
LEU A 161
 None
 1.01A 3hs6A-5z0rA:
undetectable		 3hs6A-5z0rA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  61
ALA A 277
ASP A 268
ALA A 270
ILE A  10
 None
 1.09A 3jb1A-5z0rA:
undetectable		 3jb1A-5z0rA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		7 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
ARG A 345
 MAL  A 501 ( 3.7A)
MAL  A 501 (-3.5A)
MAL  A 501 (-3.6A)
MAL  A 501 (-2.9A)
MAL  A 501 ( 3.7A)
MAL  A 501 (-2.7A)
None
 0.70A 3jyrA-5z0rA:
37.2		 3jyrA-5z0rA:
60.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.34A 3vwqA-5z0rA:
undetectable		 3vwqA-5z0rA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 11 ALA A 232
ASP A 297
TYR A 211
ASN A 235
GLY A 229
 None
 1.34A 3vwrA-5z0rA:
undetectable		 3vwrA-5z0rA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		4 / 6 GLY A 261
GLU A 112
ASP A  15
ASP A  66
 MAL  A 501 ( 4.8A)
MAL  A 501 (-2.6A)
None
MAL  A 501 (-3.0A)
 1.02A 3vywC-5z0rA:
undetectable		 3vywC-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 9 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.17A 4or0B-5z0rA:
undetectable		 4or0B-5z0rA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 11 ILE A 133
LEU A 140
LEU A 123
ALA A 224
LEU A 116
 None
 1.10A 4p65E-5z0rA:
undetectable
4p65F-5z0rA:
undetectable
4p65J-5z0rA:
undetectable
4p65L-5z0rA:
undetectable		 4p65E-5z0rA:
undetectable
4p65F-5z0rA:
undetectable
4p65J-5z0rA:
undetectable
4p65L-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  57
GLY A  55
ALA A 270
ARG A 440
ILE A  61
 None
 0.97A 5bw4B-5z0rA:
undetectable		 5bw4B-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.34A 5w4zA-5z0rA:
undetectable		 5w4zA-5z0rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.36A 5w4zB-5z0rA:
undetectable		 5w4zB-5z0rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 261
LYS A 298
ASP A 297
VAL A 294
ILE A  12
 MAL  A 501 ( 4.8A)
None
None
None
None
 1.01A 5wz1A-5z0rA:
undetectable		 5wz1A-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 261
LYS A 298
ASP A 297
VAL A 294
ILE A  12
 MAL  A 501 ( 4.8A)
None
None
None
None
 1.02A 5wz1C-5z0rA:
undetectable		 5wz1C-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 261
LYS A 298
ASP A 297
VAL A 294
ILE A  12
 MAL  A 501 ( 4.8A)
None
None
None
None
 1.05A 5wz1D-5z0rA:
undetectable		 5wz1D-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 261
LYS A 298
ASP A 297
VAL A 294
ILE A  12
 MAL  A 501 ( 4.8A)
None
None
None
None
 1.04A 5wz1E-5z0rA:
undetectable		 5wz1E-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 261
LYS A 298
ASP A 297
VAL A 294
ILE A  12
 MAL  A 501 ( 4.8A)
None
None
None
None
 1.05A 5wz1F-5z0rA:
undetectable		 5wz1F-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 261
LYS A 298
ASP A 297
VAL A 294
ILE A  12
 MAL  A 501 ( 4.8A)
None
None
None
None
 1.01A 5wz1G-5z0rA:
undetectable		 5wz1G-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 261
LYS A 298
ASP A 297
VAL A 294
ILE A  12
 MAL  A 501 ( 4.8A)
None
None
None
None
 1.03A 5wz1H-5z0rA:
undetectable		 5wz1H-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 156
ASN A 228
LEU A 114
 MAL  A 501 (-2.9A)
None
None
 0.78A 6b58A-5z0rA:
undetectable		 6b58A-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN
(Escherichia
coli) 		5 / 11 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.32A 6bm5A-5z0rA:
undetectable		 6bm5A-5z0rA:
undetectable