SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 9 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.29A 1bkfA-5z0yA:
undetectable
1bkfA-5z0yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 12 ILE A 374
ILE A 417
ALA A 424
LEU A 355
ILE A 360
None
1.17A 1bsxA-5z0yA:
undetectable
1bsxA-5z0yA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 12 ILE A 374
ILE A 417
ALA A 424
LEU A 355
ILE A 360
None
1.17A 1bsxB-5z0yA:
undetectable
1bsxB-5z0yA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 12 ALA A 307
GLN A  89
THR A 245
ASN A 106
THR A 306
None
1.17A 1dhfA-5z0yA:
undetectable
1dhfA-5z0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
4 / 5 ARG A 199
ALA A 327
LYS A 328
GLU A 331
None
1.22A 1e7cA-5z0yA:
undetectable
1e7cA-5z0yA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.36A 1fkfA-5z0yA:
undetectable
1fkfA-5z0yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.36A 1fkjA-5z0yA:
undetectable
1fkjA-5z0yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 9 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.33A 1q6iA-5z0yA:
undetectable
1q6iA-5z0yA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.36A 1q6iB-5z0yA:
undetectable
1q6iB-5z0yA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.39A 1tcoC-5z0yA:
undetectable
1tcoC-5z0yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.32A 1yatA-5z0yA:
undetectable
1yatA-5z0yA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.25A 2dg3A-5z0yA:
undetectable
2dg3A-5z0yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.23A 2dg4A-5z0yA:
undetectable
2dg4A-5z0yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.35A 2fkeA-5z0yA:
undetectable
2fkeA-5z0yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
ILE A 395
CYH A 369
PHE A 334
None
1.50A 2vn1B-5z0yA:
undetectable
2vn1B-5z0yA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.32A 2vn1B-5z0yA:
undetectable
2vn1B-5z0yA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.34A 3ihzA-5z0yA:
undetectable
3ihzA-5z0yA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
LEU A 355
ILE A 395
PHE A 334
None
1.11A 3kz7A-5z0yA:
undetectable
3kz7A-5z0yA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.29A 3kz7A-5z0yA:
undetectable
3kz7A-5z0yA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.35A 3o5rA-5z0yA:
undetectable
3o5rA-5z0yA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.29A 3uf8A-5z0yA:
undetectable
3uf8A-5z0yA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
VAL A 393
ILE A 395
ILE A 413
PHE A 334
None
1.45A 3uf8A-5z0yA:
undetectable
3uf8A-5z0yA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
4 / 5 LEU A  93
ALA A  95
MET A 258
PHE A  96
None
1.01A 3uq6A-5z0yA:
undetectable
3uq6A-5z0yA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.30A 3uqaA-5z0yA:
undetectable
3uqaA-5z0yA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.29A 3vawA-5z0yA:
undetectable
3vawA-5z0yA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
4 / 5 LEU A  93
ALA A  95
MET A 258
PHE A  96
None
0.99A 4dc3B-5z0yA:
undetectable
4dc3B-5z0yA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 12 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.24A 4drhA-5z0yA:
undetectable
4drhA-5z0yA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 12 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.27A 4drhD-5z0yA:
undetectable
4drhD-5z0yA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.25A 4driA-5z0yA:
undetectable
4driA-5z0yA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.25A 4drjA-5z0yA:
undetectable
4drjA-5z0yA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.27A 4dz2A-5z0yA:
undetectable
4dz2B-5z0yA:
undetectable
4dz2A-5z0yA:
19.64
4dz2B-5z0yA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.28A 4dz2A-5z0yA:
undetectable
4dz2B-5z0yA:
undetectable
4dz2A-5z0yA:
19.64
4dz2B-5z0yA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.31A 4dz3A-5z0yA:
undetectable
4dz3A-5z0yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.31A 4dz3B-5z0yA:
undetectable
4dz3B-5z0yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
4 / 6 PHE A 260
PHE A 237
ALA A  95
LEU A 251
None
1.04A 4ejgD-5z0yA:
undetectable
4ejgD-5z0yA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
4 / 6 SER A 348
ASP A 347
ARG A 199
GLU A 331
None
1.00A 4eysA-5z0yA:
undetectable
4eysA-5z0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 GLN A 320
ALA A 311
ALA A 229
ALA A  95
VAL A 105
None
1.07A 4j6cA-5z0yA:
undetectable
4j6cA-5z0yA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.31A 4laxA-5z0yA:
undetectable
4laxA-5z0yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 12 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.32A 4nnrA-5z0yA:
undetectable
4nnrB-5z0yA:
undetectable
4nnrA-5z0yA:
22.38
4nnrB-5z0yA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.32A 4nnrB-5z0yA:
undetectable
4nnrB-5z0yA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.27A 4qt2A-5z0yA:
undetectable
4qt2A-5z0yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.27A 4qt3A-5z0yA:
undetectable
4qt3A-5z0yA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
LEU A 355
ILE A 395
PHE A 334
None
1.12A 5d75A-5z0yA:
undetectable
5d75A-5z0yA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
3 / 3 ASP A 384
LEU A 438
ARG A 364
None
0.93A 5e8qA-5z0yA:
2.2
5e8qA-5z0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
LEU A 355
ILE A 395
PHE A 334
None
1.11A 5gpgA-5z0yA:
undetectable
5gpgA-5z0yA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
LEU A 355
LYS A 378
ILE A 395
PHE A 334
None
1.09A 5gpgA-5z0yA:
undetectable
5gpgA-5z0yA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.27A 5huaA-5z0yA:
undetectable
5huaA-5z0yA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
6 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
LEU A 330
PHE A 334
None
1.32A 5hw8C-5z0yA:
undetectable
5hw8H-5z0yA:
undetectable
5hw8C-5z0yA:
18.90
5hw8H-5z0yA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
ILE A 395
ILE A 374
PHE A 334
None
1.18A 5hw8G-5z0yA:
undetectable
5hw8G-5z0yA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 11 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.26A 5hwcA-5z0yA:
undetectable
5hwcA-5z0yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 12 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.29A 6mkeA-5z0yA:
undetectable
6mkeD-5z0yA:
undetectable
6mkeA-5z0yA:
25.84
6mkeD-5z0yA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 12 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.27A 6mkeB-5z0yA:
undetectable
6mkeC-5z0yA:
undetectable
6mkeB-5z0yA:
25.84
6mkeC-5z0yA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.29A 6mkeC-5z0yA:
undetectable
6mkeC-5z0yA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii)
5 / 10 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.29A 6mkeD-5z0yA:
undetectable
6mkeD-5z0yA:
25.84