SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN
(Mus
musculus) 		3 / 3 TRP A 293
ARG A 204
PHE A 237
 None
 1.31A 1zeaH-5z1wA:
undetectable
1zeaL-5z1wA:
undetectable		 1zeaH-5z1wA:
undetectable
1zeaL-5z1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN
(Mus
musculus) 		3 / 3 ARG A 204
GLY A 238
PRO A 239
 None
 0.71A 2hreD-5z1wA:
undetectable		 2hreD-5z1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN
(Mus
musculus) 		5 / 9 VAL A 548
PHE A 547
PHE A 517
ILE A 520
PHE A 488
 None
 1.26A 3me6D-5z1wA:
1.5		 3me6D-5z1wA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN
(Mus
musculus) 		4 / 8 THR A 298
ARG A 299
GLY A 269
SER A 266
 None
 0.92A 3tzfB-5z1wA:
undetectable		 3tzfB-5z1wA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN
(Mus
musculus) 		3 / 3 SER A 256
GLY A 255
GLN A 250
 None
 0.60A 3v4tH-5z1wA:
undetectable		 3v4tH-5z1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN
(Mus
musculus) 		5 / 10 VAL A 322
PHE A 324
SER A 153
SER A 152
GLY A 329
 None
 1.43A 4xp1A-5z1wA:
1.9		 4xp1A-5z1wA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN
(Mus
musculus) 		4 / 5 LEU A 200
GLN A 202
PHE A 302
PHE A 160
 None
 1.29A 6nmpP-5z1wA:
6.6
6nmpW-5z1wA:
undetectable		 6nmpP-5z1wA:
undetectable
6nmpW-5z1wA:
undetectable