SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		4 / 7 THR A  77
LEU A  75
GLY A   8
LEU A  33
 None
 0.98A 1gtiE-5z2eA:
undetectable		 1gtiE-5z2eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		6 / 11 GLY A 259
ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.21A 1n49B-5z2eA:
undetectable		 1n49B-5z2eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		6 / 11 GLY A 259
ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.21A 1n49C-5z2eA:
undetectable		 1n49C-5z2eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 ALA A  17
LEU A  75
PHE A 127
PHE A 239
THR A  20
 None
 1.19A 2w3mB-5z2eA:
undetectable		 2w3mB-5z2eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 10 PHE A  72
LEU A  60
ASP A  74
HIS A  84
ALA A   5
 None
 1.34A 2wt9A-5z2eA:
5.3		 2wt9A-5z2eA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 LEU A  73
ASP A  34
VAL A  32
VAL A   4
ILE A   6
 None
 0.95A 3d20B-5z2eA:
undetectable		 3d20B-5z2eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		6 / 10 GLY A 259
ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.41A 3ekvA-5z2eA:
undetectable		 3ekvA-5z2eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 LEU A  73
ASP A  34
VAL A  32
VAL A   4
ILE A   6
 None
 0.99A 3k4vC-5z2eA:
undetectable		 3k4vC-5z2eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 LEU A  73
ASP A  34
VAL A  32
VAL A   4
ILE A   6
 None
 1.04A 3mwsB-5z2eA:
undetectable		 3mwsB-5z2eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 LEU A  73
ASP A  34
VAL A  32
VAL A   4
ILE A   6
 None
 1.01A 3nduC-5z2eA:
undetectable		 3nduC-5z2eA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 GLY A 259
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.03A 3ndwA-5z2eA:
undetectable		 3ndwA-5z2eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		6 / 11 GLY A 259
ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.44A 3nu3B-5z2eA:
undetectable		 3nu3B-5z2eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		6 / 9 GLY A 259
ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.40A 3nujB-5z2eA:
undetectable		 3nujB-5z2eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		6 / 9 GLY A 259
ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.45A 3nuoB-5z2eA:
undetectable		 3nuoB-5z2eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 10 LEU A  73
ASP A  34
VAL A  32
VAL A   4
ILE A   6
 None
 1.03A 3oxwD-5z2eA:
undetectable		 3oxwD-5z2eA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 LEU A  73
ASP A  34
VAL A  32
VAL A   4
ILE A   6
 None
 1.04A 3pwmA-5z2eA:
undetectable		 3pwmA-5z2eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 11 PHE A  72
LEU A  60
ASP A  74
HIS A  84
ALA A   5
 None
 1.37A 3r2jB-5z2eA:
undetectable		 3r2jB-5z2eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 PHE A  72
LEU A  60
ASP A  74
HIS A  84
ALA A   5
 None
 1.34A 3r2jC-5z2eA:
6.0		 3r2jC-5z2eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 11 PHE A  72
LEU A  60
ASP A  74
HIS A  84
ALA A   5
 None
 1.37A 3r2jD-5z2eA:
5.9		 3r2jD-5z2eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 11 SER A 246
ILE A 247
VAL A  71
PHE A  72
VAL A   4
 None
 0.99A 3rf4A-5z2eA:
undetectable
3rf4C-5z2eA:
2.4		 3rf4A-5z2eA:
24.35
3rf4C-5z2eA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 11 SER A 246
ILE A 247
VAL A  71
PHE A  72
VAL A   4
 None
 1.01A 3rf4A-5z2eA:
undetectable
3rf4B-5z2eA:
2.2		 3rf4A-5z2eA:
24.35
3rf4B-5z2eA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 11 SER A 246
ILE A 247
VAL A  71
PHE A  72
VAL A   4
 None
 0.97A 3rf4B-5z2eA:
2.2
3rf4C-5z2eA:
2.4		 3rf4B-5z2eA:
24.35
3rf4C-5z2eA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 10 ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 0.95A 4njuB-5z2eA:
undetectable		 4njuB-5z2eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 10 ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 0.95A 4njuD-5z2eA:
undetectable		 4njuD-5z2eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		6 / 9 GLY A 259
ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.48A 4rvjB-5z2eA:
undetectable		 4rvjB-5z2eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		6 / 9 GLY A 259
ALA A 124
VAL A  96
GLY A 242
ILE A 129
ILE A 122
 None
 1.46A 4rvjD-5z2eA:
undetectable		 4rvjD-5z2eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		4 / 7 ASP A  74
ILE A  97
GLY A 101
THR A  76
 None
 1.06A 4zxiA-5z2eA:
4.6		 4zxiA-5z2eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		4 / 7 ILE A   6
LEU A  75
GLY A  11
GLY A  14
 None
 0.85A 5a06B-5z2eA:
14.0		 5a06B-5z2eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		4 / 4 VAL A  71
ILE A   6
ASN A  24
VAL A 243
 None
 1.09A 5ajqA-5z2eA:
undetectable		 5ajqA-5z2eA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		4 / 8 LEU A  63
ARG A   3
HIS A  84
LEU A  87
 None
 0.89A 5dxeA-5z2eA:
undetectable		 5dxeA-5z2eA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		5 / 12 PHE A  72
LEU A 119
GLY A 120
VAL A  81
ILE A  97
 None
 1.05A 6bxmA-5z2eA:
3.6		 6bxmA-5z2eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5z2e DIHYDRODIPICOLINATE
REDUCTASE
(Paenisporosarcin
a
sp.
TG-14) 		4 / 8 LEU A  63
ARG A   3
HIS A  84
LEU A  87
 None
 0.89A 6cbzA-5z2eA:
undetectable		 6cbzA-5z2eA:
19.78