SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 8 GLY A 257
GLU A 254
PHE A 379
HIS A 377
None
0.95A 1ax9A-5z2gA:
undetectable
1ax9A-5z2gA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 8 GLY A 258
GLU A 254
PHE A 379
HIS A 377
None
0.92A 1ax9A-5z2gA:
undetectable
1ax9A-5z2gA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 12 GLU A 186
TYR A 199
TYR A 207
GLY A 212
TYR A 202
None
1.13A 1httB-5z2gA:
2.5
1httB-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 5 SER A 381
THR A 380
PHE A 379
GLY A 384
None
1.11A 1icrA-5z2gA:
undetectable
1icrB-5z2gA:
undetectable
1icrA-5z2gA:
20.69
1icrB-5z2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 6 SER A 381
THR A 380
PHE A 379
GLY A 384
None
1.13A 1icuA-5z2gA:
undetectable
1icuB-5z2gA:
undetectable
1icuA-5z2gA:
20.69
1icuB-5z2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 6 SER A 381
THR A 380
PHE A 379
GLY A 384
None
1.14A 1icuC-5z2gA:
undetectable
1icuD-5z2gA:
undetectable
1icuC-5z2gA:
20.69
1icuD-5z2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 5 GLY A 384
SER A 381
THR A 380
PHE A 379
None
1.18A 1icuC-5z2gA:
undetectable
1icuD-5z2gA:
undetectable
1icuC-5z2gA:
20.69
1icuD-5z2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 5 GLY A 384
SER A 381
THR A 380
PHE A 379
None
1.15A 1icvA-5z2gA:
undetectable
1icvB-5z2gA:
undetectable
1icvA-5z2gA:
20.69
1icvB-5z2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 5 SER A 381
THR A 380
PHE A 379
GLY A 384
None
1.14A 1icvC-5z2gA:
undetectable
1icvD-5z2gA:
undetectable
1icvC-5z2gA:
20.69
1icvD-5z2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 5 GLY A 384
SER A 381
THR A 380
PHE A 379
None
1.14A 1icvC-5z2gA:
undetectable
1icvD-5z2gA:
undetectable
1icvC-5z2gA:
20.69
1icvD-5z2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 6 GLY A 384
SER A 381
THR A 380
PHE A 379
None
1.09A 1kqbC-5z2gA:
undetectable
1kqbD-5z2gA:
undetectable
1kqbC-5z2gA:
undetectable
1kqbD-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 6 GLU A 112
LEU A 110
ARG A 251
PHE A 252
None
0.97A 1s8fB-5z2gA:
2.2
1s8fB-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
6 / 7 ARG A 109
ASN A 227
PHE A 246
TYR A 389
ILE A 446
TRP A 481
None
None
None
None
FAD  A 604 (-4.5A)
FAD  A 604 (-4.7A)
0.47A 1tdnA-5z2gA:
59.6
1tdnA-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 12 ILE A 121
GLN A 261
ASN A 129
PHE A 259
LEU A 262
None
None
NAG  A 602 ( 4.4A)
None
None
1.03A 1xdkA-5z2gA:
undetectable
1xdkA-5z2gA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
3 / 3 THR A 488
GLU A  32
HIS A 114
None
0.84A 1xwfA-5z2gA:
undetectable
1xwfA-5z2gA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
3 / 3 THR A 488
GLU A  32
HIS A 114
None
0.82A 1xwfB-5z2gA:
undetectable
1xwfB-5z2gA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
3 / 3 THR A 488
GLU A  32
HIS A 114
None
0.83A 1xwfC-5z2gA:
undetectable
1xwfC-5z2gA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
3 / 3 THR A 488
GLU A  32
HIS A 114
None
0.80A 1xwfD-5z2gA:
undetectable
1xwfD-5z2gA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 7 GLY A 257
GLU A 254
PHE A 379
HIS A 377
None
0.91A 2ackA-5z2gA:
undetectable
2ackA-5z2gA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 7 GLY A 258
GLU A 254
PHE A 379
HIS A 377
None
0.89A 2ackA-5z2gA:
undetectable
2ackA-5z2gA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
3 / 3 HIS A 373
MET A 108
MET A 387
None
1.32A 2vj1A-5z2gA:
undetectable
2vj1A-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
3 / 3 TYR A 338
ARG A  90
SER A 445
None
FAD  A 604 (-3.6A)
None
1.17A 4dr2I-5z2gA:
undetectable
4dr2J-5z2gA:
undetectable
4dr2I-5z2gA:
19.08
4dr2J-5z2gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
3 / 3 LYS A 164
PRO A 165
SER A 166
NAG  A 603 (-2.8A)
None
None
0.42A 4k50I-5z2gA:
undetectable
4k50I-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
3 / 3 LEU A 208
LYS A 205
THR A 204
None
0.62A 4lj0A-5z2gA:
undetectable
4lj0A-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 8 ALA A 471
GLY A 489
ALA A  67
GLY A  64
None
0.70A 4zjzA-5z2gA:
undetectable
4zjzA-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 12 THR A 475
THR A 485
CYH A 310
ALA A 462
ALA A 492
None
FAD  A 604 (-3.5A)
None
None
None
1.27A 5d0xH-5z2gA:
undetectable
5d0xI-5z2gA:
undetectable
5d0xH-5z2gA:
15.09
5d0xI-5z2gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 7 LEU A  80
GLY A  64
ALA A  63
SER A  66
None
None
FAD  A 604 (-3.5A)
None
0.88A 5f1aB-5z2gA:
undetectable
5f1aB-5z2gA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 12 ASP A 243
ALA A 244
GLY A 480
THR A 485
SER A 242
None
None
FAD  A 604 (-4.0A)
FAD  A 604 (-3.5A)
None
1.21A 5hfjD-5z2gA:
undetectable
5hfjD-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 12 ASP A 243
ALA A 244
GLY A 480
THR A 485
SER A 242
None
None
FAD  A 604 (-4.0A)
FAD  A 604 (-3.5A)
None
1.22A 5hfjH-5z2gA:
undetectable
5hfjH-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 12 GLY A 480
PHE A  30
ALA A 244
ILE A 116
PHE A  38
FAD  A 604 (-4.0A)
None
None
None
None
1.14A 5igyA-5z2gA:
undetectable
5igyA-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 12 THR A 475
THR A 485
CYH A 310
ALA A 462
ALA A 492
None
FAD  A 604 (-3.5A)
None
None
None
1.27A 5l5zH-5z2gA:
undetectable
5l5zI-5z2gA:
undetectable
5l5zH-5z2gA:
15.09
5l5zI-5z2gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 12 THR A 475
THR A 485
CYH A 310
ALA A 462
ALA A 492
None
FAD  A 604 (-3.5A)
None
None
None
1.28A 5l5zV-5z2gA:
undetectable
5l5zW-5z2gA:
undetectable
5l5zV-5z2gA:
15.09
5l5zW-5z2gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 11 VAL A  58
GLY A  59
GLU A  82
SER A  84
SER A 311
FAD  A 604 (-4.5A)
FAD  A 604 (-3.2A)
FAD  A 604 (-2.7A)
FAD  A 604 ( 4.0A)
FAD  A 604 (-4.2A)
1.04A 5x6yC-5z2gA:
undetectable
5x6yC-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
4 / 5 ILE A 283
PHE A 321
ARG A 318
THR A 312
None
None
None
FAD  A 604 (-4.4A)
1.06A 5z84N-5z2gA:
undetectable
5z84W-5z2gA:
undetectable
5z84N-5z2gA:
undetectable
5z84W-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 10 PHE A 398
LEU A 401
ASP A 402
ILE A 344
ILE A 409
None
0.99A 6ebpD-5z2gA:
undetectable
6ebpD-5z2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 11 PHE A 398
LEU A 401
ASP A 402
ILE A 344
ILE A 409
None
0.98A 6ebzA-5z2gA:
undetectable
6ebzA-5z2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 11 PHE A 398
LEU A 401
ASP A 402
ILE A 344
ILE A 409
None
0.96A 6ebzB-5z2gA:
undetectable
6ebzB-5z2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 11 PHE A 398
LEU A 401
ASP A 402
ILE A 344
ILE A 409
None
1.01A 6ebzC-5z2gA:
undetectable
6ebzC-5z2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 11 PHE A 398
LEU A 401
ASP A 402
ILE A 344
ILE A 409
None
0.95A 6ebzD-5z2gA:
undetectable
6ebzD-5z2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 11 PHE A 398
LEU A 401
ASP A 402
ILE A 344
ILE A 409
None
0.94A 6gp2A-5z2gA:
undetectable
6gp2A-5z2gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)
5z2g L-AMINO ACID OXIDASE
(Naja
atra)
5 / 11 PHE A 398
LEU A 401
ASP A 402
ILE A 344
ILE A 409
None
0.96A 6gp2B-5z2gA:
undetectable
6gp2B-5z2gA:
18.09