SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		5 / 9 ALA A 136
ASN A 133
GLY A 113
PHE A 115
GLY A 130
 None
 1.42A 1ru9H-5z3rA:
undetectable
1ru9L-5z3rA:
undetectable		 1ru9H-5z3rA:
undetectable
1ru9L-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		5 / 10 ALA A 136
ASN A 133
GLY A 113
PHE A 115
GLY A 130
 None
 1.43A 1ruaH-5z3rA:
undetectable
1ruaL-5z3rA:
undetectable		 1ruaH-5z3rA:
undetectable
1ruaL-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		4 / 6 LEU A  64
PHE A  67
ALA A  66
LEU A  33
 None
 0.98A 1ukbA-5z3rA:
undetectable		 1ukbA-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		8 / 11 SER A  20
TRP A  32
ASP A  44
ILE A  72
LEU A  77
LEU A  97
LEU A  99
TYR A 117
 None
 0.89A 2a15A-5z3rA:
24.7		 2a15A-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		6 / 11 TRP A  21
VAL A  24
TRP A  32
ILE A  72
LEU A  77
LEU A  97
 None
 1.37A 2a15A-5z3rA:
24.7		 2a15A-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		8 / 11 VAL A  24
TRP A  32
ASP A  44
ILE A  72
LEU A  77
LEU A  97
LEU A  99
TYR A 117
 None
 0.89A 2a15A-5z3rA:
24.7		 2a15A-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z77_D_NCAD200_0
(PUTATIVE STEROID
ISOMERASE)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		8 / 9 SER A  20
TRP A  21
TRP A  32
ASP A  44
LEU A  77
LEU A  97
LEU A  99
TYR A 117
 None
 0.79A 2z77D-5z3rA:
25.1		 2z77D-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		5 / 12 ASN A  52
GLY A  57
VAL A 111
LEU A  99
GLY A 130
 None
 1.18A 5vopB-5z3rA:
undetectable		 5vopB-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5z3r STEROID
DELTA-ISOMERASE
(Mycolicibacteriu
m
neoaurum) 		5 / 12 THR A 140
VAL A 108
GLU A 100
VAL A  98
GLU A  82
 None
 1.35A 6bzoC-5z3rA:
1.4		 6bzoC-5z3rA:
undetectable