SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5z43 AMBP1
(Fischerella
ambigua) 		5 / 12 VAL A 107
TYR A 162
LEU A 115
ILE A  93
GLY A  70
 None
 0.96A 1cqeA-5z43A:
undetectable		 1cqeA-5z43A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5z43 AMBP1
(Fischerella
ambigua) 		5 / 12 VAL A 107
TYR A 162
LEU A 115
ILE A  93
GLY A  70
 None
 0.96A 1cqeB-5z43A:
undetectable		 1cqeB-5z43A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5z43 AMBP1
(Fischerella
ambigua) 		5 / 12 VAL A 107
TYR A 162
LEU A 115
ILE A  93
GLY A  70
 None
 1.04A 3kk6A-5z43A:
undetectable		 3kk6A-5z43A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5z43 AMBP1
(Fischerella
ambigua) 		5 / 12 VAL A 107
TYR A 162
LEU A 115
ILE A  93
GLY A  70
 None
 1.01A 3kk6B-5z43A:
undetectable		 3kk6B-5z43A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 7 LEU A 152
ASP A 153
ALA A 154
TYR A 183
 None
 1.10A 3rodD-5z43A:
undetectable		 3rodD-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 8 PHE A 158
LEU A 136
LEU A 155
PHE A 171
 None
 0.84A 4qopC-5z43A:
undetectable		 4qopC-5z43A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5z43 AMBP1
(Fischerella
ambigua) 		5 / 12 LEU A 263
GLY A 264
TYR A 276
TYR A 248
LEU A 241
 None
 1.27A 5czyA-5z43A:
undetectable		 5czyA-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 8 ALA A 252
ASN A 250
ARG A 233
THR A  47
 None
 1.27A 5db5A-5z43A:
undetectable
5db5B-5z43A:
undetectable		 5db5A-5z43A:
undetectable
5db5B-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 7 ILE A 160
GLY A 159
ASP A 108
PHE A  59
 None
 0.91A 5hieA-5z43A:
undetectable		 5hieA-5z43A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 4 GLU A  95
PRO A  94
ILE A  93
LEU A  92
 None
 1.15A 5m45A-5z43A:
undetectable		 5m45A-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 4 GLU A  95
PRO A  94
ILE A  93
LEU A  92
 None
 1.21A 5m45D-5z43A:
undetectable		 5m45D-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 4 GLU A  95
PRO A  94
ILE A  93
LEU A  92
 None
 1.15A 5m45G-5z43A:
undetectable		 5m45G-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 4 GLU A  95
PRO A  94
ILE A  93
LEU A  92
 None
 1.22A 5m45J-5z43A:
undetectable		 5m45J-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5z43 AMBP1
(Fischerella
ambigua) 		3 / 3 HIS A 178
HIS A 175
HIS A 151
 None
 0.97A 5oexA-5z43A:
undetectable		 5oexA-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5z43 AMBP1
(Fischerella
ambigua) 		5 / 12 GLU A  95
VAL A 126
LEU A 155
SER A 135
PHE A 216
 None
 1.10A 5vooB-5z43A:
undetectable		 5vooB-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5z43 AMBP1
(Fischerella
ambigua) 		5 / 12 GLU A  95
VAL A 126
LEU A 155
SER A 135
PHE A 216
 None
 1.20A 5vooC-5z43A:
undetectable		 5vooC-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5z43 AMBP1
(Fischerella
ambigua) 		4 / 7 HIS A  62
ASP A 172
TYR A 170
LEU A 155
 None
 1.17A 6nmfA-5z43A:
undetectable
6nmfC-5z43A:
undetectable
6nmfP-5z43A:
undetectable		 6nmfA-5z43A:
undetectable
6nmfC-5z43A:
undetectable
6nmfP-5z43A:
undetectable