SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.96A 1v54A-5z4iA:
undetectable
1v54J-5z4iA:
undetectable		 1v54A-5z4iA:
undetectable
1v54J-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.98A 2dyrA-5z4iA:
undetectable
2dyrJ-5z4iA:
undetectable		 2dyrA-5z4iA:
undetectable
2dyrJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 7 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.95A 2dyrN-5z4iA:
undetectable
2dyrW-5z4iA:
undetectable		 2dyrN-5z4iA:
undetectable
2dyrW-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 1.00A 2dysA-5z4iA:
undetectable
2dysJ-5z4iA:
undetectable		 2dysA-5z4iA:
undetectable
2dysJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.90A 2dysN-5z4iA:
undetectable
2dysW-5z4iA:
undetectable		 2dysN-5z4iA:
undetectable
2dysW-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.97A 2eijA-5z4iA:
undetectable
2eijJ-5z4iA:
undetectable		 2eijA-5z4iA:
undetectable
2eijJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.92A 2eilA-5z4iA:
undetectable
2eilJ-5z4iA:
undetectable		 2eilA-5z4iA:
undetectable
2eilJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.97A 2zxwA-5z4iA:
undetectable
2zxwJ-5z4iA:
undetectable		 2zxwA-5z4iA:
undetectable
2zxwJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 8 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.92A 3ablN-5z4iA:
undetectable
3ablW-5z4iA:
undetectable		 3ablN-5z4iA:
undetectable
3ablW-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.96A 3asnA-5z4iA:
undetectable
3asnJ-5z4iA:
undetectable		 3asnA-5z4iA:
undetectable
3asnJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 6 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.97A 3asoA-5z4iA:
undetectable
3asoJ-5z4iA:
undetectable		 3asoA-5z4iA:
undetectable
3asoJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		3 / 3 ARG A  80
THR A  73
TRP A  82
 None
 1.13A 4d7hA-5z4iA:
undetectable		 4d7hA-5z4iA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		3 / 3 ASP A  59
ARG A  80
THR A  62
 None
 0.84A 4i13A-5z4iA:
undetectable		 4i13A-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		3 / 3 ASP A  59
ARG A  80
THR A  62
 None
 0.84A 4p3rA-5z4iA:
undetectable		 4p3rA-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		3 / 3 ARG A  80
THR A  73
TRP A  82
 None
 1.09A 4ug5A-5z4iA:
undetectable		 4ug5A-5z4iA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		3 / 3 ARG A  80
THR A  73
TRP A  82
 None
 1.10A 4uglA-5z4iA:
undetectable		 4uglA-5z4iA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		3 / 3 ARG A  80
THR A  73
TRP A  82
 None
 1.10A 5g6cA-5z4iA:
undetectable		 5g6cA-5z4iA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		3 / 3 GLY A  54
ASN A  39
ARG A  80
 None
 0.69A 5w7bD-5z4iA:
undetectable		 5w7bD-5z4iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 8 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.89A 5xdxN-5z4iA:
undetectable
5xdxW-5z4iA:
undetectable		 5xdxN-5z4iA:
undetectable
5xdxW-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 7 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.92A 6nmfA-5z4iA:
undetectable
6nmfJ-5z4iA:
undetectable		 6nmfA-5z4iA:
undetectable
6nmfJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20
(Homo
sapiens) 		4 / 5 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.89A 6nmpN-5z4iA:
undetectable
6nmpW-5z4iA:
undetectable		 6nmpN-5z4iA:
undetectable
6nmpW-5z4iA:
undetectable