SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5z59 PROTEIN-TYROSINE
PHOSPHATASE
(Thermococcus
kodakarensis) 		4 / 4 GLY A  98
LEU A  97
GLY A 101
ARG A 127
 None
 1.05A 1j7kA-5z59A:
undetectable		 1j7kA-5z59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5z59 PROTEIN-TYROSINE
PHOSPHATASE
(Thermococcus
kodakarensis) 		4 / 5 TYR A 110
SER A 111
GLU A 122
ASP A   9
 None
 1.30A 4xueA-5z59A:
undetectable		 4xueA-5z59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5z59 PROTEIN-TYROSINE
PHOSPHATASE
(Thermococcus
kodakarensis) 		4 / 4 TYR A 110
SER A 111
GLU A 122
ASP A   9
 None
 1.32A 5lsaA-5z59A:
undetectable		 5lsaA-5z59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5z59 PROTEIN-TYROSINE
PHOSPHATASE
(Thermococcus
kodakarensis) 		5 / 10 LEU A  97
GLY A 101
GLY A 104
ARG A 124
ALA A 130
 None
 1.14A 5o96E-5z59A:
undetectable
5o96F-5z59A:
undetectable		 5o96E-5z59A:
undetectable
5o96F-5z59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5z59 PROTEIN-TYROSINE
PHOSPHATASE
(Thermococcus
kodakarensis) 		3 / 3 TYR A  44
HIS A  92
MET A  94
 None
 1.16A 6af6A-5z59A:
undetectable		 6af6A-5z59A:
undetectable