SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 10 GLY A 191
SER A 154
MET A 190
LEU A 238
LEU A 151
 MLY  A 194 ( 4.6A)
None
MLY  A 240 ( 3.5A)
None
None
 1.40A 1a8uA-5z5cA:
undetectable		 1a8uA-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 10 GLY A 191
SER A 154
MET A 190
LEU A 238
LEU A 151
 MLY  A 194 ( 4.6A)
None
MLY  A 240 ( 3.5A)
None
None
 1.40A 1a8uB-5z5cA:
undetectable		 1a8uB-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 8 ARG A 104
SER A 101
SER A  74
LYS A  46
 MLY  A 303 ( 4.0A)
MLY  A 303 ( 2.7A)
CL  A 402 (-2.9A)
PLP  A 401 ( 1.3A)
 1.02A 1hwkA-5z5cA:
undetectable		 1hwkA-5z5cA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 8 ARG A 104
SER A 101
SER A  74
LYS A  46
 MLY  A 303 ( 4.0A)
MLY  A 303 ( 2.7A)
CL  A 402 (-2.9A)
PLP  A 401 ( 1.3A)
 1.04A 1hwkC-5z5cA:
undetectable		 1hwkC-5z5cA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 8 ARG A 104
SER A 101
SER A  74
LYS A  46
 MLY  A 303 ( 4.0A)
MLY  A 303 ( 2.7A)
CL  A 402 (-2.9A)
PLP  A 401 ( 1.3A)
 1.05A 1hwkD-5z5cA:
undetectable		 1hwkD-5z5cA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 8 ASP A 232
ILE A 271
GLY A 270
GLY A  75
 None
 0.77A 1me7A-5z5cA:
undetectable		 1me7A-5z5cA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 12 ARG A 104
ALA A 113
ILE A  69
GLY A  85
ILE A  94
 MLY  A 303 ( 4.0A)
MLY  A 114 ( 3.1A)
None
None
MLY  A 114 ( 4.5A)
 1.12A 2o4kA-5z5cA:
undetectable		 2o4kA-5z5cA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 8 GLY A 186
VAL A 183
LEU A 216
PRO A 207
 PLP  A 401 (-3.5A)
PLP  A 401 (-4.0A)
None
None
 1.09A 3bgdB-5z5cA:
2.8		 3bgdB-5z5cA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 5 LYS A 205
PRO A 207
SER A 217
LEU A 283
 MLY  A 204 ( 3.3A)
None
None
None
 1.38A 3ijxH-5z5cA:
undetectable		 3ijxH-5z5cA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 5 LYS A 205
PRO A 207
SER A 217
LEU A 283
 MLY  A 204 ( 3.3A)
None
None
None
 1.31A 3iluH-5z5cA:
undetectable		 3iluH-5z5cA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 5 PRO A 298
ASN A 276
ILE A 230
VAL A 250
 PLP  A 401 (-4.3A)
None
PLP  A 401 (-4.8A)
None
 1.33A 4hytA-5z5cA:
3.7		 4hytA-5z5cA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 7 ASN A  11
LYS A   6
TYR A 159
LEU A 163
 MLY  A   7 ( 4.4A)
MLY  A   7 ( 1.3A)
None
None
 1.24A 4yv5A-5z5cA:
undetectable		 4yv5A-5z5cA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 7 ASN A  11
LYS A   6
TYR A 159
LEU A 163
 MLY  A   7 ( 4.4A)
MLY  A   7 ( 1.3A)
None
None
 1.22A 4yv5B-5z5cA:
undetectable		 4yv5B-5z5cA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		3 / 3 ASP A  47
ASN A 153
GLN A 147
 None
PLP  A 401 ( 4.7A)
CL  A 402 (-3.5A)
 0.75A 5k7uA-5z5cA:
undetectable		 5k7uA-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 7 THR A  73
LEU A  54
VAL A  13
GLU A 155
 CL  A 402 (-4.1A)
MLY  A  55 ( 4.2A)
None
None
 0.94A 5tudA-5z5cA:
undetectable		 5tudA-5z5cA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 7 THR A 215
HIS A 225
PRO A 210
ILE A 227
 MLY  A 221 ( 3.1A)
MLY  A 224 ( 4.8A)
None
None
 1.22A 5vkqA-5z5cA:
undetectable
5vkqB-5z5cA:
undetectable		 5vkqA-5z5cA:
undetectable
5vkqB-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 7 THR A 215
HIS A 225
PRO A 210
ILE A 227
 MLY  A 221 ( 3.1A)
MLY  A 224 ( 4.8A)
None
None
 1.20A 5vkqC-5z5cA:
undetectable
5vkqD-5z5cA:
undetectable		 5vkqC-5z5cA:
undetectable
5vkqD-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		3 / 3 LYS A 205
PRO A 207
LYS A 241
 MLY  A 204 ( 3.3A)
None
MLY  A 240 ( 3.0A)
 1.31A 5y9yA-5z5cA:
undetectable		 5y9yA-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 12 THR A 188
GLY A 186
THR A  53
LEU A  54
PHE A  81
 PLP  A 401 (-3.6A)
PLP  A 401 (-3.5A)
None
MLY  A  55 ( 4.2A)
None
 1.06A 5ybbA-5z5cA:
undetectable		 5ybbA-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5z5c CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 12 LEU A 216
GLY A 186
GLY A 184
GLY A 229
ASN A 212
 None
PLP  A 401 (-3.5A)
PLP  A 401 (-3.6A)
PLP  A 401 (-3.6A)
None
 1.06A 6ce2B-5z5cA:
undetectable		 6ce2B-5z5cA:
20.00