SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5z5k DRAXIN
NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 7 ARG B 282
ILE A 387
TYR A 398
GLY A 396
 None
 0.95A 11gsA-5z5kB:
undetectable		 11gsA-5z5kB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_B_DVAB6_0
(GRAMICIDIN A)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 4 VAL A 190
TRP A 173
ALA A 196
VAL A 191
 None
 1.40A 1gmkA-5z5kA:
undetectable
1gmkB-5z5kA:
undetectable		 1gmkA-5z5kA:
undetectable
1gmkB-5z5kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD6_0
(GRAMICIDIN A)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 4 VAL A 190
TRP A 173
ALA A 196
VAL A 191
 None
 1.36A 1gmkC-5z5kA:
undetectable
1gmkD-5z5kA:
undetectable		 1gmkC-5z5kA:
undetectable
1gmkD-5z5kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		5 / 12 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.24A 1q23B-5z5kA:
undetectable		 1q23B-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		5 / 12 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.22A 1q23C-5z5kA:
undetectable		 1q23C-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		5 / 10 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.22A 1q23E-5z5kA:
undetectable		 1q23E-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		5 / 11 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.17A 1q23F-5z5kA:
undetectable		 1q23F-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		5 / 12 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.19A 1q23H-5z5kA:
undetectable
1q23I-5z5kA:
undetectable		 1q23H-5z5kA:
15.46
1q23I-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		5 / 11 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.21A 1q23I-5z5kA:
undetectable		 1q23I-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		5 / 10 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.20A 1q23K-5z5kA:
undetectable		 1q23K-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		5 / 11 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.29A 1q23L-5z5kA:
undetectable		 1q23L-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5z5k DRAXIN
NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 8 ARG B 282
ILE A 387
TYR A 398
GLY A 396
 None
 0.95A 2gssA-5z5kB:
undetectable		 2gssA-5z5kB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5z5k DRAXIN
NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 8 ARG B 282
ILE A 387
TYR A 398
GLY A 396
 None
 0.94A 2gssB-5z5kB:
undetectable		 2gssB-5z5kB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 8 LEU A  81
PRO A  46
SER A 129
VAL A 134
 None
 1.20A 2qd2A-5z5kA:
undetectable		 2qd2A-5z5kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 5z5k DRAXIN
NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 8 ARG B 282
ILE A 387
TYR A 398
GLY A 396
 None
 0.95A 3n9jA-5z5kB:
undetectable		 3n9jA-5z5kB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 5 LEU A 296
LEU A 295
LEU A 282
SER A 284
 None
 0.95A 3vhuA-5z5kA:
undetectable		 3vhuA-5z5kA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5z5k NETRIN RECEPTOR DCC
DRAXIN
(Rattus
norvegicus;
Rattus
norvegicus) 		3 / 3 ASP B 300
ARG B 308
ASP A  77
 None
 0.82A 4fp9D-5z5kB:
undetectable		 4fp9D-5z5kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 7 LEU A  81
PRO A  46
SER A 129
VAL A 134
 None
 1.17A 4klrA-5z5kA:
undetectable		 4klrA-5z5kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		3 / 3 PRO A 193
LEU A 192
GLN A 244
 None
 0.71A 4pevB-5z5kA:
undetectable		 4pevB-5z5kA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 8 ILE A 199
MET A 153
ALA A 151
VAL A 157
 None
 0.69A 4rjdA-5z5kA:
undetectable		 4rjdA-5z5kA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5z5k NETRIN RECEPTOR DCC
DRAXIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 7 LYS A  75
GLY A 368
ASN A 367
HIS B 269
 None
 1.07A 5a5zC-5z5kA:
undetectable		 5a5zC-5z5kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5z5k NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 5 TYR A 115
VAL A 134
ASP A  48
ALA A  49
 None
 1.10A 5otrA-5z5kA:
undetectable		 5otrA-5z5kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5z5k DRAXIN
NETRIN RECEPTOR DCC
(Rattus
norvegicus) 		4 / 5 VAL A 391
HIS B 284
LEU A 415
ASP B 280
 None
 1.23A 5vcvA-5z5kA:
undetectable		 5vcvA-5z5kA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5z5k NETRIN RECEPTOR DCC
DRAXIN
(Rattus
norvegicus;
Rattus
norvegicus) 		3 / 3 ASP B 300
ARG B 308
ASP A  77
 None
 0.86A 5zvgA-5z5kB:
undetectable		 5zvgA-5z5kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5z5k NETRIN RECEPTOR DCC
DRAXIN
(Rattus
norvegicus;
Rattus
norvegicus) 		3 / 3 ASP B 300
ARG B 308
ASP A  77
 None
 0.82A 5zvgB-5z5kB:
undetectable		 5zvgB-5z5kB:
undetectable