SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A 314
VAL A  25
VAL A 348
GLY A 350
LEU A 312
 None
 1.23A 1fkpA-5z67A:
undetectable		 1fkpA-5z67A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		5 / 9 LEU A 314
VAL A  25
VAL A 348
GLY A 350
LEU A 312
 None
 1.26A 1vrtA-5z67A:
2.9		 1vrtA-5z67A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		5 / 10 LEU A 314
VAL A  25
VAL A 348
GLY A 350
LEU A 312
 None
 1.33A 2hndA-5z67A:
2.7		 2hndA-5z67A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		5 / 10 LEU A 314
VAL A  25
VAL A 348
GLY A 350
LEU A 312
 None
 1.32A 2hnyA-5z67A:
2.9		 2hnyA-5z67A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		3 / 3 ASN A  13
ASN A  38
ARG A  53
 None
 0.88A 2rlcA-5z67A:
undetectable		 2rlcA-5z67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		4 / 6 ILE A 223
LEU A 272
LEU A 225
ASP A 268
 None
 1.06A 2rlfA-5z67A:
undetectable
2rlfD-5z67A:
undetectable		 2rlfA-5z67A:
19.74
2rlfD-5z67A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		4 / 4 GLU A 304
GLY A 307
THR A 306
GLU A 308
 None
 1.06A 3e9xA-5z67A:
undetectable		 3e9xA-5z67A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_A_CHDA2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		5 / 9 LEU A 225
ARG A 266
ARG A 134
SER A 278
GLY A 129
 None
 1.40A 3hcpA-5z67A:
0.1		 3hcpA-5z67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		4 / 5 LEU A 114
SER A  47
ARG A  44
PRO A 310
 None
 1.37A 3onnA-5z67A:
undetectable		 3onnA-5z67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		6 / 9 LEU A 238
ALA A 191
GLY A 263
VAL A 262
VAL A 230
ILE A 239
 None
 1.27A 3oxvA-5z67A:
undetectable		 3oxvA-5z67A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		5 / 10 LEU A 238
ALA A 191
GLY A 263
VAL A 262
VAL A 230
 None
 1.03A 3oxwC-5z67A:
undetectable		 3oxwC-5z67A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		6 / 10 LEU A 238
ALA A 191
GLY A 263
VAL A 262
VAL A 230
ILE A 239
 None
 1.11A 3oxwD-5z67A:
undetectable		 3oxwD-5z67A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		4 / 5 TYR A 148
ASN A 199
TYR A 200
ILE A 144
 None
 1.35A 4o0oA-5z67A:
undetectable		 4o0oA-5z67A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		4 / 5 LEU A 238
ALA A 228
ASN A 226
ILE A 194
 None
 0.83A 4y03B-5z67A:
undetectable		 4y03B-5z67A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		5 / 12 GLY A  72
ARG A  71
ASN A  26
PHE A  21
LEU A   3
 None
 1.23A 5fhzA-5z67A:
undetectable		 5fhzA-5z67A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 137
LEU A 204
MET A 208
ILE A 125
ILE A 271
 None
 1.12A 5itzB-5z67A:
undetectable		 5itzB-5z67A:
11.58