SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5z6o PROTEASE
(Penicillium
cyclopium) 		4 / 7 GLY A 200
ALA A 185
THR A 271
SER A 193
 None
 0.89A 1c9sT-5z6oA:
undetectable
1c9sU-5z6oA:
undetectable		 1c9sT-5z6oA:
undetectable
1c9sU-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5z6o PROTEASE
(Penicillium
cyclopium) 		4 / 7 GLY A 200
ALA A 185
THR A 271
SER A 193
 None
 0.90A 1gtfL-5z6oA:
undetectable
1gtfM-5z6oA:
undetectable		 1gtfL-5z6oA:
undetectable
1gtfM-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 12 GLY A 209
GLY A 226
ILE A 184
SER A 187
TYR A 206
 None
PMS  A 302 (-3.6A)
None
None
None
 1.05A 1ri4A-5z6oA:
2.0		 1ri4A-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 12 PHE A  52
PRO A 232
ALA A 230
ALA A  56
ALA A  96
 None
 1.26A 2x2nA-5z6oA:
undetectable		 2x2nA-5z6oA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 12 PHE A  52
PRO A 232
ALA A 230
ALA A  56
ALA A  96
 None
 1.30A 2x2nB-5z6oA:
undetectable		 2x2nB-5z6oA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 12 GLY A 236
VAL A 203
SER A 160
ALA A 162
ALA A 163
 None
None
None
PMS  A 302 (-3.6A)
None
 1.06A 3keeC-5z6oA:
undetectable		 3keeC-5z6oA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5z6o PROTEASE
(Penicillium
cyclopium) 		3 / 3 SER A 201
ASP A 169
ASN A 172
 None
 0.94A 3lsfB-5z6oA:
undetectable
3lsfE-5z6oA:
undetectable		 3lsfB-5z6oA:
undetectable
3lsfE-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5z6o PROTEASE
(Penicillium
cyclopium) 		3 / 3 ASP A 169
ASN A 172
SER A 201
 None
 0.97A 3lsfB-5z6oA:
undetectable
3lsfE-5z6oA:
undetectable		 3lsfB-5z6oA:
undetectable
3lsfE-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5z6o PROTEASE
(Penicillium
cyclopium) 		4 / 4 SER A  10
ASP A  51
ASP A  46
ALA A 214
 None
 1.43A 3uj6A-5z6oA:
2.4		 3uj6A-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 12 GLY A  87
GLY A  83
SER A  17
ASP A 259
LEU A 241
 None
 0.83A 4fp9D-5z6oA:
2.1		 4fp9D-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 12 GLY A  87
GLY A  83
SER A  17
ASP A 259
LEU A 241
 None
 0.80A 4fzvA-5z6oA:
3.0		 4fzvA-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5z6o PROTEASE
(Penicillium
cyclopium) 		4 / 6 SER A 228
GLY A 101
ASP A 103
GLY A 106
 PMS  A 302 (-1.5A)
None
None
None
 1.00A 4koeA-5z6oA:
undetectable
4koeB-5z6oA:
undetectable
4koeC-5z6oA:
2.2		 4koeA-5z6oA:
10.25
4koeB-5z6oA:
10.25
4koeC-5z6oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 9 ALA A 162
ALA A 231
GLY A 139
GLY A 138
ASP A  42
 PMS  A 302 (-3.6A)
None
None
PMS  A 302 (-3.7A)
PMS  A 302 ( 3.9A)
 1.19A 4qwuK-5z6oA:
undetectable
4qwuL-5z6oA:
undetectable		 4qwuK-5z6oA:
19.21
4qwuL-5z6oA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 12 GLY A  12
TYR A 206
SER A 187
SER A   8
GLN A   5
 None
 1.33A 4xueB-5z6oA:
2.3		 4xueB-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5z6o PROTEASE
(Penicillium
cyclopium) 		4 / 6 GLY A 101
ASP A 103
GLY A 106
SER A 228
 None
None
None
PMS  A 302 (-1.5A)
 1.02A 4z53A-5z6oA:
undetectable
4z53B-5z6oA:
undetectable		 4z53A-5z6oA:
7.24
4z53B-5z6oA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5z6o PROTEASE
(Penicillium
cyclopium) 		4 / 8 SER A 193
GLY A 200
ALA A 185
THR A 271
 None
 0.89A 5eezL-5z6oA:
undetectable
5eezV-5z6oA:
undetectable		 5eezL-5z6oA:
undetectable
5eezV-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5z6o PROTEASE
(Penicillium
cyclopium) 		4 / 8 SER A 193
GLY A 200
ALA A 185
THR A 271
 None
 0.89A 5ef1L-5z6oA:
undetectable
5ef1V-5z6oA:
undetectable		 5ef1L-5z6oA:
undetectable
5ef1V-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5z6o PROTEASE
(Penicillium
cyclopium) 		4 / 8 SER A 193
GLY A 200
ALA A 185
THR A 271
 None
 0.89A 5ef2L-5z6oA:
undetectable
5ef2V-5z6oA:
undetectable		 5ef2L-5z6oA:
undetectable
5ef2V-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5z6o PROTEASE
(Penicillium
cyclopium) 		5 / 12 SER A 160
VAL A 234
ARG A 255
ILE A 256
ASP A 259
 None
 1.30A 6bxnA-5z6oA:
2.4		 6bxnA-5z6oA:
undetectable