SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5z72 CCPC
(Bacillus
velezensis) 		5 / 12 GLY A 148
THR A 262
SER A 129
ALA A  98
ILE A 218
 None
None
FLC  A 303 ( 2.1A)
FLC  A 303 (-3.1A)
FLC  A 303 ( 4.5A)
 0.98A 1gtnL-5z72A:
undetectable
1gtnV-5z72A:
undetectable		 1gtnL-5z72A:
undetectable
1gtnV-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5z72 CCPC
(Bacillus
velezensis) 		3 / 3 TRP A 200
PHE A 205
TRP A 201
 None
 0.95A 1r15C-5z72A:
undetectable		 1r15C-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5z72 CCPC
(Bacillus
velezensis) 		3 / 3 TRP A 200
PHE A 205
TRP A 201
 None
 0.93A 1r15F-5z72A:
undetectable		 1r15F-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5z72 CCPC
(Bacillus
velezensis) 		3 / 3 TRP A 200
PHE A 205
TRP A 201
 None
 0.93A 1r15G-5z72A:
undetectable		 1r15G-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5z72 CCPC
(Bacillus
velezensis) 		3 / 3 TRP A 200
PHE A 205
TRP A 201
 None
 0.93A 1r15H-5z72A:
undetectable		 1r15H-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5z72 CCPC
(Bacillus
velezensis) 		5 / 12 ILE A 218
GLY A 148
THR A 262
SER A 129
ALA A  98
 FLC  A 303 ( 4.5A)
None
None
FLC  A 303 ( 2.1A)
FLC  A 303 (-3.1A)
 0.95A 1utdL-5z72A:
undetectable
1utdM-5z72A:
undetectable		 1utdL-5z72A:
undetectable
1utdM-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5z72 CCPC
(Bacillus
velezensis) 		5 / 12 ILE A 218
GLY A 148
THR A 262
SER A 129
ALA A  98
 FLC  A 303 ( 4.5A)
None
None
FLC  A 303 ( 2.1A)
FLC  A 303 (-3.1A)
 0.95A 1utdO-5z72A:
undetectable
1utdP-5z72A:
undetectable		 1utdO-5z72A:
undetectable
1utdP-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5z72 CCPC
(Bacillus
velezensis) 		5 / 11 ILE A 218
GLY A 148
THR A 262
SER A 129
ALA A  98
 FLC  A 303 ( 4.5A)
None
None
FLC  A 303 ( 2.1A)
FLC  A 303 (-3.1A)
 0.94A 1utdP-5z72A:
undetectable
1utdQ-5z72A:
undetectable		 1utdP-5z72A:
undetectable
1utdQ-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5z72 CCPC
(Bacillus
velezensis) 		5 / 9 LEU A 159
VAL A 109
ILE A 143
LEU A  95
PHE A 279
 None
 1.34A 3fl9D-5z72A:
undetectable		 3fl9D-5z72A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5z72 CCPC
(Bacillus
velezensis) 		3 / 4 ARG A 155
GLY A 154
GLU A 268
 None
 0.44A 4z2dB-5z72A:
undetectable
4z2dC-5z72A:
undetectable		 4z2dB-5z72A:
11.31
4z2dC-5z72A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5z72 CCPC
(Bacillus
velezensis) 		4 / 6 ASP A 157
ARG A 155
GLY A 154
GLU A 268
 None
 0.81A 5cdqA-5z72A:
undetectable
5cdqC-5z72A:
undetectable
5cdqD-5z72A:
undetectable		 5cdqA-5z72A:
8.94
5cdqC-5z72A:
8.94
5cdqD-5z72A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5z72 CCPC
(Bacillus
velezensis) 		4 / 6 ASP A 157
ARG A 155
GLY A 266
GLU A 268
 None
 0.86A 5cdqA-5z72A:
undetectable
5cdqC-5z72A:
undetectable
5cdqD-5z72A:
undetectable		 5cdqA-5z72A:
8.94
5cdqC-5z72A:
8.94
5cdqD-5z72A:
16.32