SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z7h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		3 / 3 ASP A 198
ASN A 199
THR A 175
 None
 0.67A 2pymB-5z7hA:
undetectable		 2pymB-5z7hA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		5 / 10 LEU A 278
LEU A 157
LEU A 105
VAL A 109
PHE A 275
 None
 0.77A 2w9gA-5z7hA:
undetectable		 2w9gA-5z7hA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		5 / 10 LEU A 278
LEU A 157
LEU A 105
VAL A 109
PHE A 275
 None
 0.90A 2w9hA-5z7hA:
2.1		 2w9hA-5z7hA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		5 / 11 LEU A 278
LEU A 157
LEU A 105
VAL A 109
PHE A 275
 None
 0.79A 3frbX-5z7hA:
undetectable		 3frbX-5z7hA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		4 / 7 ILE A 189
GLU A 181
TYR A 204
VAL A 174
 None
 1.05A 4a97A-5z7hA:
undetectable		 4a97A-5z7hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		4 / 7 ILE A 189
GLU A 181
TYR A 204
VAL A 174
 None
 1.08A 4a97D-5z7hA:
undetectable		 4a97D-5z7hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		4 / 7 ILE A 189
GLU A 181
TYR A 204
VAL A 174
 None
 1.00A 4a97H-5z7hA:
undetectable		 4a97H-5z7hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		4 / 5 TYR A 196
ILE A 192
ASN A 199
ILE A 228
 None
 0.96A 4jtpA-5z7hA:
undetectable		 4jtpA-5z7hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		5 / 12 LEU A 177
GLY A 225
SER A 238
GLN A 241
ILE A 221
 None
 1.23A 6bxmA-5z7hA:
3.4		 6bxmA-5z7hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		5 / 12 LEU A 177
GLY A 225
SER A 238
GLN A 241
ILE A 221
 None
 1.17A 6bxnB-5z7hA:
3.2		 6bxnB-5z7hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		4 / 8 ASP A 185
ILE A 187
ARG A 256
TYR A 204
 None
None
FLC  A 301 (-3.6A)
None
 1.25A 6hisA-5z7hA:
undetectable
6hisB-5z7hA:
undetectable		 6hisA-5z7hA:
22.99
6hisB-5z7hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		4 / 8 ASP A 185
ILE A 187
ARG A 256
TYR A 204
 None
None
FLC  A 301 (-3.6A)
None
 1.25A 6hisB-5z7hA:
undetectable
6hisC-5z7hA:
undetectable		 6hisB-5z7hA:
22.99
6hisC-5z7hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		4 / 8 ASP A 185
ILE A 187
ARG A 256
TYR A 204
 None
None
FLC  A 301 (-3.6A)
None
 1.25A 6hisD-5z7hA:
undetectable
6hisE-5z7hA:
undetectable		 6hisD-5z7hA:
22.99
6hisE-5z7hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Staphylococcus
aureus) 		4 / 7 ARG A 256
HIS A 162
ASP A 185
GLU A 130
 FLC  A 301 (-3.6A)
None
None
FLC  A 301 (-3.6A)
 1.29A 6mn4F-5z7hA:
undetectable		 6mn4F-5z7hA:
undetectable