SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 10 THR A  32
PHE A  62
LEU A  54
VAL A 100
VAL A  17
None
1.44A 1q23K-5z7rA:
undetectable
1q23K-5z7rA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 9 LEU A  33
VAL A  63
ALA A 108
MET A 117
PHE A  90
None
1.00A 1tbfA-5z7rA:
undetectable
1tbfA-5z7rA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 12 ILE A  43
MET A  36
ARG A  91
LEU A  54
ILE A 115
None
1.43A 1y0xX-5z7rA:
undetectable
1y0xX-5z7rA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 12 GLY A 111
GLU A 134
THR A 140
PHE A  90
GLY A  86
None
0.93A 3ag4A-5z7rA:
undetectable
3ag4B-5z7rA:
undetectable
3ag4T-5z7rA:
undetectable
3ag4A-5z7rA:
undetectable
3ag4B-5z7rA:
undetectable
3ag4T-5z7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
3 / 3 MET A   1
VAL A   6
GLU A  42
None
0.58A 3c6gA-5z7rA:
undetectable
3c6gA-5z7rA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 12 ILE A 115
GLY A 112
GLY A 111
ALA A  27
VAL A  63
None
0.92A 3jb2A-5z7rA:
undetectable
3jb2A-5z7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 12 LEU A 188
GLU A  59
GLY A  58
ALA A  57
ASN A  20
None
1.33A 4pclB-5z7rA:
undetectable
4pclB-5z7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 12 GLY A  65
MET A  36
GLY A  56
PHE A 107
ILE A  19
None
1.18A 5vooD-5z7rA:
2.6
5vooD-5z7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 12 ALA A 116
PHE A  90
GLY A  65
ALA A  66
LEU A  33
None
1.06A 5x23A-5z7rA:
undetectable
5x23A-5z7rA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
4 / 7 VAL A 100
LEU A  25
PHE A  90
LEU A  28
None
0.93A 6aycA-5z7rA:
undetectable
6aycA-5z7rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
3 / 3 PRO A 185
SER A 126
SER A 125
None
0.67A 6bpyA-5z7rA:
undetectable
6bpyA-5z7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum)
5 / 12 VAL A   6
VAL A  63
GLY A  65
PHE A  90
VAL A  89
None
1.03A 6bqgA-5z7rA:
undetectable
6bqgA-5z7rA:
24.10