SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 10 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.06A 1pxxA-5z96A:
0.9		 1pxxA-5z96A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 12 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.08A 1pxxC-5z96A:
2.4		 1pxxC-5z96A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		4 / 7 ALA A 210
LEU A 208
SER A 205
VAL A 718
 None
 0.71A 3ozkB-5z96A:
undetectable		 3ozkB-5z96A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 12 GLY A  43
ALA A  77
ASN A  82
VAL A  48
LEU A  37
 None
 1.03A 4dc3A-5z96A:
undetectable		 4dc3A-5z96A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		4 / 5 LEU A 527
ILE A 607
ALA A 529
PHE A 530
 LPP  A 802 (-4.7A)
None
None
None
 0.87A 4dc3B-5z96A:
undetectable		 4dc3B-5z96A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		4 / 5 THR A 563
GLN A 569
GLU A 566
THR A 567
 None
LPP  A 802 (-3.2A)
None
None
 1.34A 4eahA-5z96A:
0.9
4eahE-5z96A:
0.9
4eahG-5z96A:
undetectable		 4eahA-5z96A:
undetectable
4eahE-5z96A:
undetectable
4eahG-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		3 / 3 TYR A 706
PHE A 221
ARG A 288
 None
 1.21A 4g19D-5z96A:
undetectable		 4g19D-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		3 / 3 TYR A 706
PHE A 300
ARG A 288
 None
 1.07A 4g19D-5z96A:
undetectable		 4g19D-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		4 / 8 ASN A 485
ALA A 484
LEU A 380
TYR A 373
 None
 1.22A 4ijiF-5z96A:
2.6		 4ijiF-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		3 / 3 GLU A 138
ARG A 105
HIS A 102
 None
 0.56A 4kf9A-5z96A:
undetectable		 4kf9A-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 12 VAL A  96
LEU A  83
LEU A  90
ALA A 103
LEU A 100
 None
 1.30A 4m11C-5z96A:
2.2		 4m11C-5z96A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 12 TRP A 422
GLY A 651
THR A 652
ASN A 658
GLU A 648
 None
 1.09A 4zvmA-5z96A:
undetectable
4zvmB-5z96A:
undetectable		 4zvmA-5z96A:
17.17
4zvmB-5z96A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 12 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.11A 5ikqA-5z96A:
1.7		 5ikqA-5z96A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 12 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.12A 5ikqB-5z96A:
undetectable		 5ikqB-5z96A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 12 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.06A 5iktA-5z96A:
1.7		 5iktA-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		5 / 12 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.08A 5iktB-5z96A:
undetectable		 5iktB-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		4 / 5 LEU A 513
LEU A 517
MET A 437
GLN A 506
 LPP  A 802 (-4.3A)
None
None
None
 1.38A 5uc3A-5z96A:
undetectable		 5uc3A-5z96A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4
(Mus
musculus) 		4 / 4 GLY A 110
LEU A  83
VAL A 108
GLU A  81
 None
 1.48A 5yw0A-5z96A:
undetectable		 5yw0A-5z96A:
undetectable