SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 327
ALA A 204
LEU A 188
VAL A 185
ILE A 164
 None
 1.29A 1claA-5z9aA:
undetectable		 1claA-5z9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 4 ARG A  47
ALA A 139
ALA A 336
GLU A 332
 None
 1.22A 1e7bB-5z9aA:
undetectable		 1e7bB-5z9aA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A   6
ILE A 337
GLU A 332
ILE A 206
ALA A 327
 None
 1.16A 1jtxA-5z9aA:
undetectable		 1jtxA-5z9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 327
ILE A 330
ILE A 206
VAL A 208
ALA A 287
 None
 1.02A 1uduB-5z9aA:
undetectable		 1uduB-5z9aA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A  81
VAL A  27
ILE A 150
ILE A 285
 None
 0.81A 1uwhA-5z9aA:
undetectable		 1uwhA-5z9aA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A  14
THR A  13
ALA A  25
SER A   2
GLY A   3
 None
 1.07A 2f162-5z9aA:
undetectable		 2f162-5z9aA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A  14
THR A  13
ALA A  25
SER A   2
GLY A   3
 None
 1.08A 2f16N-5z9aA:
undetectable		 2f16N-5z9aA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 209
GLN A 151
GLY A 147
LEU A  34
 None
 1.10A 3bjwE-5z9aA:
undetectable		 3bjwE-5z9aA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  14
THR A  13
ALA A  25
SER A   2
GLY A   3
 None
 1.07A 3mg02-5z9aA:
undetectable
3mg0V-5z9aA:
undetectable		 3mg02-5z9aA:
17.35
3mg0V-5z9aA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A  14
THR A  13
ALA A  25
SER A   2
GLY A   3
 None
 1.07A 3mg0N-5z9aA:
undetectable		 3mg0N-5z9aA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 155
GLU A 243
ILE A 244
ALA A 246
ILE A 285
 None
 1.01A 3ndiA-5z9aA:
undetectable		 3ndiA-5z9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  25
LEU A  23
THR A  14
VAL A  12
 None
 0.63A 3ozkB-5z9aA:
undetectable		 3ozkB-5z9aA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  25
LEU A  23
THR A  14
VAL A  12
 None
 0.64A 4ik7B-5z9aA:
undetectable		 4ik7B-5z9aA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A  27
LEU A  83
CYH A  30
LEU A  36
 None
 1.18A 5hrqB-5z9aA:
undetectable
5hrqI-5z9aA:
undetectable
5hrqJ-5z9aA:
undetectable		 5hrqB-5z9aA:
undetectable
5hrqI-5z9aA:
undetectable
5hrqJ-5z9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  14
THR A  13
ALA A  25
SER A   2
GLY A   3
 None
 0.88A 5lf7V-5z9aA:
undetectable
5lf7b-5z9aA:
undetectable		 5lf7V-5z9aA:
undetectable
5lf7b-5z9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  14
THR A  13
ALA A  25
SER A   2
GLY A   3
 None
 0.89A 5lf7H-5z9aA:
undetectable
5lf7N-5z9aA:
undetectable		 5lf7H-5z9aA:
undetectable
5lf7N-5z9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A  37
ARG A  39
ASP A  40
LYS A 143
 None
 1.20A 6dwdA-5z9aA:
undetectable		 6dwdA-5z9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5z9a CHORISMATE SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 206
LEU A 289
ARG A 326
THR A 131
 None
 1.02A 6nmfN-5z9aA:
undetectable
6nmfW-5z9aA:
undetectable		 6nmfN-5z9aA:
undetectable
6nmfW-5z9aA:
undetectable