SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 4 VAL A 160
TRP A 422
TRP A 157
None
1.23A 1gmkA-5z9sA:
undetectable
1gmkB-5z9sA:
undetectable
1gmkA-5z9sA:
undetectable
1gmkB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 4 VAL A 160
TRP A 422
TRP A 157
None
1.14A 1gmkC-5z9sA:
undetectable
1gmkD-5z9sA:
undetectable
1gmkC-5z9sA:
undetectable
1gmkD-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 GLN A 416
ASP A 414
LEU A 469
SER A 426
None
1.21A 1ig3A-5z9sA:
undetectable
1ig3B-5z9sA:
undetectable
1ig3A-5z9sA:
15.97
1ig3B-5z9sA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLN A 428
HIS A  68
ILE A 279
ASP A 281
HIS A 203
None
BGC  A 801 (-4.0A)
None
BGC  A 801 (-2.8A)
BGC  A 801 (-3.9A)
1.18A 1kxhA-5z9sA:
undetectable
1kxhA-5z9sA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 HIS A 142
GLY A 140
GLU A 134
ARG A 130
PRO A 193
None
1.49A 1mjqG-5z9sA:
undetectable
1mjqH-5z9sA:
undetectable
1mjqG-5z9sA:
undetectable
1mjqH-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ILE A 197
GLY A 140
VAL A 136
ALA A  78
GLY A  94
None
1.16A 1nbiA-5z9sA:
undetectable
1nbiA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ILE A 197
GLY A 140
VAL A 136
ALA A  78
GLY A  94
None
1.15A 1nbiB-5z9sA:
undetectable
1nbiB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 ALA A 302
VAL A 306
ALA A 303
HIS A 300
None
0.91A 1q23A-5z9sA:
undetectable
1q23A-5z9sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 ALA A 302
VAL A 306
ALA A 303
HIS A 300
None
0.92A 1q23F-5z9sA:
undetectable
1q23F-5z9sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 ALA A 302
VAL A 306
ALA A 303
HIS A 300
None
0.91A 1q23K-5z9sA:
undetectable
1q23K-5z9sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 VAL A 742
ALA A 743
HIS A 691
None
0.72A 1q23J-5z9sA:
undetectable
1q23J-5z9sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 GLU A 725
ASN A 636
TRP A 229
None
1.00A 1r15C-5z9sA:
undetectable
1r15C-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 GLU A 725
ASN A 636
TRP A 229
None
1.00A 1r15D-5z9sA:
undetectable
1r15D-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 GLU A 725
ASN A 636
TRP A 229
None
0.99A 1r15E-5z9sA:
undetectable
1r15E-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 GLU A 725
ASN A 636
TRP A 229
None
1.04A 1r15F-5z9sA:
undetectable
1r15F-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLN A 565
THR A 155
ALA A 152
SER A 561
LEU A 389
None
1.09A 1rjdA-5z9sA:
undetectable
1rjdA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLN A 565
THR A 155
ALA A 152
SER A 561
LEU A 389
None
1.10A 1rjdB-5z9sA:
undetectable
1rjdB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 THR A 144
GLY A 100
SER A 102
HIS A  99
ILE A 377
None
1.17A 2b25B-5z9sA:
undetectable
2b25B-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 GLY A 588
THR A 557
ILE A 592
GLY A 590
None
0.88A 2jklC-5z9sA:
undetectable
2jklC-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 5 PRO A 764
ALA A 788
ASP A 714
ASP A 723
None
1.16A 2nyuB-5z9sA:
undetectable
2nyuB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 ALA A 654
VAL A 566
PHE A 624
THR A 155
None
1.42A 2pkkA-5z9sA:
3.1
2pkkA-5z9sA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 LYS A 295
ALA A 301
PHE A 319
GLY A 322
None
1.31A 2rddA-5z9sA:
undetectable
2rddA-5z9sA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 ILE A 279
ASP A  95
LEU A  67
GLY A  94
None
0.85A 2tsrA-5z9sA:
undetectable
2tsrA-5z9sA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 6 THR A 244
GLN A 183
LEU A 351
LEU A 192
None
0.96A 3bgdA-5z9sA:
undetectable
3bgdA-5z9sA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ILE A  93
ILE A 197
SER A 137
LEU A 351
ILE A  92
None
1.05A 3cd2A-5z9sA:
undetectable
3cd2A-5z9sA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 5 PRO A 410
VAL A 466
THR A 423
GLY A 420
None
1.20A 3elzB-5z9sA:
undetectable
3elzB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 ALA A 464
ASN A 504
VAL A 515
ALA A 505
ILE A 511
None
1.15A 3fl9F-5z9sA:
undetectable
3fl9F-5z9sA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 LEU A 541
ALA A 513
VAL A 408
PRO A 410
None
1.14A 3gv1B-5z9sA:
undetectable
3gv1B-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 LEU A 379
GLY A 602
VAL A 444
LEU A 613
ILE A 609
None
1.36A 3h52A-5z9sA:
undetectable
3h52A-5z9sA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 LEU A 170
ARG A 731
PRO A 596
GLY A 618
None
1.04A 3hcnA-5z9sA:
2.5
3hcnA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 LEU A 170
ARG A 731
PRO A 596
GLY A 618
None
0.89A 3hcrB-5z9sA:
2.3
3hcrB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ILE A 386
VAL A 444
ILE A 405
VAL A 512
VAL A 558
None
0.95A 3iw1A-5z9sA:
undetectable
3iw1A-5z9sA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLY A 516
ASP A 414
GLY A 420
SER A 562
ASN A 597
None
1.29A 3k13A-5z9sA:
5.7
3k13A-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLY A 516
ASP A 414
GLY A 420
SER A 562
ASN A 597
None
1.27A 3k13B-5z9sA:
5.8
3k13B-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLY A 516
ASP A 414
GLY A 420
SER A 562
ASN A 597
None
1.28A 3k13C-5z9sA:
5.7
3k13C-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 VAL A 732
LEU A 734
PHE A 744
ILE A 694
GLY A 772
None
1.26A 3kk6B-5z9sA:
undetectable
3kk6B-5z9sA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 9 GLY A 115
ILE A  98
PHE A 234
PHE A 164
GLY A 165
None
1.40A 3ko0A-5z9sA:
0.3
3ko0C-5z9sA:
0.5
3ko0A-5z9sA:
17.48
3ko0C-5z9sA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 ASP A 714
GLU A 766
GLY A 765
None
0.57A 3w9tA-5z9sA:
undetectable
3w9tA-5z9sA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA502_1
(CHITINASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 TRP A 594
GLY A 165
TRP A 120
ALA A 117
None
1.32A 3wqvA-5z9sA:
1.0
3wqvA-5z9sA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 5 TRP A 594
GLY A 165
TRP A 120
ALA A 117
None
1.34A 3wqwA-5z9sA:
1.1
3wqwA-5z9sA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLY A 463
ILE A 498
GLN A 537
VAL A 408
ILE A 511
None
0.93A 4ax8A-5z9sA:
undetectable
4ax8A-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 LEU A 661
ILE A 592
GLY A 660
PHE A 655
None
1.14A 4dc3A-5z9sA:
4.5
4dc3A-5z9sA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 LEU A 769
ILE A 712
GLY A 713
THR A 786
PHE A 684
None
0.91A 4fakA-5z9sA:
undetectable
4fakA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 VAL A 566
PRO A 625
GLU A 166
THR A 163
GLY A 165
None
1.22A 4hvcA-5z9sA:
undetectable
4hvcA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 VAL A 566
PRO A 625
GLU A 166
THR A 163
GLY A 165
None
1.23A 4hvcB-5z9sA:
undetectable
4hvcB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 ILE A 279
ASP A  95
LEU A  67
GLY A  94
None
0.83A 4iqqC-5z9sA:
undetectable
4iqqC-5z9sA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 PRO A 147
VAL A 179
MET A 178
ALA A 177
None
0.85A 4lb2A-5z9sA:
undetectable
4lb2A-5z9sA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 VAL A 179
MET A 178
ALA A 175
PHE A 164
None
1.15A 4lb2A-5z9sA:
undetectable
4lb2A-5z9sA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 SER A 591
ASP A 392
ILE A 386
GLY A 618
ARG A 702
None
1.23A 4obwC-5z9sA:
undetectable
4obwC-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 11 GLY A 602
GLY A 603
ILE A 386
GLY A 420
ILE A 560
None
1.01A 4qoiA-5z9sA:
undetectable
4qoiB-5z9sA:
4.0
4qoiA-5z9sA:
18.75
4qoiB-5z9sA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLY A 243
GLY A 276
ASN A 275
ALA A 196
ALA A 186
None
1.07A 4uckB-5z9sA:
undetectable
4uckB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 LEU A 411
ASN A 597
ALA A 595
VAL A 558
ILE A 386
None
1.16A 4x1yB-5z9sA:
undetectable
4x1yB-5z9sA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 GLY A 158
THR A 155
LEU A 531
SER A 562
LEU A 114
None
1.31A 4yb6A-5z9sA:
undetectable
4yb6E-5z9sA:
undetectable
4yb6A-5z9sA:
undetectable
4yb6E-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 GLY A 158
THR A 155
LEU A 531
SER A 562
LEU A 114
None
1.29A 4yb6C-5z9sA:
undetectable
4yb6F-5z9sA:
undetectable
4yb6C-5z9sA:
undetectable
4yb6F-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 LEU A 531
SER A 562
LEU A 114
GLY A 158
THR A 155
None
1.29A 4yb6A-5z9sA:
undetectable
4yb6D-5z9sA:
undetectable
4yb6A-5z9sA:
undetectable
4yb6D-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 LEU A 531
SER A 562
LEU A 114
GLY A 158
THR A 155
None
1.33A 4yb6D-5z9sA:
undetectable
4yb6E-5z9sA:
undetectable
4yb6D-5z9sA:
undetectable
4yb6E-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 LEU A 388
SER A 662
GLY A 660
ILE A 609
GLY A 618
None
1.04A 4yvgA-5z9sA:
undetectable
4yvgA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 VAL A 705
ALA A 703
PHE A 666
None
0.87A 4z4iA-5z9sA:
2.2
4z4iA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 LEU A 263
LEU A 247
GLY A 248
GLU A 250
None
1.11A 5hhjA-5z9sA:
undetectable
5hhjA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ILE A 771
LEU A 696
VAL A 732
PHE A 744
GLN A 730
None
1.20A 5im2A-5z9sA:
undetectable
5im2A-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 VAL A 705
ALA A 703
PHE A 666
None
0.87A 5js1A-5z9sA:
undetectable
5js1A-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
10 / 12 LEU A  67
ASP A  96
PHE A 145
ARG A 159
LYS A 202
HIS A 203
MET A 246
MET A 314
TRP A 422
GLU A 524
None
BGC  A 801 (-3.0A)
BGC  A 801 (-4.6A)
BGC  A 801 (-2.6A)
BGC  A 801 (-2.8A)
BGC  A 801 (-3.9A)
BGC  A 801 (-3.7A)
BGC  A 801 (-4.3A)
None
BGC  A 801 (-2.6A)
0.56A 5m6gA-5z9sA:
37.9
5m6gA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 ALA A 607
GLN A 450
THR A 452
None
0.75A 5n0oA-5z9sA:
1.6
5n0oA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 LYS A 563
TRP A 594
SER A 562
None
1.38A 5nwwA-5z9sA:
undetectable
5nwwA-5z9sA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
3 / 3 GLU A 693
HIS A 691
VAL A 674
None
0.88A 5trqB-5z9sA:
undetectable
5trqB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 LEU A 448
GLY A 603
LEU A 611
THR A 614
LEU A 613
None
0.97A 5twjA-5z9sA:
undetectable
5twjA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 ARG A 404
VAL A 408
GLU A 500
SER A 461
None
1.25A 5umwA-5z9sA:
undetectable
5umwF-5z9sA:
undetectable
5umwA-5z9sA:
20.88
5umwF-5z9sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 LEU A 170
VAL A 705
GLU A 384
SER A 617
None
1.33A 5umwA-5z9sA:
undetectable
5umwF-5z9sA:
undetectable
5umwA-5z9sA:
20.88
5umwF-5z9sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 7 LEU A 174
VAL A 705
GLU A 384
SER A 617
None
1.27A 5umwA-5z9sA:
undetectable
5umwF-5z9sA:
undetectable
5umwA-5z9sA:
20.88
5umwF-5z9sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 4 LEU A 411
GLY A 516
SER A 561
SER A 562
None
1.09A 5uunB-5z9sA:
undetectable
5uunB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 PHE A 624
LEU A 540
ALA A 412
ILE A 560
ALA A 595
None
1.00A 5vc0A-5z9sA:
undetectable
5vc0A-5z9sA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
4 / 8 GLY A 206
ILE A 151
GLN A 113
TRP A 157
None
0.98A 5vlmH-5z9sA:
1.4
5vlmH-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 VAL A 566
PRO A 625
GLU A 166
THR A 163
GLY A 165
None
1.17A 5xiqA-5z9sA:
undetectable
5xiqA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ASP A 215
LEU A 263
LEU A 264
ALA A 219
LEU A 226
None
0.93A 6ew0B-5z9sA:
undetectable
6ew0B-5z9sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ASP A 215
LEU A 263
LEU A 264
ALA A 219
LEU A 226
None
0.94A 6ew0D-5z9sA:
undetectable
6ew0D-5z9sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ASP A 215
LEU A 263
LEU A 264
ALA A 219
LEU A 226
None
0.93A 6ew0H-5z9sA:
undetectable
6ew0H-5z9sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 ASP A 215
LEU A 263
LEU A 264
ALA A 219
LEU A 226
None
0.93A 6ew0I-5z9sA:
undetectable
6ew0I-5z9sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 GLY A 370
GLY A 106
SER A 371
THR A 108
ASN A 378
None
1.08A 6exiA-5z9sA:
2.4
6exiA-5z9sA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 10 GLY A 370
GLY A 106
SER A 371
THR A 108
ASN A 378
None
1.09A 6exiB-5z9sA:
2.6
6exiB-5z9sA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLY A 370
GLY A 106
SER A 371
THR A 108
ASN A 378
None
1.07A 6exiC-5z9sA:
2.2
6exiD-5z9sA:
2.2
6exiC-5z9sA:
25.88
6exiD-5z9sA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 GLY A 370
GLY A 106
SER A 371
THR A 108
ASN A 378
None
1.07A 6exiC-5z9sA:
2.4
6exiD-5z9sA:
2.2
6exiC-5z9sA:
25.88
6exiD-5z9sA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum)
5 / 12 VAL A 566
PRO A 625
GLU A 166
THR A 163
GLY A 165
None
1.18A 6mn8A-5z9sA:
undetectable
6mn8A-5z9sA:
undetectable