SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 6 LEU A 232
ASP A 228
LEU A 225
GLY A 222
 None
MG  A 502 (-3.5A)
None
None
 0.84A 1mt1G-5z9xA:
undetectable
1mt1J-5z9xA:
undetectable		 1mt1G-5z9xA:
19.51
1mt1J-5z9xA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 6 LEU A 232
ASP A 228
LEU A 225
GLY A 222
 None
MG  A 502 (-3.5A)
None
None
 0.94A 1n13H-5z9xA:
undetectable
1n13K-5z9xA:
undetectable		 1n13H-5z9xA:
15.93
1n13K-5z9xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 7 LEU A 232
ASP A 228
LEU A 225
GLY A 222
 None
MG  A 502 (-3.5A)
None
None
 0.91A 1n13G-5z9xA:
undetectable
1n13J-5z9xA:
undetectable		 1n13G-5z9xA:
19.51
1n13J-5z9xA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 236
LEU A  85
THR A 138
ILE A 219
MET A 140
 None
 1.34A 1xomB-5z9xA:
undetectable		 1xomB-5z9xA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 7 LEU A 232
ASP A 228
LEU A 225
GLY A 222
 None
MG  A 502 (-3.5A)
None
None
 0.84A 2qqcD-5z9xA:
undetectable
2qqcE-5z9xA:
undetectable		 2qqcD-5z9xA:
18.64
2qqcE-5z9xA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 236
LEU A  85
THR A 138
ILE A 219
MET A 140
 None
 1.31A 3g4lB-5z9xA:
undetectable		 3g4lB-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 236
LEU A  85
THR A 138
ILE A 219
MET A 140
 None
 1.33A 3g4lD-5z9xA:
undetectable		 3g4lD-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 7 TYR A 109
ASN A  78
ASP A 235
SER A 125
 None
 1.27A 3lslA-5z9xA:
undetectable
3lslD-5z9xA:
undetectable		 3lslA-5z9xA:
undetectable
3lslD-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 7 SER A 125
TYR A 109
ASN A  78
ASP A 235
 None
 1.21A 3lslA-5z9xA:
undetectable
3lslD-5z9xA:
undetectable		 3lslA-5z9xA:
undetectable
3lslD-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_1
(MNMC2)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 4 GLU A 146
ASP A 195
ASP A 187
GLU A 194
 MG  A 503 (-3.1A)
None
None
None
 1.37A 3vywB-5z9xA:
undetectable		 3vywB-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 5 GLU A 146
ASP A 195
ASP A 187
GLU A 194
 MG  A 503 (-3.1A)
None
None
None
 1.39A 3vywD-5z9xA:
undetectable		 3vywD-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 225
VAL A 160
GLY A 161
CYH A 280
LEU A 232
 None
 1.43A 4ot2A-5z9xA:
undetectable		 4ot2A-5z9xA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 5 ASP A 183
VAL A 158
ASP A 195
GLY A 190
 None
 1.05A 4xp6A-5z9xA:
undetectable		 4xp6A-5z9xA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 5 LEU A  73
LYS A  74
ALA A  77
LEU A  80
 None
 0.74A 5vkqA-5z9xA:
undetectable
5vkqD-5z9xA:
undetectable		 5vkqA-5z9xA:
undetectable
5vkqD-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 5 LEU A  73
LYS A  74
ALA A  77
LEU A  80
 None
 0.74A 5vkqA-5z9xA:
undetectable
5vkqB-5z9xA:
undetectable		 5vkqA-5z9xA:
undetectable
5vkqB-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 5 LEU A  73
LYS A  74
ALA A  77
LEU A  80
 None
 0.73A 5vkqB-5z9xA:
undetectable
5vkqC-5z9xA:
undetectable		 5vkqB-5z9xA:
undetectable
5vkqC-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5z9x SMALL RNA DEGRADING
NUCLEASE 1
(Arabidopsis
thaliana) 		4 / 5 LEU A  73
LYS A  74
ALA A  77
LEU A  80
 None
 0.73A 5vkqC-5z9xA:
undetectable
5vkqD-5z9xA:
undetectable		 5vkqC-5z9xA:
undetectable
5vkqD-5z9xA:
undetectable