SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5z9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 THR A  42
PRO A  68
THR A  67
PRO A  70
 None
 1.28A 1a7yA-5z9yA:
undetectable
1a7yC-5z9yA:
undetectable		 1a7yA-5z9yA:
undetectable
1a7yC-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A  67
THR A  42
PRO A  68
 None
 0.80A 1dscC-5z9yA:
undetectable		 1dscC-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 115
VAL A 151
TYR A 132
PRO A 137
LEU A 139
 None
 1.22A 1klmA-5z9yA:
undetectable		 1klmA-5z9yA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 183
LEU A 206
ALA A  36
ALA A 220
MET A 223
 None
DXP  A 301 (-4.7A)
None
None
None
 1.36A 1kt4A-5z9yA:
undetectable		 1kt4A-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  40
THR A  39
LEU A  61
 None
 0.71A 1v8bC-5z9yA:
2.8		 1v8bC-5z9yA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  61
ASN A  62
LEU A  64
GLY A  65
LEU A  92
 None
 1.06A 2oz7A-5z9yA:
undetectable		 2oz7A-5z9yA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 SER A 156
GLY A 155
GLY A 159
GLY A 188
 None
None
DXP  A 301 (-3.6A)
None
 0.88A 3bogB-5z9yA:
undetectable
3bogD-5z9yA:
undetectable		 3bogB-5z9yA:
undetectable
3bogD-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 227
ILE A 187
ILE A 158
MET A  19
LEU A  17
 None
None
DXP  A 301 (-4.1A)
None
None
 1.15A 4a84A-5z9yA:
undetectable		 4a84A-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A  32
THR A  21
LEU A  61
LEU A  64
 None
 1.01A 4lvcB-5z9yA:
2.4		 4lvcB-5z9yA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 218
ALA A 221
ALA A 222
ALA A 225
 None
 0.12A 4oadA-5z9yA:
undetectable		 4oadA-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 136
ALA A 140
THR A 134
THR A 133
 None
 1.45A 4w5rA-5z9yA:
undetectable		 4w5rA-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 136
ALA A 140
THR A 134
THR A 133
 None
 1.47A 4z4gA-5z9yA:
undetectable		 4z4gA-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 THR A  39
ILE A  18
THR A 211
LEU A  30
LEU A  57
 None
 1.23A 4ze0A-5z9yA:
undetectable		 4ze0A-5z9yA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  66
GLY A  20
THR A  43
LEU A 206
 None
DXP  A 301 ( 3.8A)
DXP  A 301 (-3.3A)
DXP  A 301 (-4.7A)
 1.04A 5hwaA-5z9yA:
undetectable		 5hwaA-5z9yA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 206
SER A 156
GLY A 163
GLY A 188
ARG A 212
 DXP  A 301 (-4.7A)
None
None
None
None
 1.34A 5o4yD-5z9yA:
undetectable
5o4yE-5z9yA:
undetectable		 5o4yD-5z9yA:
undetectable
5o4yE-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 227
LEU A 206
LEU A 183
ILE A 164
ALA A 196
 None
DXP  A 301 (-4.7A)
None
None
None
 1.40A 5xprA-5z9yA:
undetectable		 5xprA-5z9yA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5z9y THIAZOLE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 207
GLY A 159
THR A 160
GLY A 186
LEU A  30
 DXP  A 301 (-3.6A)
DXP  A 301 (-3.6A)
None
DXP  A 301 (-3.7A)
None
 1.17A 5ybbA-5z9yA:
undetectable		 5ybbA-5z9yA:
undetectable