SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5za2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 LEU A  69
LEU A 178
LEU A 173
GLN A 168
THR A 187
 None
 1.37A 1a28B-5za2A:
undetectable		 1a28B-5za2A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 LEU A 247
PHE A 327
ALA A 237
GLY A 240
HIS A 255
 None
 1.29A 1brpA-5za2A:
undetectable		 1brpA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 LEU A 182
PHE A 234
LEU A 247
ILE A 224
VAL A  79
 None
 1.19A 1hrkA-5za2A:
undetectable		 1hrkA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 6 SER A 165
PHE A  83
PHE A 158
GLY A  74
 None
 1.10A 1icuC-5za2A:
undetectable
1icuD-5za2A:
undetectable		 1icuC-5za2A:
16.84
1icuD-5za2A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 5 PHE A 158
GLY A  74
SER A 165
PHE A  83
 None
 1.18A 1icuC-5za2A:
undetectable
1icuD-5za2A:
undetectable		 1icuC-5za2A:
16.84
1icuD-5za2A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 10 GLY A  63
GLN A 120
ASN A 152
TYR A 222
THR A 315
GLY A 316
 NXL  A 401 (-3.8A)
NXL  A 401 ( 3.3A)
NXL  A 401 (-3.6A)
EPE  A 405 (-4.0A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.4A)
 1.29A 1kvlA-5za2A:
55.2		 1kvlA-5za2A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		8 / 10 LEU A 119
GLN A 120
TYR A 150
ASN A 152
TYR A 222
LYS A 314
THR A 315
GLY A 316
 NXL  A 401 (-4.6A)
NXL  A 401 ( 3.3A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.6A)
EPE  A 405 (-4.0A)
NXL  A 401 (-2.9A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.4A)
 0.28A 1kvlA-5za2A:
55.2		 1kvlA-5za2A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 ILE A  62
GLY A  63
GLY A 319
ALA A 221
LEU A  69
 None
NXL  A 401 (-3.8A)
EPE  A 405 (-4.0A)
None
None
 1.04A 1vptA-5za2A:
undetectable		 1vptA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 11 THR A 318
GLY A 320
GLY A 202
ILE A  62
LEU A 338
ALA A 323
 EPE  A 405 (-4.1A)
None
None
None
None
None
 1.42A 1x7pA-5za2A:
undetectable
1x7pB-5za2A:
undetectable		 1x7pA-5za2A:
undetectable
1x7pB-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 10 THR A 318
GLY A 320
GLY A 202
ILE A  62
LEU A 338
ALA A 323
 EPE  A 405 (-4.1A)
None
None
None
None
None
 1.48A 1x7pA-5za2A:
undetectable
1x7pB-5za2A:
undetectable		 1x7pA-5za2A:
undetectable
1x7pB-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 5 ALA A  75
TYR A  76
ALA A  71
GLN A 168
 None
 1.06A 1xl6A-5za2A:
undetectable
1xl6B-5za2A:
undetectable		 1xl6A-5za2A:
16.03
1xl6B-5za2A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 LEU A 178
LEU A 173
TYR A  76
SER A 165
ALA A  71
 None
 1.19A 2bm9D-5za2A:
undetectable		 2bm9D-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 ALA A 221
GLY A 223
MET A 174
LEU A 179
LEU A 182
 None
 0.99A 2hw2A-5za2A:
undetectable		 2hw2A-5za2A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 6 ILE A  15
MET A 337
ILE A 335
HIS A 353
 None
 0.96A 3eteA-5za2A:
undetectable
3eteE-5za2A:
undetectable		 3eteA-5za2A:
11.33
3eteE-5za2A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 5 ILE A  15
MET A 337
ILE A 335
HIS A 353
 None
 0.95A 3eteB-5za2A:
undetectable
3eteC-5za2A:
undetectable		 3eteB-5za2A:
11.33
3eteC-5za2A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 7 MET A 337
ILE A 335
HIS A 353
ILE A  15
 None
 0.97A 3eteD-5za2A:
undetectable
3eteF-5za2A:
undetectable		 3eteD-5za2A:
11.33
3eteF-5za2A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 LYS A  67
ASN A 152
LYS A 314
THR A 315
GLY A 316
 NXL  A 401 ( 3.8A)
NXL  A 401 (-3.6A)
NXL  A 401 (-2.9A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.4A)
 0.32A 3huoA-5za2A:
15.6		 3huoA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 12 SER A  64
LYS A  67
ASN A 152
GLY A 316
THR A 318
ARG A 348
 NXL  A 401 (-1.3A)
NXL  A 401 ( 3.8A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.4A)
EPE  A 405 (-4.1A)
None
 0.97A 3mzeA-5za2A:
14.8		 3mzeA-5za2A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 12 SER A  64
LYS A  67
ASN A 152
THR A 315
GLY A 316
THR A 318
 NXL  A 401 (-1.3A)
NXL  A 401 ( 3.8A)
NXL  A 401 (-3.6A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.4A)
EPE  A 405 (-4.1A)
 0.67A 3mzeA-5za2A:
14.8		 3mzeA-5za2A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 THR A 226
SER A  55
ILE A  16
ALA A 351
VAL A  65
 None
GOL  A 403 (-2.7A)
None
None
None
 1.26A 3vw1D-5za2A:
undetectable		 3vw1D-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 PHE A 300
PRO A 303
PHE A 258
TYR A 312
ALA A 305
 None
 1.34A 4a83A-5za2A:
undetectable		 4a83A-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 PHE A 300
PRO A 303
PHE A 258
TYR A 312
ALA A 305
 None
 1.33A 4a84A-5za2A:
undetectable		 4a84A-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 5 HIS A 255
LEU A 231
LEU A  69
ASP A 230
 None
 1.32A 4aqlA-5za2A:
undetectable		 4aqlA-5za2A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 GLY A  27
ALA A  46
ARG A  24
ILE A  25
LEU A 338
 None
GOL  A 402 ( 3.9A)
None
None
None
 1.16A 4azsA-5za2A:
undetectable		 4azsA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 GLY A  27
ALA A  46
ARG A  24
ILE A  25
LEU A 338
 None
GOL  A 402 ( 3.9A)
None
None
None
 1.16A 4azwA-5za2A:
undetectable		 4azwA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 7 PHE A  83
ALA A 107
THR A 111
LEU A 253
 None
 1.06A 4ejgA-5za2A:
undetectable		 4ejgA-5za2A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 4 ALA A  78
HIS A  92
PHE A  83
LEU A 166
 None
 1.46A 4lufA-5za2A:
0.1		 4lufA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 5 GLY A 227
SER A 228
ALA A 229
GLU A  56
 None
 0.73A 4m93B-5za2A:
undetectable
4m93C-5za2A:
undetectable		 4m93B-5za2A:
undetectable
4m93C-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 8 ALA A 339
ASP A  13
ILE A  16
ILE A 355
 None
 0.92A 4ndnB-5za2A:
undetectable		 4ndnB-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 8 ALA A 339
ASP A  13
ILE A  16
ILE A 355
 None
 0.94A 4ndnD-5za2A:
undetectable		 4ndnD-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 4 GLU A 271
GLY A 267
HIS A 259
ARG A 148
 None
 1.32A 4r82A-5za2A:
undetectable
4r82B-5za2A:
undetectable		 4r82A-5za2A:
undetectable
4r82B-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 5 LEU A  85
ASP A  86
LEU A 253
THR A 111
 None
 1.23A 4wozF-5za2A:
undetectable
4wozH-5za2A:
undetectable		 4wozF-5za2A:
undetectable
4wozH-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 10 GLY A 156
LEU A 217
GLN A 168
ASN A 164
LEU A 161
 None
 1.18A 5fhzC-5za2A:
undetectable		 5fhzC-5za2A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 12 THR A 318
GLY A 320
GLY A 202
ILE A  62
LEU A 338
ALA A 323
 EPE  A 405 (-4.1A)
None
None
None
None
None
 1.39A 5l0zA-5za2A:
undetectable		 5l0zA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 10 LEU A 117
ALA A 162
SER A 165
THR A 111
LEU A  85
 None
 1.43A 5mm4B-5za2A:
undetectable		 5mm4B-5za2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 8 ALA A 339
ASP A  13
ILE A  16
ILE A 355
 None
 0.93A 5t8sA-5za2A:
undetectable		 5t8sA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 4 GLU A 220
THR A  70
THR A 177
LEU A 166
 None
 1.48A 5v96A-5za2A:
undetectable		 5v96A-5za2A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 4 GLU A 220
THR A  70
THR A 177
LEU A 166
 None
 1.49A 5v96B-5za2A:
undetectable		 5v96B-5za2A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 4 GLU A 220
THR A  70
THR A 177
LEU A 166
 None
 1.47A 5v96C-5za2A:
undetectable		 5v96C-5za2A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 4 GLU A 220
THR A  70
THR A 177
LEU A 166
 None
 1.47A 5v96D-5za2A:
undetectable		 5v96D-5za2A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		4 / 7 ALA A 339
ASP A  13
ILE A  16
ILE A 355
 None
 0.91A 6fbnA-5za2A:
undetectable		 6fbnA-5za2A:
undetectable