SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5zai -
(-) 		5 / 12 ARG A 121
ILE A 103
LEU A 108
ALA A 107
LEU A 116
 None
None
COA  A 301 (-4.7A)
None
None
 1.22A 1og5B-5zaiA:
undetectable		 1og5B-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5zai -
(-) 		4 / 7 GLU A 113
GLY A  64
PHE A  70
ILE A 138
 None
COA  A 301 ( 4.3A)
COA  A 301 (-4.8A)
None
 1.02A 2qmzA-5zaiA:
undetectable
2qmzB-5zaiA:
undetectable		 2qmzA-5zaiA:
undetectable
2qmzB-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5zai -
(-) 		4 / 5 LEU A 116
LEU A 131
GLY A 130
GLY A 109
 None
None
None
COA  A 301 ( 4.2A)
 0.80A 3si7C-5zaiA:
undetectable
3si7D-5zaiA:
undetectable		 3si7C-5zaiA:
undetectable
3si7D-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 5zai -
(-) 		5 / 12 ALA A 127
ILE A 103
LEU A 148
VAL A 151
ILE A 167
 EDO  A 304 (-4.7A)
None
None
None
GOL  A 307 (-4.0A)
 1.05A 4km2A-5zaiA:
undetectable		 4km2A-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 5zai -
(-) 		5 / 12 ALA A 127
ILE A 103
LEU A 148
VAL A 151
ILE A 167
 EDO  A 304 (-4.7A)
None
None
None
GOL  A 307 (-4.0A)
 1.05A 4km2B-5zaiA:
undetectable		 4km2B-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5zai -
(-) 		5 / 11 GLU A 113
LEU A 114
LEU A  28
LEU A  33
LEU A  36
 None
 1.00A 4wg0C-5zaiA:
undetectable
4wg0D-5zaiA:
undetectable
4wg0E-5zaiA:
undetectable		 4wg0C-5zaiA:
undetectable
4wg0D-5zaiA:
undetectable
4wg0E-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5zai -
(-) 		5 / 11 GLU A 113
LEU A 114
LEU A  28
LEU A  33
LEU A  36
 None
 0.99A 4wg0E-5zaiA:
undetectable
4wg0F-5zaiA:
undetectable
4wg0G-5zaiA:
undetectable		 4wg0E-5zaiA:
undetectable
4wg0F-5zaiA:
undetectable
4wg0G-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5zai -
(-) 		4 / 5 ILE A 198
VAL A  51
ILE A  53
THR A 191
 None
 0.72A 4xdtA-5zaiA:
undetectable		 4xdtA-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zai -
(-) 		5 / 9 PHE A  70
ILE A  67
PHE A  81
LEU A  33
LEU A  32
 COA  A 301 (-4.8A)
COA  A 301 (-4.0A)
None
None
None
 1.18A 4ze0A-5zaiA:
undetectable		 4ze0A-5zaiA:
undetectable