SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 TYR A 452
VAL A 309
ILE A 355
GLY A 314
None
0.97A 11gsA-5zalA:
undetectable
11gsA-5zalA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 LEU A 858
SER A 855
THR A 993
HIS A1041
TYR A 852
None
1.38A 1kw0A-5zalA:
undetectable
1kw0A-5zalA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 SER A1737
PRO A1850
SER A1852
LEU A1841
LEU A1735
None
1.27A 1lbcA-5zalA:
undetectable
1lbcC-5zalA:
undetectable
1lbcA-5zalA:
13.08
1lbcC-5zalA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 LEU A 219
GLU A 220
ILE A 582
TYR A 543
None
1.15A 1qvtA-5zalA:
undetectable
1qvtA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 PHE A1666
TYR A1692
TYR A1694
None
0.90A 1x70B-5zalA:
undetectable
1x70B-5zalA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)
5zal RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo
sapiens)
5 / 12 LEU B 298
GLY B 291
GLY B 349
ARG B 344
TYR B 311
None
1.08A 1y4lA-5zalB:
undetectable
1y4lA-5zalB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 ALA A1686
TYR A1692
TYR A  83
PHE A1666
None
1.21A 2ajvH-5zalA:
undetectable
2ajvL-5zalA:
undetectable
2ajvH-5zalA:
19.34
2ajvL-5zalA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 MET A1808
TYR A1701
PHE A1766
GLY A1809
ILE A1811
None
1.39A 2dcfA-5zalA:
undetectable
2dcfA-5zalA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 LEU A1298
LEU A1566
ALA A1565
LEU A1365
LEU A1303
None
1.29A 2oaxB-5zalA:
undetectable
2oaxB-5zalA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 LEU A1298
LEU A1566
ALA A1565
LEU A1365
LEU A1303
None
1.29A 2oaxD-5zalA:
undetectable
2oaxD-5zalA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 LEU A1298
LEU A1566
ALA A1565
LEU A1365
LEU A1303
None
1.18A 2oaxE-5zalA:
undetectable
2oaxE-5zalA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 VAL A1740
THR A1328
ALA A1710
ASP A1713
ARG A1736
None
1.06A 2qm9A-5zalA:
undetectable
2qm9A-5zalA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 10 MET A1808
TYR A1701
PHE A1766
GLY A1809
ILE A1811
None
1.38A 2zm7A-5zalA:
undetectable
2zm7A-5zalA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 10 MET A1808
TYR A1701
PHE A1766
GLY A1809
ILE A1811
None
1.38A 2zm8A-5zalA:
undetectable
2zm8A-5zalA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 11 MET A1808
TYR A1701
PHE A1766
GLY A1809
ILE A1811
None
1.39A 2zmaA-5zalA:
undetectable
2zmaA-5zalA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 LYS A  79
TYR A1692
ASN A1695
PHE A1610
None
1.02A 3bjwD-5zalA:
undetectable
3bjwD-5zalA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 THR A 348
SER A 299
PHE A 280
None
0.84A 3d4sA-5zalA:
undetectable
3d4sA-5zalA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 11 LEU A1732
LEU A1739
ALA A1847
VAL A1849
LYS A1844
None
1.14A 3e22B-5zalA:
undetectable
3e22B-5zalA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
6 / 12 ILE A 829
VAL A 772
GLY A 803
PHE A 802
LEU A1054
LEU A1061
None
1.37A 3em0B-5zalA:
undetectable
3em0B-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 CYH A  63
THR A 206
HIS A 178
LEU A 226
LYS A 222
None
1.07A 3gwxB-5zalA:
undetectable
3gwxB-5zalA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 11 PRO A1850
SER A1852
LEU A1841
LEU A1735
SER A1737
None
1.26A 3h6tA-5zalA:
undetectable
3h6tC-5zalA:
undetectable
3h6tA-5zalA:
13.08
3h6tC-5zalA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 11 SER A1737
PRO A1850
SER A1852
LEU A1841
LEU A1735
None
1.22A 3h6tA-5zalA:
undetectable
3h6tC-5zalA:
undetectable
3h6tA-5zalA:
13.08
3h6tC-5zalA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 GLU A1813
LEU A1712
ASP A1713
None
0.45A 3ko0A-5zalA:
undetectable
3ko0A-5zalA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 GLU A1813
LEU A1712
ASP A1713
None
0.44A 3ko0T-5zalA:
undetectable
3ko0T-5zalA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 LEU A 358
ASP A 319
ALA A 318
TYR A 267
None
1.21A 3rodD-5zalA:
undetectable
3rodD-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 5 ASP A1810
ILE A1769
PRO A1805
PHE A1772
None
1.09A 3s3vA-5zalA:
undetectable
3s3vA-5zalA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 CYH A  63
THR A 206
HIS A 178
VAL A 594
ILE A 223
None
1.23A 3sp9A-5zalA:
undetectable
3sp9A-5zalA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 5 ASP A 215
GLY A 212
TYR A 543
GLU A 542
None
1.39A 3w9tA-5zalA:
undetectable
3w9tA-5zalA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 5 ASP A 215
GLY A 212
TYR A 543
GLU A 542
None
1.39A 3w9tC-5zalA:
undetectable
3w9tC-5zalA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 5 ASP A 215
GLY A 212
TYR A 543
GLU A 542
None
1.39A 3w9tD-5zalA:
undetectable
3w9tD-5zalA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 5 ASP A 215
GLY A 212
TYR A 543
GLU A 542
None
1.38A 3w9tG-5zalA:
undetectable
3w9tG-5zalA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 10 GLY A 204
ALA A  74
VAL A 173
GLU A  80
SER A 232
None
1.20A 4da7A-5zalA:
2.3
4da7A-5zalA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 TYR A1757
ARG A  86
SER A1664
None
1.15A 4dr2I-5zalA:
undetectable
4dr2J-5zalA:
undetectable
4dr2I-5zalA:
19.53
4dr2J-5zalA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
1.13A 4feuB-5zalA:
undetectable
4feuB-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.97A 4feuD-5zalA:
undetectable
4feuD-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.95A 4feuF-5zalA:
undetectable
4feuF-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.95A 4fevB-5zalA:
undetectable
4fevB-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.93A 4fevD-5zalA:
undetectable
4fevD-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.95A 4fevF-5zalA:
undetectable
4fevF-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.96A 4fewB-5zalA:
undetectable
4fewB-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.96A 4fewD-5zalA:
undetectable
4fewD-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.98A 4fewF-5zalA:
undetectable
4fewF-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.97A 4fexB-5zalA:
undetectable
4fexB-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 6 ARG A1855
GLY A1730
ASN A1311
GLU A1313
None
1.19A 4g0vB-5zalA:
undetectable
4g0vB-5zalA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.98A 4gkhB-5zalA:
undetectable
4gkhB-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.97A 4gkhD-5zalA:
undetectable
4gkhD-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.95A 4gkhF-5zalA:
undetectable
4gkhF-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.96A 4gkhG-5zalA:
undetectable
4gkhG-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 6 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.94A 4gkhJ-5zalA:
undetectable
4gkhJ-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.95A 4gkhC-5zalA:
undetectable
4gkhK-5zalA:
undetectable
4gkhC-5zalA:
13.33
4gkhK-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.97A 4gkiA-5zalA:
undetectable
4gkiA-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.96A 4gkiC-5zalA:
undetectable
4gkiC-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 8 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.96A 4gkiE-5zalA:
undetectable
4gkiG-5zalA:
undetectable
4gkiE-5zalA:
13.33
4gkiG-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 TYR A1757
ARG A  86
SER A1664
None
1.15A 4lf7I-5zalA:
undetectable
4lf7J-5zalA:
undetectable
4lf7I-5zalA:
19.53
4lf7J-5zalA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 TYR A1757
ARG A  86
SER A1664
None
1.15A 4lf8I-5zalA:
undetectable
4lf8J-5zalA:
undetectable
4lf8I-5zalA:
19.53
4lf8J-5zalA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 6 LEU A1359
ASN A1355
LEU A1567
ILE A1327
None
1.12A 4okxA-5zalA:
undetectable
4okxA-5zalA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 9 PHE A1812
ALA A1816
ALA A1818
LEU A1683
VAL A1833
None
1.36A 4or0A-5zalA:
2.7
4or0A-5zalA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 ASP A1713
LYS A1718
LEU A1571
None
1.07A 4ptjA-5zalA:
undetectable
4ptjA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5zal ENDORIBONUCLEASE
DICER
RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo
sapiens;
Homo
sapiens)
3 / 3 ASP A 349
LYS A 354
LEU B 359
None
0.89A 4ptjA-5zalA:
undetectable
4ptjA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 TYR A1752
GLY A1809
PHE A1812
ASP A1709
GLY A1708
None
1.27A 4qa0A-5zalA:
2.4
4qa0A-5zalA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 TYR A 664
GLY A 681
PRO A 682
None
0.71A 4qwpA-5zalA:
undetectable
4qwpA-5zalA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 GLU A1313
ARG A1855
THR A1733
GLY A1730
None
0.92A 4qwpB-5zalA:
undetectable
4qwpB-5zalA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 PHE A 894
MET A 842
LEU A 838
LEU A 881
LEU A 879
None
1.00A 4qynB-5zalA:
undetectable
4qynB-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 PHE A 894
MET A 842
LEU A 838
LEU A 881
LEU A 879
None
1.01A 4qzuC-5zalA:
undetectable
4qzuC-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 VAL A 312
ILE A 446
ALA A 454
ILE A 445
None
0.75A 4uxqA-5zalA:
undetectable
4uxqA-5zalA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)
5zal RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo
sapiens)
4 / 4 LEU B 301
VAL B 297
GLU B 300
ARG B 296
None
1.09A 4ww7A-5zalB:
undetectable
4ww7A-5zalB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 VAL A 715
THR A 719
ARG A 636
None
0.70A 5b2sB-5zalA:
undetectable
5b2sB-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 VAL A 715
THR A 719
ARG A 636
None
0.70A 5b2tB-5zalA:
2.3
5b2tB-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 6 TYR A1335
GLY A1341
SER A1344
LEU A1343
None
1.04A 5bphA-5zalA:
undetectable
5bphA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 4 TYR A1335
GLY A1341
SER A1344
LEU A1343
None
1.02A 5bphC-5zalA:
undetectable
5bphC-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 6 TYR A1335
GLY A1341
SER A1344
LEU A1343
None
1.12A 5bphD-5zalA:
undetectable
5bphD-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 5 LEU A1704
ALA A1816
LEU A1707
VAL A1833
None
1.14A 5cr1A-5zalA:
undetectable
5cr1A-5zalA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 ASP A1875
ARG A1906
ARG A1907
None
0.84A 5eajB-5zalA:
undetectable
5eajB-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)
5zal ENDORIBONUCLEASE
DICER
RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo
sapiens)
5 / 9 THR A 350
LEU A 346
PRO B 333
ILE A 333
LEU A 345
None
1.33A 5g48B-5zalA:
undetectable
5g48B-5zalA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)
5zal RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo
sapiens)
4 / 4 GLY B 339
CYH B 325
ARG B 354
GLY B 349
None
1.48A 5inzA-5zalB:
undetectable
5inzC-5zalB:
undetectable
5inzD-5zalB:
undetectable
5inzA-5zalB:
undetectable
5inzC-5zalB:
undetectable
5inzD-5zalB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 HIS A1339
HIS A 703
ILE A 705
ARG A1342
None
1.15A 5kkzC-5zalA:
undetectable
5kkzE-5zalA:
undetectable
5kkzC-5zalA:
undetectable
5kkzE-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 HIS A 703
ILE A 705
ARG A1342
HIS A1339
None
1.19A 5kkzK-5zalA:
undetectable
5kkzQ-5zalA:
undetectable
5kkzK-5zalA:
undetectable
5kkzQ-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 7 HIS A1339
HIS A 703
ILE A 705
ARG A1342
None
1.14A 5kkzM-5zalA:
undetectable
5kkzO-5zalA:
undetectable
5kkzM-5zalA:
undetectable
5kkzO-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 4 GLN A1073
THR A1074
LEU A1567
LEU A1566
None
1.16A 5m5kB-5zalA:
undetectable
5m5kB-5zalA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 5 TYR A 668
SER A1691
ALA A1690
GLN A1614
None
1.26A 5n0wB-5zalA:
undetectable
5n0wB-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 5 TYR A 668
SER A1691
ALA A1690
GLN A1614
None
1.30A 5n4iA-5zalA:
undetectable
5n4iA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 HIS A1719
GLU A1722
TRP A1831
None
1.10A 5odiD-5zalA:
undetectable
5odiD-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 HIS A1719
GLU A1722
TRP A1831
None
1.15A 5odqD-5zalA:
undetectable
5odqD-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 HIS A1719
GLU A1722
TRP A1831
None
1.11A 5odrD-5zalA:
undetectable
5odrD-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 MET A1821
GLU A1608
ARG A1607
None
1.06A 5tjyA-5zalA:
2.2
5tjyA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
3 / 3 MET A1821
GLU A1608
ARG A1607
None
1.11A 5tjzA-5zalA:
2.7
5tjzA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 4 GLY A1009
ARG A 996
ASN A1006
LEU A1005
None
1.45A 6b58A-5zalA:
undetectable
6b58A-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
5 / 12 GLN A1613
ASP A1699
LEU A1684
ALA A1681
LEU A1662
None
0.86A 6bq4A-5zalA:
3.9
6bq4A-5zalA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)
5zal ENDORIBONUCLEASE
DICER

(Homo
sapiens)
4 / 6 ILE A1673
TYR A1754
LEU A1815
VAL A1833
None
0.85A 6f6jA-5zalA:
undetectable
6f6jA-5zalA:
undetectable