SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5zb3 -
(-) 		4 / 6 PHE A 326
GLU A 340
GLY A 373
PHE A 335
 None
 1.12A 1kqbC-5zb3A:
undetectable
1kqbD-5zb3A:
undetectable		 1kqbC-5zb3A:
undetectable
1kqbD-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 5zb3 -
(-) 		4 / 7 ALA A 378
GLY A 385
ILE A 392
THR A 402
 None
 0.80A 1t7iB-5zb3A:
undetectable		 1t7iB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5zb3 -
(-) 		4 / 7 ALA A 378
GLY A 385
ILE A 392
THR A 402
 None
 0.83A 1t7jB-5zb3A:
undetectable		 1t7jB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5zb3 -
(-) 		5 / 12 THR A 295
PRO A 409
VAL A 257
ILE A 246
VAL A 296
 None
 1.19A 1z9hA-5zb3A:
undetectable		 1z9hA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5zb3 -
(-) 		5 / 12 THR A 295
PRO A 409
VAL A 257
ILE A 246
VAL A 296
 None
 1.21A 1z9hB-5zb3A:
undetectable		 1z9hB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5zb3 -
(-) 		5 / 12 THR A 295
PRO A 409
VAL A 257
ILE A 246
VAL A 296
 None
 1.19A 1z9hC-5zb3A:
undetectable		 1z9hC-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5zb3 -
(-) 		5 / 12 THR A 295
PRO A 409
VAL A 257
ILE A 246
VAL A 296
 None
 1.20A 1z9hD-5zb3A:
undetectable		 1z9hD-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5zb3 -
(-) 		5 / 9 LEU A 377
LEU A 376
ILE A 419
LEU A 331
ILE A 344
 None
 1.08A 2f78A-5zb3A:
undetectable		 2f78A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5zb3 -
(-) 		5 / 9 LEU A 377
LEU A 376
ILE A 419
LEU A 331
ILE A 344
 None
 1.12A 2f78B-5zb3A:
undetectable		 2f78B-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5zb3 -
(-) 		5 / 9 LEU A 415
LEU A 416
ILE A 419
PHE A 326
LEU A 377
 None
 1.13A 2f7aB-5zb3A:
undetectable		 2f7aB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5zb3 -
(-) 		5 / 10 LEU A 377
GLY A 374
LEU A 376
ILE A 419
LEU A 331
 None
 0.97A 2f8dA-5zb3A:
undetectable		 2f8dA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5zb3 -
(-) 		5 / 10 LEU A 377
LEU A 376
ILE A 419
LEU A 331
ILE A 344
 None
 1.09A 2f8dA-5zb3A:
undetectable		 2f8dA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5zb3 -
(-) 		5 / 12 GLN A 387
LEU A 364
ALA A 315
CYH A 319
VAL A 323
 None
 1.42A 2g70A-5zb3A:
undetectable		 2g70A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5zb3 -
(-) 		5 / 12 LEU A 376
VAL A 351
ALA A 315
CYH A 319
VAL A 323
 None
 1.34A 2g70A-5zb3A:
undetectable		 2g70A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5zb3 -
(-) 		5 / 12 LEU A 376
VAL A 351
ALA A 315
CYH A 319
VAL A 323
 None
 1.29A 2g70B-5zb3A:
undetectable		 2g70B-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5zb3 -
(-) 		5 / 12 LEU A 376
VAL A 351
ALA A 315
CYH A 319
VAL A 323
 None
 1.30A 2g72A-5zb3A:
undetectable		 2g72A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5zb3 -
(-) 		5 / 12 LEU A 376
VAL A 351
ALA A 315
CYH A 319
VAL A 323
 None
 1.28A 2g72B-5zb3A:
undetectable		 2g72B-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5zb3 -
(-) 		3 / 3 CYH A 333
CYH A 427
HIS A 423
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.83A 2iwkB-5zb3A:
undetectable		 2iwkB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5zb3 -
(-) 		4 / 6 LEU A 236
LEU A 449
GLU A 287
MET A 413
 None
 1.06A 2kuhA-5zb3A:
undetectable		 2kuhA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5zb3 -
(-) 		5 / 11 LEU A 415
ILE A 419
PHE A 335
PHE A 326
LEU A 381
 None
 1.34A 3a9eB-5zb3A:
undetectable		 3a9eB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5zb3 -
(-) 		3 / 3 CYH A 333
CYH A 427
HIS A 423
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.84A 3dtuB-5zb3A:
undetectable		 3dtuB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5zb3 -
(-) 		3 / 3 CYH A 333
CYH A 427
HIS A 423
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.82A 3dtuD-5zb3A:
undetectable		 3dtuD-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 5zb3 -
(-) 		4 / 8 ALA A 378
GLY A 385
ILE A 392
THR A 402
 None
 0.74A 3el9A-5zb3A:
undetectable		 3el9A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5zb3 -
(-) 		5 / 12 GLY A 278
GLY A 441
ALA A 274
LEU A 328
LEU A 282
 None
 1.07A 3p2kA-5zb3A:
undetectable		 3p2kA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5zb3 -
(-) 		5 / 12 GLY A 278
GLY A 441
ALA A 274
LEU A 328
LEU A 282
 None
 0.97A 3p2kC-5zb3A:
undetectable		 3p2kC-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 5zb3 -
(-) 		5 / 12 GLY A 278
GLY A 441
ALA A 274
LEU A 328
LEU A 282
 None
 0.97A 3p2kD-5zb3A:
undetectable		 3p2kD-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5zb3 -
(-) 		3 / 3 SER A 442
GLY A 441
GLN A 280
 None
 0.57A 3v4tH-5zb3A:
undetectable		 3v4tH-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5zb3 -
(-) 		5 / 11 PHE A 256
PHE A 451
PHE A 450
THR A 314
GLN A 289
 None
 1.28A 4dx7A-5zb3A:
undetectable		 4dx7A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5zb3 -
(-) 		5 / 12 LEU A 328
ALA A 435
LEU A 279
ILE A 419
LEU A 416
 None
 1.17A 4j24D-5zb3A:
undetectable		 4j24D-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5zb3 -
(-) 		5 / 12 TYR A 452
LEU A 376
PHE A 335
PHE A 326
THR A 436
 None
 1.08A 5fsaB-5zb3A:
undetectable		 5fsaB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5zb3 -
(-) 		3 / 3 MET A 386
GLU A 398
ARG A 401
 None
 1.10A 5tjyA-5zb3A:
undetectable		 5tjyA-5zb3A:
undetectable