SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zb8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 5 HIS A   8
HIS A  84
HIS A 139
ASP A 193
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 502 (-2.5A)
 0.74A 1e9yB-5zb8A:
5.0		 1e9yB-5zb8A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 6 HIS A   8
HIS A  10
HIS A  84
HIS A 139
ASP A 193
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 502 (-2.5A)
 0.77A 1fweC-5zb8A:
5.3		 1fweC-5zb8A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 HIS A 183
ASP A 178
ASP A 175
MET A 179
 None
 1.00A 1ilqA-5zb8A:
undetectable
1ilqC-5zb8A:
undetectable		 1ilqA-5zb8A:
16.25
1ilqC-5zb8A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 ASP A   4
ASP A   6
ASN A 191
GLU A 210
 None
 1.11A 1rjdA-5zb8A:
undetectable		 1rjdA-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 ASP A   4
ASP A   6
ASN A 191
GLU A 210
 None
 1.10A 1rjdB-5zb8A:
undetectable		 1rjdB-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 9 ALA A 303
LEU A 237
GLY A 236
PHE A 206
GLY A 203
 None
 1.14A 1ru9H-5zb8A:
undetectable
1ru9L-5zb8A:
undetectable		 1ru9H-5zb8A:
undetectable
1ru9L-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 10 ALA A 303
LEU A 237
GLY A 236
PHE A 206
GLY A 203
 None
 1.10A 1ruaH-5zb8A:
undetectable
1ruaL-5zb8A:
undetectable		 1ruaH-5zb8A:
undetectable
1ruaL-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 7 GLU A 384
LYS A 357
LEU A 394
ALA A 361
 None
 0.94A 1sn0B-5zb8A:
undetectable
1sn0D-5zb8A:
undetectable		 1sn0B-5zb8A:
18.90
1sn0D-5zb8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 7 LYS A  33
GLU A 336
ALA A  30
ALA A 194
 None
 0.90A 1sn0B-5zb8A:
undetectable
1sn0D-5zb8A:
undetectable		 1sn0B-5zb8A:
18.90
1sn0D-5zb8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 12 GLY A 272
ASP A 260
ASP A 281
GLY A 278
ARG A 280
 None
 0.93A 1sqfA-5zb8A:
undetectable		 1sqfA-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.90A 1v7zA-5zb8A:
undetectable		 1v7zA-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.89A 1v7zB-5zb8A:
undetectable		 1v7zB-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.89A 1v7zC-5zb8A:
undetectable		 1v7zC-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.91A 1v7zD-5zb8A:
undetectable		 1v7zD-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.91A 1v7zE-5zb8A:
undetectable		 1v7zE-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.89A 1v7zF-5zb8A:
undetectable		 1v7zF-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 12 ILE A 223
THR A  74
ILE A 231
GLU A 167
PRO A 187
 None
 1.06A 2yzqA-5zb8A:
undetectable		 2yzqA-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.91A 3a6jA-5zb8A:
undetectable		 3a6jA-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 7 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.90A 3a6jB-5zb8A:
undetectable		 3a6jB-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.89A 3a6jC-5zb8A:
undetectable		 3a6jC-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.91A 3a6jE-5zb8A:
undetectable		 3a6jE-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.88A 3a6jF-5zb8A:
undetectable		 3a6jF-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		3 / 3 GLU A 167
HIS A  85
HIS A  84
 None
None
ZN  A 501 (-3.2A)
 0.89A 3co4A-5zb8A:
2.6		 3co4A-5zb8A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 ILE A 341
PRO A 304
ASP A 193
GLY A 203
 None
None
ZN  A 502 (-2.5A)
None
 0.97A 3n3iA-5zb8A:
undetectable		 3n3iA-5zb8A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 12 GLY A  41
GLY A 113
LEU A   7
ASN A 191
PHE A  71
 None
 1.14A 3r24A-5zb8A:
undetectable		 3r24A-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 PHE A 165
ASN A 191
ILE A  72
LEU A  86
 None
 1.05A 3rqwI-5zb8A:
undetectable
3rqwJ-5zb8A:
undetectable		 3rqwI-5zb8A:
undetectable
3rqwJ-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 10 ILE A 345
SER A 396
ILE A 391
ALA A 356
GLU A 353
 None
 1.40A 3u6tA-5zb8A:
undetectable		 3u6tA-5zb8A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		3 / 3 ARG A 240
ARG A 280
ILE A 369
 None
 0.91A 4b7qA-5zb8A:
undetectable		 4b7qA-5zb8A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 5 HIS A   8
HIS A  84
HIS A 139
ASP A 193
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 502 (-2.5A)
 0.71A 4h9mA-5zb8A:
3.0		 4h9mA-5zb8A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		3 / 3 VAL A 226
GLY A 228
LYS A 230
 None
 0.79A 4k50I-5zb8A:
undetectable		 4k50I-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 11 TYR A 158
GLU A  78
HIS A  85
LEU A 154
SER A 153
 None
 1.48A 4m7tA-5zb8A:
undetectable		 4m7tA-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 7 HIS A  10
HIS A   8
HIS A 139
HIS A  84
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
 0.97A 4p6sB-5zb8A:
undetectable		 4p6sB-5zb8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 10 TYR A 148
LEU A 154
ALA A 128
ALA A 121
GLY A 136
 None
 1.42A 4rn6A-5zb8A:
undetectable		 4rn6A-5zb8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 6 HIS A   8
HIS A  10
HIS A  84
HIS A 139
ASP A 193
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 502 (-2.5A)
 0.68A 4ubpC-5zb8A:
4.8		 4ubpC-5zb8A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		6 / 12 GLY A 242
GLY A 373
GLY A 375
ARG A 280
LEU A 237
LEU A 241
 None
 1.29A 5c0oH-5zb8A:
undetectable		 5c0oH-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 12 PRO A 115
SER A  43
GLY A  41
ASP A 193
HIS A   8
 None
None
None
ZN  A 502 (-2.5A)
ZN  A 502 (-3.3A)
 1.27A 5eeiB-5zb8A:
undetectable		 5eeiB-5zb8A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		3 / 3 SER A 153
TYR A 151
TYR A 148
 None
 0.82A 5lakA-5zb8A:
undetectable
5lakI-5zb8A:
undetectable		 5lakA-5zb8A:
undetectable
5lakI-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		3 / 3 SER A 153
TYR A 151
TYR A 148
 None
 0.81A 5lakC-5zb8A:
undetectable
5lakJ-5zb8A:
undetectable		 5lakC-5zb8A:
undetectable
5lakJ-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 ASP A 193
HIS A   8
HIS A  10
HIS A 139
 ZN  A 502 (-2.5A)
ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
 0.94A 5ncdA-5zb8A:
undetectable
5ncdD-5zb8A:
undetectable		 5ncdA-5zb8A:
undetectable
5ncdD-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 ASP A 193
HIS A  10
HIS A 195
HIS A 139
 ZN  A 502 (-2.5A)
ZN  A 502 (-3.3A)
None
ZN  A 501 (-3.3A)
 0.76A 5ncdA-5zb8A:
undetectable
5ncdD-5zb8A:
undetectable		 5ncdA-5zb8A:
undetectable
5ncdD-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 ASP A 193
HIS A  10
HIS A 195
HIS A 139
 ZN  A 502 (-2.5A)
ZN  A 502 (-3.3A)
None
ZN  A 501 (-3.3A)
 0.76A 5ncdB-5zb8A:
2.1
5ncdC-5zb8A:
2.4		 5ncdB-5zb8A:
undetectable
5ncdC-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 ASP A 193
HIS A   8
HIS A  10
HIS A 139
 ZN  A 502 (-2.5A)
ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
 1.01A 5nekB-5zb8A:
2.2		 5nekB-5zb8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 ASP A 193
HIS A  10
HIS A 195
HIS A 139
 ZN  A 502 (-2.5A)
ZN  A 502 (-3.3A)
None
ZN  A 501 (-3.3A)
 0.89A 5nekB-5zb8A:
2.2		 5nekB-5zb8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 8 ASP A 193
HIS A  10
HIS A 195
HIS A 139
 ZN  A 502 (-2.5A)
ZN  A 502 (-3.3A)
None
ZN  A 501 (-3.3A)
 0.89A 5nekD-5zb8A:
undetectable		 5nekD-5zb8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 ASP A 193
HIS A  10
HIS A 195
HIS A 139
 ZN  A 502 (-2.5A)
ZN  A 502 (-3.3A)
None
ZN  A 501 (-3.3A)
 0.74A 5nelA-5zb8A:
undetectable
5nelD-5zb8A:
undetectable		 5nelA-5zb8A:
undetectable
5nelD-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 HIS A  10
ASN A 116
VAL A  77
LEU A  86
 ZN  A 502 (-3.3A)
None
None
None
 1.36A 5xdhA-5zb8A:
undetectable
5xdhC-5zb8A:
undetectable		 5xdhA-5zb8A:
24.18
5xdhC-5zb8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 5 HIS A  10
ASN A 116
VAL A  77
LEU A  86
 ZN  A 502 (-3.3A)
None
None
None
 1.45A 5xdhB-5zb8A:
undetectable		 5xdhB-5zb8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 6 HIS A  10
ASN A 116
VAL A  77
LEU A  86
 ZN  A 502 (-3.3A)
None
None
None
 1.24A 5xdhA-5zb8A:
undetectable
5xdhC-5zb8A:
undetectable		 5xdhA-5zb8A:
24.18
5xdhC-5zb8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		4 / 5 HIS A  10
ASN A 116
VAL A  77
LEU A  86
 ZN  A 502 (-3.3A)
None
None
None
 1.44A 5xdhD-5zb8A:
undetectable		 5xdhD-5zb8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 12 GLY A  41
GLY A 113
LEU A   7
ASN A 191
PHE A  71
 None
 1.15A 5yn6A-5zb8A:
undetectable		 5yn6A-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5zb8 PFUENDOQ
(Pyrococcus
furiosus) 		5 / 12 LYS A 292
ALA A 177
ARG A 240
ASP A 173
LEU A 168
 None
 1.25A 6ie8A-5zb8A:
undetectable		 6ie8A-5zb8A:
undetectable