SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zbb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 5zbb -
(-) 		5 / 12 ILE A  72
ILE A  75
LEU A  12
VAL A  15
LEU A  16
 None
 0.97A 1df7A-5zbbA:
undetectable		 1df7A-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 5zbb -
(-) 		4 / 6 LEU A 111
LEU A  99
PRO A  17
VAL A  20
 IOD  A 608 ( 4.4A)
None
None
None
 1.20A 2dqyC-5zbbA:
undetectable		 2dqyC-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5zbb -
(-) 		5 / 9 ARG A 468
GLY A 467
LEU A  12
ASN A 469
ILE A 114
 None
 1.19A 3wdmA-5zbbA:
undetectable		 3wdmA-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5zbb -
(-) 		5 / 12 GLU A 273
PHE A 266
ASP A 271
SER A 292
GLN A 298
 None
 1.50A 4djeB-5zbbA:
undetectable		 4djeB-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5zbb -
(-) 		4 / 7 VAL A 452
TRP A 448
ILE A 427
HIS A 415
 None
 1.03A 4xo7B-5zbbA:
undetectable		 4xo7B-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5zbb -
(-) 		4 / 7 GLN A 307
ALA A 139
LEU A 164
TRP A 168
 None
None
None
IOD  A 601 (-4.6A)
 1.08A 5nwvA-5zbbA:
undetectable		 5nwvA-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 5zbb -
(-) 		5 / 12 PHE A 406
LEU A  12
ALA A  57
ILE A  27
ALA A 416
 None
 1.21A 5vc0A-5zbbA:
undetectable		 5vc0A-5zbbA:
undetectable