SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 TRP A 276
HIS A 306
MET A 310
 None
 0.85A 1l5qB-5zbhA:
undetectable		 1l5qB-5zbhA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 LEU A 279
ALA A  46
GLY A  48
TYR A  47
PHE A 302
 9AF  A1201 ( 3.9A)
None
None
None
9AF  A1201 (-3.6A)
 1.43A 1l5rA-5zbhA:
undetectable		 1l5rA-5zbhA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 4 VAL A 315
ALA A 271
LEU A 131
PHE A 272
 None
 1.26A 1q97B-5zbhA:
1.5		 1q97B-5zbhA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Homo
sapiens;
Escherichia
virus
T4) 		6 / 12 ILE A 124
ASP A  86
PHE A 272
ILE A 227
LEU A 224
ILE A 128
 9AF  A1201 (-4.2A)
None
None
None
None
None
 1.50A 1rx7A-5zbhA:
undetectable		 1rx7A-5zbhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 6 ALA A1062
TYR A1017
ILE A1026
LEU A1012
 None
 1.03A 1xvaA-5zbhA:
undetectable
1xvaB-5zbhA:
undetectable		 1xvaA-5zbhA:
undetectable
1xvaB-5zbhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 SER A  85
SER A 127
SER A  83
ASN A 316
 None
 1.05A 2i91A-5zbhA:
undetectable		 2i91A-5zbhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 SER A  85
SER A 127
SER A  83
ASN A 316
 None
 1.05A 2i91B-5zbhA:
undetectable		 2i91B-5zbhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 PHE A 327
SER A  83
LEU A  59
 None
 0.75A 2w1bA-5zbhA:
undetectable		 2w1bA-5zbhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 THR A  97
HIS A 306
LEU A 279
ASN A 283
 None
None
9AF  A1201 ( 3.9A)
9AF  A1201 (-3.7A)
 1.11A 4pfjA-5zbhA:
undetectable		 4pfjA-5zbhA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A1014
LEU A1012
THR A1058
ARG A 241
PRO A 145
 None
 1.23A 5nd3B-5zbhA:
undetectable		 5nd3B-5zbhA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 6 ASN A  73
THR A  75
ASN A  76
ARG A 138
 None
 0.92A 5uigA-5zbhA:
25.5		 5uigA-5zbhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ILE A  65
ASN A 324
ASN A  76
LEU A  61
LEU A  82
 None
 1.37A 6chgC-5zbhA:
undetectable		 6chgC-5zbhA:
undetectable