SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zbi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 10 PRO A 249
ILE A  93
TYR A  59
PRO A 242
GLY A 253
 None
 1.43A 13gsA-5zbiA:
undetectable		 13gsA-5zbiA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 9 PRO A 249
ILE A  93
TYR A  59
PRO A 242
GLY A 253
 None
 1.43A 13gsB-5zbiA:
undetectable		 13gsB-5zbiA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 10 LEU A 133
ALA A 142
VAL A 150
GLY A 145
PHE A 132
 None
 1.24A 1d4sA-5zbiA:
undetectable		 1d4sA-5zbiA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 11 ILE A  53
ILE A 213
PHE A 132
LEU A 189
ILE A 161
 None
 1.12A 1dg5A-5zbiA:
undetectable		 1dg5A-5zbiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 10 ILE A 106
ASP A  67
GLY A 257
TYR A 162
ALA A  71
 None
 1.47A 1ju6C-5zbiA:
undetectable		 1ju6C-5zbiA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 11 ILE A 106
ASP A  67
GLY A 257
TYR A 162
ALA A  71
 None
 1.46A 1ju6D-5zbiA:
undetectable		 1ju6D-5zbiA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 12 ILE A  85
GLY A  78
VAL A  80
ALA A 317
TYR A  72
 None
 1.40A 1nbhD-5zbiA:
undetectable		 1nbhD-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 10 SER A 227
ALA A 211
PHE A 214
LEU A 180
LEU A 185
 None
 1.06A 2bxqA-5zbiA:
undetectable		 2bxqA-5zbiA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 12 PHE A 203
LEU A 180
ILE A 213
PHE A 214
GLY A  55
 None
 1.12A 2lbdA-5zbiA:
undetectable		 2lbdA-5zbiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		4 / 7 TYR A 162
THR A 164
VAL A 262
VAL A 114
 None
 1.01A 2qbnA-5zbiA:
undetectable		 2qbnA-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		4 / 8 HIS A 166
ASN A  61
TYR A 168
ARG A 375
 None
 0.94A 2v57A-5zbiA:
undetectable		 2v57A-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		4 / 8 HIS A 166
ASN A  61
TYR A 168
ARG A 375
 None
 0.94A 2v57C-5zbiA:
undetectable		 2v57C-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 11 ILE A 161
LEU A 180
LEU A 133
ILE A 136
ILE A 186
 None
 0.99A 2w9sA-5zbiA:
undetectable		 2w9sA-5zbiA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 11 ILE A 161
LEU A 180
LEU A 133
ILE A 136
ILE A 186
 None
 0.99A 2w9sB-5zbiA:
undetectable		 2w9sB-5zbiA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 12 LEU A 259
ASP A 258
GLY A 257
TYR A 240
HIS A  70
 None
 1.29A 3hgiA-5zbiA:
undetectable		 3hgiA-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 11 SER A 459
GLY A 456
ALA A 458
LEU A 442
ILE A 445
 None
 1.03A 4dt8A-5zbiA:
undetectable		 4dt8A-5zbiA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 10 SER A 459
GLY A 456
ALA A 458
ILE A 385
ILE A 445
 None
 0.97A 4dt8B-5zbiA:
undetectable		 4dt8B-5zbiA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 10 VAL A 378
ILE A 382
TYR A 181
LEU A 417
LEU A 442
 None
 1.29A 4jq4B-5zbiA:
undetectable		 4jq4B-5zbiA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		4 / 5 PHE A 441
THR A 423
PHE A 424
ILE A 445
 None
 1.17A 4jx1E-5zbiA:
undetectable		 4jx1E-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 10 LEU A 172
GLY A 173
ASN A  61
SER A  56
ALA A 229
 None
 1.12A 4xj7C-5zbiA:
undetectable
4xj7D-5zbiA:
3.1		 4xj7C-5zbiA:
16.22
4xj7D-5zbiA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 12 GLY A 167
GLY A 235
SER A 236
GLY A 170
SER A 212
 None
 0.90A 5gwxA-5zbiA:
2.4		 5gwxA-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 12 GLY A 167
GLY A 235
SER A 236
GLY A 170
SER A 212
 None
 0.95A 5hikA-5zbiA:
undetectable		 5hikA-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 10 ILE A 106
ASP A  67
GLY A 257
TYR A 162
ALA A  71
 None
 1.35A 5x66D-5zbiA:
undetectable		 5x66D-5zbiA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		3 / 3 LYS A 329
PRO A 332
LYS A 288
 None
 1.28A 5y9yA-5zbiA:
undetectable		 5y9yA-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		5 / 12 ILE A  86
ILE A 159
VAL A  68
ALA A  71
LEU A  75
 None
 1.06A 6ajiA-5zbiA:
undetectable		 6ajiA-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5zbi PEPTIDE ASPARAGINYL
LIGASE
(Viola
canadensis) 		4 / 7 THR A 263
ARG A  63
HIS A 345
ASP A 258
 None
 1.28A 6mn4E-5zbiA:
undetectable		 6mn4E-5zbiA:
undetectable