SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 TRP A 276
HIS A 306
MET A 310
 None
 1.04A 1l5qB-5zbqA:
undetectable		 1l5qB-5zbqA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 LYS A1042
LEU A1038
ALA A1041
SER A1035
 None
 1.27A 1tyrA-5zbqA:
undetectable		 1tyrA-5zbqA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 LEU A 323
ILE A 261
ASN A  73
GLU A  70
 None
 0.92A 2opxA-5zbqA:
undetectable		 2opxA-5zbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ILE A 261
GLU A 137
TYR A 320
ARG A 138
ALA A 135
 None
 1.31A 2vppA-5zbqA:
undetectable		 2vppA-5zbqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 GLY A 109
ALA A 111
MET A 112
LEU A 115
 None
 0.88A 2wekB-5zbqA:
undetectable		 2wekB-5zbqA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 PHE A 302
ALA A 309
THR A 313
LEU A  94
VAL A  89
 9AO  A1301 (-4.0A)
None
None
None
None
 1.43A 2wuzA-5zbqA:
undetectable		 2wuzA-5zbqA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 PHE A 302
ALA A 309
THR A 313
LEU A  94
VAL A  89
 9AO  A1301 (-4.0A)
None
None
None
None
 1.41A 2wuzB-5zbqA:
undetectable		 2wuzB-5zbqA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 THR A1033
TYR A1024
ILE A1016
SER A1035
 None
 1.04A 2xytE-5zbqA:
undetectable		 2xytE-5zbqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 THR A1033
TYR A1024
ILE A1016
SER A1035
 None
 1.00A 2xytH-5zbqA:
undetectable		 2xytH-5zbqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 THR A1033
TYR A1024
ILE A1016
SER A1035
 None
 1.01A 2xytI-5zbqA:
undetectable		 2xytI-5zbqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 6 ASN A  73
THR A  75
ASN A  76
ARG A 138
 None
 1.09A 5uigA-5zbqA:
23.5		 5uigA-5zbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 8 ILE A 227
ALA A 273
VAL A 274
ASP A  86
 None
 1.00A 6hu9a-5zbqA:
2.6
6hu9e-5zbqA:
0.8		 6hu9a-5zbqA:
undetectable
6hu9e-5zbqA:
undetectable