SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 12 VAL A  46
VAL A  33
LEU A 155
LEU A  37
LEU A 147
 None
 1.12A 1mx1E-5zbyA:
undetectable		 1mx1E-5zbyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 12 ILE A  87
ILE A 154
LEU A 155
VAL A  46
ILE A  16
 None
 0.84A 1oipA-5zbyA:
undetectable		 1oipA-5zbyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 12 ILE A  16
LEU A 155
ASN A 157
VAL A  71
GLU A   5
 None
 1.20A 2vn0A-5zbyA:
undetectable		 2vn0A-5zbyA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		4 / 7 PRO A  67
ILE A 120
LEU A  91
THR A 116
 None
 0.92A 3p50A-5zbyA:
undetectable		 3p50A-5zbyA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		4 / 7 PRO A  67
ILE A 120
LEU A  91
THR A 116
 None
 0.92A 3p50B-5zbyA:
undetectable		 3p50B-5zbyA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		4 / 7 PRO A  67
ILE A 120
LEU A  91
THR A 116
 None
 0.93A 3p50C-5zbyA:
undetectable		 3p50C-5zbyA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		4 / 7 PRO A  67
ILE A 120
LEU A  91
THR A 116
 None
 0.93A 3p50D-5zbyA:
undetectable		 3p50D-5zbyA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		4 / 7 PRO A  67
ILE A 120
LEU A  91
THR A 116
 None
 0.93A 3p50E-5zbyA:
undetectable		 3p50E-5zbyA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		4 / 6 GLY A  80
GLY A  79
GLU A  84
ILE A  86
 None
 0.87A 4fglD-5zbyA:
4.1		 4fglD-5zbyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 9 VAL A  33
ALA A  34
GLY A 124
PHE A  29
GLY A  18
 None
 1.06A 4mm5A-5zbyA:
undetectable		 4mm5A-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 12 VAL A  33
ALA A  34
PHE A  85
PHE A  29
GLY A  18
 None
 1.25A 4mm6A-5zbyA:
undetectable		 4mm6A-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 9 VAL A  33
ALA A  34
GLY A 124
PHE A  29
GLY A  18
 None
 1.01A 4mmbA-5zbyA:
undetectable		 4mmbA-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 10 VAL A  33
ALA A  34
GLY A 124
PHE A  29
GLY A  18
 None
 1.03A 4mmdA-5zbyA:
undetectable		 4mmdA-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 9 VAL A  33
ALA A  34
GLY A 124
PHE A  29
GLY A  18
 None
 1.09A 4mmeB-5zbyA:
undetectable		 4mmeB-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 9 VAL A  33
ALA A  34
GLY A 124
PHE A  29
GLY A  18
 None
 0.96A 4mmfB-5zbyA:
undetectable		 4mmfB-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		3 / 3 GLU A 134
ILE A  82
ALA A  28
 None
 0.66A 4wnwB-5zbyA:
undetectable		 4wnwB-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		5 / 12 ILE A  87
ILE A 154
LEU A 155
VAL A  46
ILE A  16
 None
 0.77A 5mugA-5zbyA:
undetectable		 5mugA-5zbyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		4 / 6 LYS A  61
VAL A  46
ILE A  16
LYS A  38
 None
 1.49A 5q1sA-5zbyA:
3.9		 5q1sA-5zbyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5zby HYDROGENASE
MATURATION PROTEASE
HYCI
(Thermococcus
kodakarensis) 		4 / 6 CYH A 125
ILE A  76
GLN A 126
ILE A 140
 None
 1.21A 6cbdA-5zbyA:
3.3		 6cbdA-5zbyA:
undetectable