SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		4 / 5 LEU C 254
LEU C 234
CYH C 244
THR C 243
 None
 1.43A 2oaxD-5zcsC:
undetectable		 2oaxD-5zcsC:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		4 / 7 ILE C  88
GLN C 148
ARG C 110
ASP C 106
 None
 1.00A 2qqcB-5zcsC:
undetectable
2qqcC-5zcsC:
undetectable		 2qqcB-5zcsC:
23.00
2qqcC-5zcsC:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		4 / 6 ILE C 173
MET C 185
ILE C 144
HIS C 153
 None
 1.03A 3eteA-5zcsC:
undetectable
3eteE-5zcsC:
undetectable		 3eteA-5zcsC:
12.09
3eteE-5zcsC:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		4 / 5 ILE C 173
MET C 185
ILE C 144
HIS C 153
 None
 1.02A 3eteB-5zcsC:
undetectable
3eteC-5zcsC:
undetectable		 3eteB-5zcsC:
12.09
3eteC-5zcsC:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		4 / 7 MET C 185
ILE C 144
HIS C 153
ILE C 173
 None
 1.03A 3eteD-5zcsC:
undetectable
3eteF-5zcsC:
undetectable		 3eteD-5zcsC:
12.09
3eteF-5zcsC:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		4 / 8 GLN C  63
GLN C  41
HIS C  40
HIS C  64
 None
 1.05A 5km8A-5zcsC:
undetectable
5km8B-5zcsC:
undetectable		 5km8A-5zcsC:
15.44
5km8B-5zcsC:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		4 / 6 LEU C 199
SER C 183
ASP C 181
HIS C 177
 None
 1.22A 5om3A-5zcsC:
undetectable
5om3B-5zcsC:
undetectable		 5om3A-5zcsC:
18.39
5om3B-5zcsC:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		5 / 12 ILE C 304
CYH C 244
CYH C 238
LEU C 258
GLY C 302
 None
 1.45A 6bp4B-5zcsC:
undetectable		 6bp4B-5zcsC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens) 		5 / 12 ALA C  29
THR C 287
PHE C 320
VAL C  13
VAL C 324
 None
 1.41A 6hu9N-5zcsC:
undetectable		 6hu9N-5zcsC:
undetectable