SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CD2_A_FOLA307_0 (DIHYDROFOLATE REDUCTASE)	5zcy	PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG (Pyrococcus horikoshii)	5 / 12	ILE A 96 ILE A 43 THR A 38 LEU A 57 ILE A 82	None	1.03A	2cd2A-5zcyA: undetectable	2cd2A-5zcyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9S_E_TOPE1160_1 (DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003)	5zcy	PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG (Pyrococcus horikoshii)	4 / 8	ILE A 24 LEU A 57 ILE A 43 PHE A 91	None	0.67A	2w9sE-5zcyA: undetectable	2w9sE-5zcyA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2X_A_TMQA202_1 (DIHYDROFOLATE REDUCTASE)	5zcy	PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG (Pyrococcus horikoshii)	5 / 12	ILE A 96 ARG A 71 LEU A 74 LEU A 57 ILE A 82	None	1.02A	4m2xA-5zcyA: undetectable	4m2xA-5zcyA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2X_E_TMQE202_1 (DIHYDROFOLATE REDUCTASE)	5zcy	PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG (Pyrococcus horikoshii)	5 / 12	ILE A 96 ARG A 71 LEU A 74 LEU A 57 ILE A 82	None	1.00A	4m2xE-5zcyA: undetectable	4m2xE-5zcyA: 19.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2CD2_A_FOLA307_0","DIHYDROFOLATE REDUCTASE","5zcy","PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG","Pyrococcus horikoshii",5,"ILE A  96;ILE A  43;THR A  38;LEU A  57;ILE A  82","None","1.03A","2cd2A-5zcyA:undetectable","2cd2A-5zcyA:undetectable"],["2W9S_E_TOPE1160_1","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","5zcy","PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG","Pyrococcus horikoshii",4,"ILE A  24;LEU A  57;ILE A  43;PHE A  91","None","0.67A","2w9sE-5zcyA:undetectable","2w9sE-5zcyA:18.75"],["4M2X_A_TMQA202_1","DIHYDROFOLATE REDUCTASE","5zcy","PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG","Pyrococcus horikoshii",5,"ILE A  96;ARG A  71;LEU A  74;LEU A  57;ILE A  82","None","1.02A","4m2xA-5zcyA:undetectable","4m2xA-5zcyA:19.50"],["4M2X_E_TMQE202_1","DIHYDROFOLATE REDUCTASE","5zcy","PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG","Pyrococcus horikoshii",5,"ILE A  96;ARG A  71;LEU A  74;LEU A  57;ILE A  82","None","1.00A","4m2xE-5zcyA:undetectable","4m2xE-5zcyA:19.50"]]