SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zdm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5zdm -
(-) 		3 / 3 VAL A 132
VAL A 108
TRP A 106
 None
 0.69A 1av2A-5zdmA:
undetectable
1av2B-5zdmA:
undetectable		 1av2A-5zdmA:
undetectable
1av2B-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5zdm -
(-) 		3 / 3 VAL A 108
TRP A 106
VAL A 132
 None
 0.70A 2izqC-5zdmA:
undetectable
2izqD-5zdmA:
undetectable		 2izqC-5zdmA:
undetectable
2izqD-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5zdm -
(-) 		4 / 5 TYR A  32
GLU A 111
ASP A 125
ASP A 143
 GOL  A 303 (-4.5A)
None
CA  A 301 ( 2.8A)
CA  A 302 (-3.4A)
 1.41A 2yqzA-5zdmA:
undetectable		 2yqzA-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5zdm -
(-) 		4 / 5 TYR A  32
GLU A 111
ASP A 125
ASP A 143
 GOL  A 303 (-4.5A)
None
CA  A 301 ( 2.8A)
CA  A 302 (-3.4A)
 1.42A 2yqzB-5zdmA:
undetectable		 2yqzB-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5zdm -
(-) 		4 / 8 VAL A  92
VAL A 132
TRP A 106
TRP A 181
 None
 1.20A 3nlqA-5zdmA:
undetectable
3nlqB-5zdmA:
undetectable		 3nlqA-5zdmA:
undetectable
3nlqB-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5zdm -
(-) 		4 / 8 ARG A  20
ARG A 115
GLU A  23
HIS A 126
 GOL  A 303 (-3.7A)
None
None
None
 1.47A 3zmdA-5zdmA:
undetectable
3zmdB-5zdmA:
undetectable		 3zmdA-5zdmA:
undetectable
3zmdB-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5zdm -
(-) 		4 / 8 ASP A 125
ARG A 140
ASN A 109
GLU A 127
 CA  A 301 ( 2.8A)
GOL  A 305 (-3.9A)
CA  A 301 (-2.7A)
CA  A 302 (-3.3A)
 1.00A 4gkhF-5zdmA:
undetectable		 4gkhF-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5zdm -
(-) 		4 / 6 ARG A  20
ASP A  22
HIS A  66
ILE A  30
 GOL  A 303 (-3.7A)
GOL  A 303 (-3.1A)
GOL  A 303 (-3.7A)
GOL  A 303 (-4.5A)
 1.20A 5a06A-5zdmA:
undetectable		 5a06A-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5zdm -
(-) 		3 / 3 GLU A 167
HIS A 126
VAL A 110
 None
 0.92A 5trqB-5zdmA:
undetectable		 5trqB-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 5zdm -
(-) 		3 / 3 PHE A 147
ASP A 143
LYS A 146
 None
CA  A 302 (-3.4A)
CA  A 302 ( 4.5A)
 0.82A 6awtD-5zdmA:
undetectable		 6awtD-5zdmA:
undetectable