SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ze3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		3 / 3 HIS A 628
HIS A 630
HIS A 626
 ZN  A 803 (-3.2A)
ZN  A 803 (-3.1A)
ZN  A 803 (-3.1A)
 0.71A 1rjoA-5ze3A:
undetectable		 1rjoA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		3 / 3 HIS A 628
HIS A 630
HIS A 626
 ZN  A 803 (-3.2A)
ZN  A 803 (-3.1A)
ZN  A 803 (-3.1A)
 0.68A 1rkyA-5ze3A:
undetectable		 1rkyA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		5 / 12 SER A 583
GLY A 651
ALA A 649
LEU A 640
THR A 636
 None
 0.89A 2nyuB-5ze3A:
undetectable		 2nyuB-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		5 / 12 GLY A 750
GLY A 345
GLU A 346
ILE A 403
VAL A 341
 None
 1.04A 2oxtA-5ze3A:
undetectable		 2oxtA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		5 / 12 GLY A 330
GLU A 340
GLY A 384
ILE A 385
LEU A 381
 None
 0.83A 2x1lB-5ze3A:
undetectable		 2x1lB-5ze3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 8 HIS A 496
GLY A 497
ASN A 438
TRP A 495
 None
 1.18A 3ccfA-5ze3A:
undetectable		 3ccfA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		5 / 9 HIS A 652
ASP A 699
ILE A 700
VAL A 703
VAL A 648
 None
 1.50A 3fi0J-5ze3A:
undetectable		 3fi0J-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 7 GLU A 472
VAL A 476
VAL A 463
ALA A 539
 None
 1.03A 3kp6B-5ze3A:
undetectable		 3kp6B-5ze3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		3 / 3 LEU A 357
TRP A 355
GLY A 421
 None
 0.62A 3l35A-5ze3A:
undetectable
3l35H-5ze3A:
undetectable		 3l35A-5ze3A:
undetectable
3l35H-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		3 / 3 LEU A 357
TRP A 355
GLY A 421
 None
 0.64A 3l35B-5ze3A:
undetectable
3l35K-5ze3A:
undetectable		 3l35B-5ze3A:
undetectable
3l35K-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 6 VAL A 326
VAL A 422
PHE A 369
GLU A 366
 None
 1.43A 3n61A-5ze3A:
undetectable
3n61B-5ze3A:
undetectable		 3n61A-5ze3A:
12.32
3n61B-5ze3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 6 HIS A 626
HIS A 628
HIS A 630
ASP A 687
 ZN  A 803 (-3.1A)
ZN  A 803 (-3.2A)
ZN  A 803 (-3.1A)
None
 1.08A 3nvcA-5ze3A:
undetectable		 3nvcA-5ze3A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 6 HIS A 630
HIS A 626
HIS A 628
ASP A 687
 ZN  A 803 (-3.1A)
ZN  A 803 (-3.1A)
ZN  A 803 (-3.2A)
None
 1.23A 3nvcA-5ze3A:
undetectable		 3nvcA-5ze3A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		3 / 3 TYR A 744
ASP A 707
ASP A 737
 None
 0.54A 4a6eA-5ze3A:
undetectable		 4a6eA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		5 / 12 ASN A 553
ILE A 388
ASP A 419
GLY A 384
ASN A 606
 None
 1.33A 4djfA-5ze3A:
undetectable		 4djfA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 5 ARG A 441
TRP A 495
HIS A 496
GLY A 439
 None
 1.08A 4e7cC-5ze3A:
undetectable		 4e7cC-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		3 / 3 ASP A 707
ARG A 733
ASP A 737
 None
 0.72A 4fp9C-5ze3A:
undetectable		 4fp9C-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		3 / 3 ASP A 707
ARG A 733
ASP A 737
 None
 0.71A 4fp9F-5ze3A:
undetectable		 4fp9F-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 6 SER A 609
GLY A 421
ARG A 423
GLY A 337
 None
 0.92A 5cdnC-5ze3A:
undetectable
5cdnD-5ze3A:
undetectable		 5cdnC-5ze3A:
12.21
5cdnD-5ze3A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 6 SER A 609
GLY A 421
ARG A 423
GLY A 337
 None
 0.95A 5cdnT-5ze3A:
undetectable
5cdnU-5ze3A:
undetectable		 5cdnT-5ze3A:
12.21
5cdnU-5ze3A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 8 ASP A 692
HIS A 623
HIS A 691
GLU A 659
 None
 1.24A 6mn4A-5ze3A:
undetectable		 6mn4A-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 8 ASP A 692
HIS A 623
HIS A 691
GLU A 659
 None
 1.25A 6mn4B-5ze3A:
undetectable		 6mn4B-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens) 		4 / 8 ASP A 692
HIS A 623
HIS A 691
GLU A 659
 None
 1.09A 6mn4D-5ze3A:
undetectable		 6mn4D-5ze3A:
undetectable