SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ze8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 11 ASP A  82
TYR A  76
GLY A  73
MET A  88
ALA A  85
 None
 1.49A 1e3vB-5ze8A:
undetectable		 1e3vB-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 8 ASP A 269
GLY A 265
GLY A 266
GLN A  55
 None
 0.80A 1ekjA-5ze8A:
undetectable
1ekjB-5ze8A:
undetectable		 1ekjA-5ze8A:
undetectable
1ekjB-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 6 GLN A  55
ASP A 269
VAL A 263
GLY A 265
 None
 1.23A 1ekjC-5ze8A:
undetectable
1ekjD-5ze8A:
undetectable		 1ekjC-5ze8A:
undetectable
1ekjD-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 6 ASP A 269
VAL A 263
GLY A 265
GLN A  55
 None
 1.22A 1ekjC-5ze8A:
undetectable
1ekjD-5ze8A:
undetectable		 1ekjC-5ze8A:
undetectable
1ekjD-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 7 ASP A 269
GLY A 265
GLY A 266
GLN A  55
 None
 0.79A 1ekjE-5ze8A:
undetectable
1ekjF-5ze8A:
undetectable		 1ekjE-5ze8A:
undetectable
1ekjF-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 8 ASP A 269
GLY A 265
GLY A 266
GLN A  55
 None
 0.83A 1ekjG-5ze8A:
undetectable
1ekjH-5ze8A:
undetectable		 1ekjG-5ze8A:
undetectable
1ekjH-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 10 ALA A 353
MET A 312
LEU A 378
ARG A 384
ILE A 428
 None
HEM  A 505 ( 3.7A)
None
None
None
 1.45A 1qkuA-5ze8A:
undetectable		 1qkuA-5ze8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 10 ALA A 353
MET A 312
LEU A 378
ARG A 384
ILE A 428
 None
HEM  A 505 ( 3.7A)
None
None
None
 1.46A 1qkuB-5ze8A:
undetectable		 1qkuB-5ze8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 10 ALA A 353
MET A 312
LEU A 378
ARG A 384
ILE A 428
 None
HEM  A 505 ( 3.7A)
None
None
None
 1.46A 1qkuC-5ze8A:
undetectable		 1qkuC-5ze8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 9 LEU A 407
ARG A 319
PHE A 318
LEU A 418
LEU A  74
 None
HEM  A 502 ( 2.8A)
HEM  A 502 ( 4.9A)
None
None
 1.30A 2bxeA-5ze8A:
undetectable		 2bxeA-5ze8A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 6 ASN A 106
HIS A  38
ASN A 126
THR A 132
 None
 1.17A 2hkkA-5ze8A:
undetectable		 2hkkA-5ze8A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 12 ALA A 107
GLN A 111
PRO A  97
GLY A  87
LEU A 115
 None
 1.32A 2nv4B-5ze8A:
undetectable		 2nv4B-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 HIS A 342
PRO A 343
TYR A 403
PRO A 425
 None
 1.25A 2ombA-5ze8A:
4.5
2ombB-5ze8A:
4.0		 2ombA-5ze8A:
undetectable
2ombB-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 7 HIS A 342
PRO A 343
TYR A 403
PRO A 425
 None
 1.28A 2ombC-5ze8A:
4.3
2ombD-5ze8A:
4.2		 2ombC-5ze8A:
undetectable
2ombD-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 4 LEU A 418
PRO A 419
LEU A 422
ARG A 319
 None
None
None
HEM  A 502 ( 2.8A)
 1.26A 2qd2A-5ze8A:
undetectable		 2qd2A-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 4 LEU A 418
PRO A 419
LEU A 422
ARG A 319
 None
None
None
HEM  A 502 ( 2.8A)
 1.37A 3hcoA-5ze8A:
undetectable		 3hcoA-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 LEU A 422
ARG A 319
LEU A 418
PRO A  70
 None
HEM  A 502 ( 2.8A)
None
None
 1.32A 3onnA-5ze8A:
undetectable		 3onnA-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.85A 4k8cA-5ze8A:
undetectable		 4k8cA-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.85A 4kahA-5ze8A:
undetectable		 4kahA-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.84A 4kahB-5ze8A:
undetectable		 4kahB-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.85A 4kanA-5ze8A:
undetectable		 4kanA-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.85A 4kanB-5ze8A:
undetectable		 4kanB-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.83A 4kbeA-5ze8A:
undetectable		 4kbeA-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.82A 4kbeB-5ze8A:
undetectable		 4kbeB-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.88A 4lbgA-5ze8A:
undetectable		 4lbgA-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		3 / 3 SER A  42
TYR A  53
PRO A 119
 HEM  A 503 ( 4.7A)
None
None
 0.87A 4lbgB-5ze8A:
undetectable		 4lbgB-5ze8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 10 ASP A  82
HIS A  72
VAL A  80
LEU A 100
ALA A 104
 None
HEM  A 502 (-4.1A)
None
None
None
 1.04A 4yhaB-5ze8A:
undetectable		 4yhaB-5ze8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 10 VAL A  80
LEU A 115
LEU A 100
PHE A  96
THR A 113
 None
 1.35A 4zmeB-5ze8A:
undetectable		 4zmeB-5ze8A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.16A 5hm8A-5ze8A:
undetectable		 5hm8A-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.16A 5hm8B-5ze8A:
undetectable		 5hm8B-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.16A 5hm8C-5ze8A:
undetectable		 5hm8C-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.16A 5hm8D-5ze8A:
undetectable		 5hm8D-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.16A 5hm8E-5ze8A:
undetectable		 5hm8E-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.16A 5hm8F-5ze8A:
undetectable		 5hm8F-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.19A 5hm8G-5ze8A:
undetectable		 5hm8G-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 5 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.16A 5hm8H-5ze8A:
undetectable		 5hm8H-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		4 / 6 LEU A 115
CYH A  99
HIS A 103
LEU A 100
 None
HEM  A 502 (-1.9A)
HEM  A 502 (-3.3A)
None
 1.06A 5hpuC-5ze8A:
undetectable
5hpuD-5ze8A:
undetectable		 5hpuC-5ze8A:
undetectable
5hpuD-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 11 VAL A  40
SER A  41
GLU A 123
PRO A 208
LEU A 210
 None
None
None
None
HEM  A 501 (-4.6A)
 1.19A 5jh7B-5ze8A:
undetectable		 5jh7B-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5ze8 CYTOCHROME C552
(Thermochromatium
tepidum) 		5 / 11 VAL A  40
SER A  41
GLU A 123
PRO A 208
LEU A 210
 None
None
None
None
HEM  A 501 (-4.6A)
 1.22A 5jh7D-5ze8A:
undetectable		 5jh7D-5ze8A:
undetectable